口腔医学研究

口腔医学研究 ›› 2026, Vol. 42 ›› Issue (9): 810-812.DOI: 10.13701/j.cnki.kqyxyj.2026.09.014

• 病例报告 • 上一篇    下一篇

腭部微分泌腺癌1例

王佳俐, 陈虎, 张祖斌, 王洪涛*   

  1. 三峡大学第一临床医学院·宜昌市中心人民医院口腔科 湖北 宜昌 443000
  • 收稿日期:2025-10-09 出版日期:2026-09-28 发布日期:2026-09-22
  • 通讯作者: * 王洪涛,E-mail:82210052@qq.com
  • 作者简介:王佳俐(1996~ ),女,荆州人,硕士,主治医师,研究方向:口腔颌面外科-肿瘤。

Microsecretory Adenocarcinoma in Palate: A Case Report

WANG Jiali, CHEN Hu, ZHANG Zubin, WANG Hongtao*   

  1. The First College of Clinical Medical Science, Three Gorges University·Department of Stomatology, Yichang Central People's Hospital, Yichang 443000, China
  • Received:2025-10-09 Online:2026-09-28 Published:2026-09-22

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摘要： 本文回顾性分析1例因“腭部无痛性肿物5个月”入院患者的诊疗过程。该病例术前穿刺疑为黏液表皮样癌,术中冰冻病理未能排除黏液表皮样癌或多形性腺瘤,术后病理及会诊意见不一,先后考虑多形性腺瘤或低级别涎腺癌(腺样囊性癌待排),最终通过FISH检测提示SS18基因断裂,确诊为唾液腺微分泌腺癌(microsecretory adenocarcinoma,MSA)。旨在系统性认识其临床病理学特征,实现MSA的精准诊断与鉴别。

关键词: 唾液腺肿瘤, 微分泌腺癌, 误诊

Abstract: This paper retrospectively analyzes the diagnosis and treatment of a patient admitted for a 5-month history of painless mass in the palate. Preoperative fine-needle aspiration raised suspicion of mucoepidermoid carcinoma. Intraoperative frozen section pathology failed to definitively exclude either mucoepidermoid carcinoma or pleomorphic adenoma. Postoperative histopathological examination and expert consultations yielded divergent interpretations, initially considering pleomorphic adenoma or low-grade salivary gland carcinoma with adenoid cystic carcinoma as a differential. Ultimately, FISH detection of SS18 gene break-apart confirmed the diagnosis of microsecretory adenocarcinoma (MSA) of the salivary gland. A systematic understanding of its clinicopathological characteristics is therefore imperative for accurate diagnosis and differential diagnosis.

Key words: salivary gland, microsecretory adenocarcinoma, misdiagnosis