口腔医学研究

口腔医学研究 ›› 2024, Vol. 40 ›› Issue (11): 1028-1031.DOI: 10.13701/j.cnki.kqyxyj.2024.11.017

• 研究生病例精粹———口腔黏膜病系列(11) • 上一篇    

司库奇尤单抗诱发口腔念珠菌病1例

李志军1,2, 卢锐1,2*   

  1. 1.口颌系统重建与再生全国重点实验室,口腔生物医学教育部重点实验室,口腔医学湖北省重点实验室,武汉大学口腔医(学)院 湖北 武汉 430079;
    2.武汉大学口腔医院口腔黏膜科 湖北 武汉 430079
  • 收稿日期:2024-10-28 出版日期:2024-11-28 发布日期:2024-11-27
  • 通讯作者: *卢锐,E-mail:lurui@whu.edu.cn
  • 作者简介:李志军(2001~ ),男,江西抚州人,硕士在读,研究方向:口腔黏膜病学。

Oral Candidiasis Induced by Secukinumab: A Case Report

LI Zhijun, LU Rui*   

  1. 1. State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China;
    2. Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  • Received:2024-10-28 Online:2024-11-28 Published:2024-11-27

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摘要： 口腔念珠菌病是一种常见的口腔黏膜真菌感染性疾病,多见于各类因素导致机体防御能力降低的人群。由于广谱抗生素、糖皮质激素的广泛应用,以及近年来一些新型免疫调节制剂和生物制剂的不断问世,由药物导致的医源性口腔念珠菌病逐年增多。在口腔念珠菌病的诊疗过程中,控制诱发因素是取得良好疗效的关键,因此明确该病的诱发因素对于规范诊疗具有重要意义。本文报道1例因治疗银屑病使用司库奇尤单抗诱发口腔念珠菌病的诊疗过程,以期为临床认识口腔念珠菌病新的诱发因素及制定相应诊疗策略提供参考。

关键词: 口腔念珠菌病, 司库奇尤单抗, 真菌D-葡聚糖荧光检测

Abstract: Oral candidiasis is a common fungal infectious disease of the oral mucosa, which is more often seen in people with reduced defenses due to various factors. With the wide application of broad-spectrum antibiotics, glucocorticoids, and the development of novel immunomodulatory agents and biologics, iatrogenic oral candidiasis caused by medicine usage is increasing recently. In the diagnosis and treatment of oral candidiasis, controlling the predisposing factors is the key to achieving good therapeutic effect, so it is important to clarify the predisposing factors of the disease for the standardized diagnosis and treatment. Here we reports a case of oral candidiasis induced by the use of secukinumab for the treatment of psoriasis, aiming to provide reference for clinical understanding of new causes of oral candidiasis and formulating corresponding treatment strategies.

Key words: oral candidiasis, secukinumab, fungal D-glucan fluorescence detection