单细胞转录组测序在头颈部鳞状细胞癌研究中的应用进展

doi:10.13701/j.cnki.kqyxyj.2024.12.002

口腔医学研究 ›› 2024, Vol. 40 ›› Issue (12): 1042-1048.DOI: 10.13701/j.cnki.kqyxyj.2024.12.002

单细胞转录组测序在头颈部鳞状细胞癌研究中的应用进展

刘海岩^1,2, 马坚^1,2,3*

1.宁夏医科大学口腔医学院宁夏银川 750004;
2.宁夏颅颌面畸形研究重点实验室宁夏银川 750004;
3.宁夏医科大学总医院口腔医院宁夏银川 750004

收稿日期:2024-01-15 出版日期:2024-12-28 发布日期:2024-12-23
通讯作者: *马坚,E-mail:majianhs310@163.com
作者简介:刘海岩(1997~ ),男,银川人,硕士在读,研究方向:口腔颌面外科学。
基金资助:
宁夏自然科学基金项目(编号:2022AAC03473)

Application of Single-cell Transcriptome Sequencing in Study of Head and Neck Squamous Cell Carcinoma

LIU Haiyan^1,2, MA Jian^1,2,3*

1. Stomatology College of Ningxia Medical University, Yinchuan 750004, China;
2. Ningxia Key Laboratory of Craniomaxillofacial Malformation Research, Yinchuan 750004, China;
3. Hospital of Stomatology, the General Hospital of Ningxia Medical University, Yinchuan 750004, China

Received:2024-01-15 Online:2024-12-28 Published:2024-12-23

摘要/Abstract

摘要： 头颈部鳞状细胞癌是最常见的头颈部恶性肿瘤,该疾病异质性显著,病因至今仍未明确。单细胞转录组测序可以在单个细胞水平上,通过无偏、高通量和高分辨率的转录组测序获得相关数据并进行信息分析,已成为了解头颈部鳞状细胞癌发生的分子机制,制定预防和治疗新策略的有力工具。本文概述了单细胞转录组测序在肿瘤微环境的表征、肿瘤侵袭和转移、人乳头状瘤病毒(human papilloma virus,HPV)与非HPV感染头颈部鳞状细胞癌和免疫治疗方面的研究成果及应用进展,旨在为头颈部鳞状细胞癌的研究与诊疗提供新思路。

关键词: 单细胞转录组测序, 头颈部鳞状细胞癌, 肿瘤微环境, 人乳头状瘤病毒, 肿瘤免疫

Abstract: Head and neck squamous cell carcinoma (HNSCC) is the most prevalent cancer of the head and neck which exhibits significant heterogeneity, and its etiology remains incompletely understood. Single-cell transcriptome sequencing enables unbiased, high-throughput and high-resolution transcriptome sequencing to obtain relevant data and perform information analysis at the single-cell level, which has become a powerful tool to understand the molecular mechanisms of the development of HNSCC and to develop new strategies for prevention and treatment. This review summarized the important study and latest achievements of single-cell transcriptome sequencing in the characterization of tumor microenvironment, tumor invasion and metastasis, human papilloma virus (HPV⁺) and HPV^- infection of HNSCC, and immunotherapy, aiming to provide new ideas for the research, diagnosis, and treatment of HNSCC.

Key words: single-cell RNA sequencing, head and neck squamous cell carcinoma, tumor micro-environment, human papilloma virus, cancer immunotherapy

刘海岩, 马坚. 单细胞转录组测序在头颈部鳞状细胞癌研究中的应用进展[J]. 口腔医学研究, 2024, 40(12): 1042-1048.

LIU Haiyan, MA Jian. Application of Single-cell Transcriptome Sequencing in Study of Head and Neck Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2024, 40(12): 1042-1048.

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单细胞转录组测序在头颈部鳞状细胞癌研究中的应用进展

Application of Single-cell Transcriptome Sequencing in Study of Head and Neck Squamous Cell Carcinoma

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