近生理条件下在釉质表面原位再生类釉质氟磷灰石的研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (7): 724-727.

近生理条件下在釉质表面原位再生类釉质氟磷灰石的研究

郗红¹,张恺²,董志恒⁴,王丹丹³,布文奂³,孙宏晨³,黄洋^1*

1. 吉林大学口腔医院儿童口腔科吉林长春 130021;
2. 吉林大学超分子和材料国家重点实验室;
3. 吉林大学口腔医院病理科;
4. 滨州医学院附属医院口腔科

收稿日期:2014-11-11 出版日期:2015-07-28 发布日期:2015-07-28
通讯作者: 黄洋,电话:0431-88796038
作者简介:郗红(1987~ ),女,山东潍坊人,硕士,主要从事儿童口腔病学的研究工作。

In Situ Regeneration of Enamel-like Fluoridated Hydroxyapatite on Enamel Surface under Near Physiological Conditions

XI Hong, ZHANG Kai, DONG Zhi-heng, et al

Department of Pediatric Dentistry, School of Stomatology, Jilin University, Changchun 130021

Received:2014-11-11 Online:2015-07-28 Published:2015-07-28

摘要/Abstract

摘要： 目的:近生理条件下在釉质表面原位合成晶体排列有序的类釉质样氟磷灰石结构。方法:使用HEDTA、CaCl₂、NaH₂PO₄·2H₂O和NaF作为原料,配成所需矿化液与基板在37 ℃水浴条件下作用一段时间可获得所需结构。用XRD、FTIR、SEM、EDS、MTT实验、抑菌环实验等评价合成结构的理化生方面性能。结果:合成结构主要成分是氟磷灰石,呈典型六棱柱结构,并且排列有序且紧密。结论:在近生理条件下合成的结构能够初步模拟釉质的形貌、组成,并有一定抑菌功能。

关键词: 釉质龋, 氟磷灰石, 仿生材料, 形态可控合成

Abstract: Objective: To achieve in situ regeneration of enamel-like fluoridated hydroxyapatite on enamel surface under near physiological conditions. Methods: FA enamel-like structure was produced on the enamel surface of human teeth by a simple chemical method using HEDTA,CaCl₂,NaH₂PO₄·2H₂O,and NaF as the reactants under the condition of 37℃ water bath for a period of time. The physicochemical and biological properties of the enamel-like structure were studied by XRD,FTIR,SEM,XPS,MTT assay and bacterial inhibition ring test. Results: The compacted well-aligned FA crystals were produced,which could grow directly on the enamel surface. Conclusion: The synthetic structure under the condition of near physiological conditions can preliminarily mimic the shape and structure of enamel, and has the biocompatibility and certain antibacterial function.

Key words: Enamel caries, Fluorapatite, Biomimetic materials, Form controllable synthesis

中图分类号:

R780.1

郗红,张恺,董志恒,王丹丹,布文奂,孙宏晨,黄洋. 近生理条件下在釉质表面原位再生类釉质氟磷灰石的研究[J]. 口腔医学研究, 2015, 31(7): 724-727.

XI Hong, ZHANG Kai, DONG Zhi-heng, et al. In Situ Regeneration of Enamel-like Fluoridated Hydroxyapatite on Enamel Surface under Near Physiological Conditions[J]. Journal of Oral Science Research, 2015, 31(7): 724-727.

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