干燥综合征患者唾液流率与口干症状的一致性分析

doi:10.13701/j.cnki.kqyxyj.2023.08.016

口腔医学研究 ›› 2023, Vol. 39 ›› Issue (8): 751-754.DOI: 10.13701/j.cnki.kqyxyj.2023.08.016

干燥综合征患者唾液流率与口干症状的一致性分析

卫明慧¹, 汪苑苑¹, 汪玉红¹, 王新文^1*, 杜望磊^2*

1.口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院口腔黏膜病科陕西西安 710032;
2.空军军医大学第一附属医院临床免疫科陕西西安 710032

收稿日期:2023-02-06 发布日期:2023-08-17
通讯作者: *王新文,E-mail:landw211@163.com;杜望磊,E-mail:271202569@qq.com
作者简介:卫明慧(1989~ ),女,山西运城人,硕士,主治医师,研究方向:口腔黏膜病学。
基金资助:
空军军医大学第三附属医院新技术新业务(编号:LX-2020-403)

Consistency of Salivary Flow Rate and Xerostomia in Patients with Sjögren's Syndrome

WEI Minghui¹, WANG Yuanyuan¹, WANG Yuhong¹, WANG Xinwen^1*, DU Wanglei^2*

1. State Key Laboratory of Oral &Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Clinical Research Center for Oral Diseases, Department of Oral medicine,School of Stomatology,the Fourth Military Medical University, Xi'an 710032, China;
2. Department of Clinical Immunology, First Affiliated Hospital, the Fourth Military Medical University, Xi'an 710032, China

Received:2023-02-06 Published:2023-08-17

摘要/Abstract

摘要： 目的: 分析干燥综合征(Sjögren's syndrome,SS)患者口干症状与静息唾液流率下降的一致性,并探讨影响静息唾液流率的相关因素。方法: 采集151例确诊SS患者的临床资料,包括口干症状、静息唾液流率、血液学指标及临床病史等,应用Kappa一致性检验和Spearman相关性检验进行统计学分析。结果: 干燥综合征患者中唾液流率下降与口干症有极低的一致性,进一步分析发现,静息唾液流率下降与SS病程、ANA抗体滴度、IgM水平及自身免疫性肝病呈正相关关系。结论: SS患者唾液流率下降与口干症状缺乏一致表现,静息唾液流率虽然对SS有一定的预测及监控价值,但受到多种因素影响可能出现波动,了解其影响因素并实施定向干预,有助于SS患者的口腔健康管理。

关键词: 干燥综合征, 静息唾液流率, IgM, 口干, 自身免疫性肝病, SSA, SSB

Abstract: Objective: To assess the consistency of salivary flow rate and xerostomia, and explore the risk factors for reduced salivary flow rate in patients with Sjögren's syndrome (SS). Methods: The clinical data of 151 patients with SS were collected, including a sensation of oral dryness (xerostomia), unstimulated salivary flow rate (USFR), hematological indexes, and medical history. The Kappa consistency test and Spearman's correlation coefficient were used to analyze the data. Results: There was a very low consistency between the reduced USFR and xerostomia in SS patients. The reduced USFR was positively correlated with the course of SS, ANA antibody, IgM, and the comorbidity of autoimmune liver disease. Conclusion: The consistency of USFR and xerostomia in SS patients was poor. Although USFR has a certain predictive and monitoring value for SS, it may be influenced by multiple factors. Understanding the risk factors influencing USFR and implementing targeted intervention would be helpful for oral health management of SS patients.

Key words: Sjögren's syndrome, unstimulated salivary flow rate, IgM, xerostomia, autoimmune liver disease, SSA, SSB

卫明慧, 汪苑苑, 汪玉红, 王新文, 杜望磊. 干燥综合征患者唾液流率与口干症状的一致性分析[J]. 口腔医学研究, 2023, 39(8): 751-754.

