口腔医学研究

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (8): 776-780.DOI: 10.13701/j.cnki.kqyxyj.2020.08.017

• 口腔黏膜病学研究 • 上一篇    下一篇

伴VitB12缺乏的萎缩性舌炎患者相关实验室参数变化分析

赵毛毛1, 段宁1, 王翔1, 刘婷1, 李兵1, 周憧憧1, 陈兵2, 王文梅1*   

  1. 1. 南京大学医学院附属口腔医院·南京市口腔医院口腔黏膜病科 江苏 南京 210008;
    2. 南京大学医学院附属鼓楼医院血液科 江苏 南京 210008
  • 收稿日期:2020-05-11 出版日期:2020-08-28 发布日期:2020-08-18
  • 通讯作者: *王文梅,E-mail:wangwenmei0102@163.com
  • 作者简介:赵毛毛(1992~ ),女,山西朔州人,硕士在读,主要从事口腔黏膜病变基础研究和临床工作。
  • 基金资助:
    国家自然科学基金(编号:81870767);江苏省临床医学科技专项(编号:BL2014018);江苏省科教强卫青年医学人才项目(编号:QNRC2016118)

Analysis of Changes in Laboratory Parameters in Patients with Atrophic Glossitis Associated with VitB12 Deficiency

ZHAO Maomao1, DUAN Ning1, WANG Xiang1, LIU Ting1, LI Bing1, ZHOU Chongchong1, CHEN Bing2, WANG Wenmei1*   

  1. 1. Department of Oral Membrane Disease, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing210008, China;
    2. Department of Hematology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
  • Received:2020-05-11 Online:2020-08-28 Published:2020-08-18

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摘要： 目的: 本研究旨在分析伴VitB12缺乏的萎缩性舌炎患者相关实验室参数变化,探讨伴VitB12缺乏萎缩性舌炎患者临床分型与相关实验室参数变化的关联性。方法: 纳入2016年3月~2019年12月于我院口腔黏膜病科就诊的63例伴VitB12缺乏的萎缩性舌炎,根据舌黏膜萎缩程度将其分为完全型和部分型,观察患者VitB12、FOL及红细胞相关参数(RBC、Hb、MCV、MCH、MCHC、RDW)的变化,并对其相关性做进一步分析。结果: 本研究63例患者中,完全型患者与部分型比较,VitB12、RBC、Hb水平下降明显,MCV、MCH水平上升明显;完全型患者伴有大细胞性贫血或红细胞巨幼变的概率高于部分型,差异显著;完全型患者与部分型比较,FOL、MCHC、RDW的参数水平无显著性差异。整体分析,本研究患者的VitB12水平与RBC、Hb水平为正相关,VitB12水平与MCV、MCH水平变化为负相关。结论: 伴VitB12缺乏的萎缩性舌炎患者其舌黏膜萎缩的程度与VitB12缺乏程度密切相关外,亦与大细胞性贫血或红细胞巨幼变密切相关,萎缩性舌炎是VitB12缺乏及大细胞性贫血类全身性疾病的重要体征之一。

关键词: 萎缩性舌炎, VitB12, 叶酸, 红细胞相关参数, 大细胞性贫血

Abstract: Objective: To analyze the changes of laboratory parameters in patients with atrophic glossitis associated with VitB12 deficiency and to explore its correlation between clinical types and changes of laboratory parameters. Methods: 63 cases of atrophic glossitis with VitB12 deficiency were included from the Department of Oral Membrane Disease in our hospital from March 2016 to December 2019. According to the degree of atrophic tongue mucosa, they were divided into complete type and partial type. Changes in the levels of VitB12, folic acid, and erythrocyte parameters (red blood cells, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width) were observed and their correlation was further analyzed. Results: In the atrophic glossitis patients with VitB12 deficiency, the levels of VitB12, red blood cells, and hemoglobin decreased significantly, the levels of mean corpuscular volume and mean corpuscular hemoglobin increased significantly. The incidence of macrocytic anemia or macrocytosis in patients with complete type was higher than that of partial type (P<0.05). There was no significant difference in the parameter levels of folic acid, mean corpuscular hemoglobin concentration, and red blood cell distribution width between complete type and partial type. Overall analysis showed that the VitB12 level was positively correlated with red blood cells and hemoglobin levels in 63 patients with VitB12 deficiency glossitis, while the VitB12 level was negatively correlated with mean corpuscular volume and mean corpuscular hemoglobin concentration levels. Conclusion: The degree of tongue mucosa atrophy in patients with atrophic glossitis associated with VitB12 deficiency is not only closely related to the degree of VitB12 deficiency, but also closely related to macrocytic anemia or macrocytosis. Atrophic glossitis is one of the important signs of systemic diseases such as VitB12 deficiency and macrocytic anemia.

Key words: atrophic glossitis, Vitamin B12, folic acid, erythrocyte related parameter, macrocytic anemia