口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (9): 907-911.DOI: 10.13701/j.cnki.kqyxyj.2016.09.004

• 基础研究论著 • 上一篇    下一篇

PHMG根管封闭剂的制备及性能测定

贾美娥1,乃正刚1,林君2,解斯羽1,张学琛1,任君3,何祥一1*   

  1. 1. 兰州大学口腔医学研究所 甘肃 兰州 730000;
    2. 青岛市中心医院口腔科 山东 青岛 266000;
    3. 兰州大学生命科学学院 甘肃 兰州 730000
  • 收稿日期:2016-02-22 出版日期:2016-09-26 发布日期:2016-09-26
  • 通讯作者: 何祥一,E-mail:Hexy@lzu.edu.cn
  • 作者简介:贾美娥(1992~ ),女,河北衡水人,学士,主要从事口腔内科材料研究。
  • 基金资助:
    君政基金(编号:JZSH20150005)

Performance of Root Canal Sealing Agent Modified by Polyhexamethylene Guanidine

JIA Mei-e1, NAI Zheng-gang1, LIN Jun2, XIE Si-yu1, ZHANG Xue-chen1, REN Jun3, HE Xiang-yi1*   

  1. 1. School of Stomatology, Lanzhou University, Lanzhou 730000, China;
    2. Qingdao Center Hospital, Qingdao 266000, China;
    3. School of Life Science, Lanzhou University, Lanzhou 730000, China
  • Received:2016-02-22 Online:2016-09-26 Published:2016-09-26

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摘要： 目的:制备并筛选出符合ISO 6876:2001标准的聚六亚甲基单胍(PHMG)改性根管封闭剂,测定其物理性能和抑菌性能,以开发具有较强抑菌性能的新型根管封闭剂。方法:以氧化锌丁香油糊剂(ZOE)为对照,按照ISO 6876:2001规定的方法,测定不同PHMG浓度的根管封闭剂的物理性能;采用琼脂扩散法,测定其对粪肠球菌、白色念珠菌、大肠杆菌、金黄色葡萄球菌的抑菌性能;并进行统计学分析。结果:11组不同材料的流动性、固化时间、薄膜厚度和溶解率均符合ISO 6876:2001标准;固化后尺寸变化中以浓度为0.8%~2.0%的材料符合ISO 6876:2001标准。PHMG根管封闭剂的抑菌性显著高于氧化锌丁香油糊剂的抑菌性(P＜0.05)。结论:成功制备出符合新型根管封闭剂要求的PHMG根管封闭剂;PHMG浓度在0.8%~1.4%之间的根管封闭剂性能最佳。

关键词: PHMG, 根管封闭剂, 物理性能, 抑菌性能

Abstract: Objective: To prepare and screen the PHMG modified root canal sealing agent which was in accordance with ISO 6876:2001 standard and study its physical properties and antimicrobial activity. Methods: The physical properties of the root canal sealing agents with different PHMG concentrations were measured according to ISO 6876:6876 rules using ZOE paste as control. The ager diffusion test was employed to evaluate the antimicrobial effects of the materials against the following microbes: E. faecalis, C. albicans, E. Coli and S. aureus in vitro. Results: The liquidity, setting time, film thickness and solubility of eleven samples met the ISO 6876:2001 standard. However, only in the group which the concentration of PHMG was 0.8% to 2.0%, the dimensional change met the ISO 6876:2001 standard. The antimicrobial activity of the PHMG modified root canal sealing agent was significantly higher than that of the control group (P＜0.05). Conclusion: Modified PHMG was prepared and met the ISO standard. The root canal sealing agents with the PHMG concentrations between 0.8% and 1.2% showed the best performance.

Key words: PHMG, Root canal sealing agent, Physical properties, Antimicrobial activity

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