WEI Minghui, WANG Yuanyuan, WANG Yuhong, WANG Xinwen, DU Wanglei. Consistency of Salivary Flow Rate and Xerostomia in Patients with Sjögren's Syndrome[J]. Journal of Oral Science Research, 2023, 39(8): 751-754.

参考文献

[1] 中华医学会风湿病学会. 干燥综合征诊断及治疗诊治指南[J]. 中华风湿病学杂志,2010,14(11):766-768.
[2] Pedersen AML, Sørensen CE, Proctor GB, et al. Salivary secretion in health and disease [J]. J Oral Rehabil, 2018, 45(9):730-746.
[3] Cartee DL, Maker S, Dalonges D, et al. Sjögren's syndrome: Oral manifestations and treatment, a dental perspective [J]. Int J Dent Hyg, 2015, 89(6):365-371.
[4] 俞光岩,宿骞,张艳,等. 唾液腺疾病与全身系统性疾病的相关性[J]. 北京大学学报(医学版),2023,55(1):1-7.
[5] 张文,厉小梅,徐东,等. 原发性干燥综合征诊疗规范[J]. 中华内科杂志,2020,59(4):269-273.
[6] Bolstad AI, Skarstein K. Epidemiology of Sjögren's syndrome from an oral perspective [J]. Curr Oral Health Rep, 2016, 3(4):328-336.
[7] Ramos-Casals M, Brito-Zerón P, Bombardieri S, et al. EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies [J]. Ann Rheum Dis, 2020, 79(1):3-18.
[8] 胡朝军,周仁芳,张蜀澜. 抗核抗体检测的临床应用专家共识[J]. 中华检验医学杂志,2018,41(4):275-280.
[9] Lacombe V, Lacout C, Lozac'h P, et al. Unstimulated whole saliva flow for diagnosis of primary Sjögren's syndrome: time to revisit the threshold [J]. Arthritis Res Ther, 2020, 22(1):38-40.
[10] Maliska M. The role of Epstein Barr virus infection in primary Sjögren's syndrome [J]. Curr Opin Rheumatol, 2019, 31(5):475-483.
[11] Houen G, Trier NH. Epstein-Barr virus and systemic autoimmune diseases [J]. Front Immunol, 2021, 11:587380.
[12] Nakamura H, Kawakami A. What is the evidence for Sjögren's syndrome being triggered by viral infection? Subplot: infections that cause clinical features of Sjögren's syndrome [J]. Curr Opin Rheumatol, 2016, 28(4):390-397.
[13] Liu Z, Chu A. Sjögren's syndrome and viral infections [J]. Rheumatol Ther, 2021, 8(3):1051-1059.
[14] de Oliveira NC, de Oliveira TC, Klamas VC, et al. Salivary flow, amylase, and total protein in hospitalized patients with HIV infection/AIDS complications [J]. Afr Health Sci, 2020, 20(2):597-604.
[15] Chowdhury F, Grigoriadou S, Bombardieri M. Severity of COVID-19 infection in primary Sjögren's syndrome and the emerging evidence of COVID-19-induced xerostomia [J]. Clin Exp Rheumatol, 2021, 133(6):215-222.

干燥综合征患者唾液流率与口干症状的一致性分析

Consistency of Salivary Flow Rate and Xerostomia in Patients with Sjögren's Syndrome

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

[1]	黄擎, 阮敏. 下颌下腺腺体功能保存的研究进展[J]. 口腔医学研究, 2020, 36(10): 905-907.
[2]	朱红华, 公柏娟, 宋子琦, 鞠昊, 冯婧, 李志民, 孙宏晨. 电离辐射对大鼠颌下腺钙离子激活型钾通道的影响[J]. 口腔医学研究, 2017, 33(8): 828-831.
[3]	孙东亮,叶涛,卢倩,于世宾. 吸毒人群口腔疾病发病特点回顾[J]. 口腔医学研究, 2017, 33(12): 1338-1341.
[4]	俞洁,章功杰,陈松军,郑珉,李丽. 糖尿病患者唾液流率与口干相关性研究[J]. 口腔医学研究, 2016, 32(2): 177-180.