口腔医学研究

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (1): 67-70.DOI: 10.13701/j.cnki.kqyxyj.2021.01.015

• 口腔麻醉学研究 • 上一篇    下一篇

纳布啡联合舒芬太尼对颌面部骨折患者术后镇痛及炎症因子水平的影响

李美胜1,2, 高鸿1,3*   

  1. 1.贵州医科大学麻醉学院 贵州 贵阳 550000;
    2.口腔疾病研究国家重点实验室/国家口腔疾病临床医学研究中心/四川大学华西口腔医院麻醉科 四川 成都 610041;
    3.贵州医科大学第三附属医院 贵州 都匀 558000
  • 收稿日期:2020-03-25 出版日期:2021-01-28 发布日期:2021-01-22
  • 通讯作者: *高鸿,E-mail:2169617@qq.com
  • 作者简介:李美胜(1981~ ),男,河南杞县人,硕士在读,主治医师,研究方向:口腔颌面外科麻醉、口腔舒适化治疗、围术期镇痛与康复。

Effects of Nalbuphine and Sufentanil on Postoperative Analgesia and Inflammatory Factors in Patients with Maxillofacial Fracture

LI Meisheng1,3, GAO Hong1,2*   

  1. 1. School of Anesthesiology, Guizhou Medical University, Guiyang 550004, China;
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
    3. Third Affiliated Hospital of Guizhou Medical University, Duyun 558000, China
  • Received:2020-03-25 Online:2021-01-28 Published:2021-01-22

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摘要： 目的: 观察纳布啡联合舒芬太尼对颌面部骨折患者术后镇痛效果以及炎症因子水平的变化。方法: 将2019年8月~2019年11月期间在我院接受术后静脉自控镇痛的80例颌面部骨折患者作为实验对象,随机分为对照组及研究组(每组40例),其中对照组给与舒芬太尼,研究组给与纳布啡联合舒芬太尼,并对两组患者术后不同时间点(2、4、8、12、24、48 h)疼痛视觉模拟评分、Ramsay镇静评分(RSS评分)、术后48 h自控镇痛总按压次数及有效按压次数、患者的满意度以及外周血中C反应蛋白和降钙素原、生活恢复质量量表评分等进行对比分析。结果: 用药2 h后,两组VAS评分、RSS评分在用药2 h后的无意义,而在用药4、8、12、24、48 h后,研究组明显好于对照组;研究组术后总按压次数、有效按压次数均低于对照组;研究组满意度好于对照组;两组术前C反应蛋白、降钙素原之间的差异无统计学意义(P>0.05),术后研究组的C反应蛋白、降钙素原明显均低于对照组;研究组生活质量评分好于对照组。结论: 纳布啡结合舒芬太尼可明显增强术后镇痛效果,可降低机体炎症因子水平,同时提高患者满意度及生活水平,值得临床应用。

关键词: 纳布啡, 舒芬太尼, 颌面部骨折, C反应蛋白, 降钙素原

Abstract: Objective: To observe the postoperative analgesic effect of nbuphine combined with sufentanil on patients with maxillofacial fractures and the changes of inflammatory factors. Methods: Eighty patients with postoperative intravenous controlled analgesia in our hospital from August 2019 to November 2019 with maxillofacial fractures were randomly divided into control group and study group (40 patients in each group). At different time points after surgery, visual analog pain score, Ramsay sedation score, after 48h self-control analgesia in patients with total number of press number and press, satisfaction, c-reactive protein and calcitonin original in the peripheral blood, and the quality of life score were analyzed. Results: VAS scores and RSS scores of the two groups were insignificant after 2h of administration, while the study group was significantly better than the control group after 4 h, 8 h, 12 h, 24 h, and 48 h of administration. The total number of postoperative compressions and effective compressions in the study group were lower than those in the control group. The satisfaction of the study group was better than that of the control group. There was no statistically significant difference between the two groups in c-reactive protein and procalcitonin before operation (P>0.05). The quality of life score of the study group was better than that of the control group. Conclusion: Nabuphine combined with sufentanil can significantly enhance the postoperative analgesic effect, reduce the level of inflammatory factors in the body, and improve patient satisfaction and living standard, which is worthy of clinical application.

Key words: nalbuphine, sufentanil, maxillofacial fracture, C-reactive protein, procalcitonin