三联抗生素糊剂在年轻恒牙牙髓再生中的应用

doi:10.13701/j.cnki.kqyxyj.2019.07.003

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (7): 629-631.DOI: 10.13701/j.cnki.kqyxyj.2019.07.003

三联抗生素糊剂在年轻恒牙牙髓再生中的应用

徐静晨^1,2,3,4, 黄睿洁^1,2,3*

1. 口腔疾病研究国家重点实验室四川成都 610041;
2. 国家口腔疾病临床医学研究中心四川成都 610041;
3. 四川大学华西口腔医院儿童口腔科四川成都 610041;
4. 四川大学华西口腔医学院口腔正畸科四川成都 610041

收稿日期:2018-05-22 出版日期:2019-07-25 发布日期:2019-07-24
通讯作者: 黄睿洁,E-mail:hwangrj@163.com
作者简介:徐静晨(1995~ ),女,河北省保定人,硕士在读,研究方向:口腔正畸学
基金资助:
四川大学青年教师科研启动基金(编号:2016SCU11042)

Application of Triple Antibiotic Paste in Pulp Regeneration of Young Permanent Teeth

XU Jingchen^1,2,3,4, HUANG Ruijie^1,2,3*

1. State Key Laboratory of Oral Disease Research, Chengdu 610041, China;
2. National Center for Clinical Medicine of Stomatology Diseases, Chengdu 610041, China;
3. Department of Pediatric Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
4. Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Received:2018-05-22 Online:2019-07-25 Published:2019-07-24

摘要/Abstract

摘要： 近年来,牙髓再生作为年轻恒牙牙髓根尖病变的有效治疗方法获得了学界的肯定,而控制根管感染作为其成功的关键也受到广泛关注。三联抗生素糊剂(triple antibiotic paste,TAP)由甲硝唑、环丙沙星和米诺环素组成,适宜浓度下具有理想的抗菌效果和时间,细胞毒性小,有效促进牙髓组织的保存与再生及牙体硬组织的形成,但也存在牙齿变色、细菌耐药等问题。本文对近年来TAP在年轻恒牙牙髓再生治疗中的应用及其特点作一综述

关键词: 三联抗生素糊剂, 牙髓再生, 控制感染, 根管消毒

Abstract: Pulp regeneration has been admitted as an effective treatment of pulpitis and periapical inflammation of young permanent teeth in recent years. The root canal system and periapical region infection control, the key of successful pulp regeneration, becomes a public concern. Triple antibiotic paste (TAP) contains metronidazole, ciprofloxacin, and minocycline. With the appropriate working concentration and time, it could achieve an ideal bacterial inhibitory effect, sterilize the root canal system, minimize cell toxicity, facilitate pulp tissue conversation and regeneration, and promote the root and related tooth hard tissues development. However, there are also some disadvantages of TAP such as tooth discoloration, drug resistance, and etc. This review would summarize the application and characteristics of TAP in the pulp regeneration of young permanent teeth

Key words: triple antibiotic paste, pulp regeneration, infection control, root canal system disinfection

徐静晨, 黄睿洁. 三联抗生素糊剂在年轻恒牙牙髓再生中的应用[J]. 口腔医学研究, 2019, 35(7): 629-631.

XU Jingchen, HUANG Ruijie. Application of Triple Antibiotic Paste in Pulp Regeneration of Young Permanent Teeth[J]. Journal of Oral Science Research, 2019, 35(7): 629-631.

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三联抗生素糊剂在年轻恒牙牙髓再生中的应用

Application of Triple Antibiotic Paste in Pulp Regeneration of Young Permanent Teeth

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