甲状旁腺素在口腔治疗应用中的研究进展

doi:10.13701/j.cnki.kqyxyj.2020.08.004

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (8): 719-722.DOI: 10.13701/j.cnki.kqyxyj.2020.08.004

甲状旁腺素在口腔治疗应用中的研究进展

张耀元, 王林^*

南京医科大学口腔疾病研究江苏省重点实验室,南京医科大学附属口腔医院正畸科江苏南京 210029

收稿日期:2019-08-16 出版日期:2020-08-28 发布日期:2020-08-18
通讯作者: *王林,E-mail: lw603@njmu.edu.cn
作者简介:张耀元(1993~ ),女,吉林长春人,硕士,主要从事口腔正畸学研究工作。
基金资助:
江苏高校优势学科建设工程资助项目(编号:PAPD,2018-87);科教强卫(编号:ZDXKA2016026)

Research Progress of Parathyroid Hormone in Oral Therapy

ZHANG Yaoyuan, WANG Lin^*

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University; Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China

Received:2019-08-16 Online:2020-08-28 Published:2020-08-18

摘要/Abstract

摘要： 甲状旁腺素(parathyroid hormone,PTH)是钙磷稳态重要的调节因子,对其靶器官骨的代谢具有双重调节作用,既能促进骨的形成,也能加速骨的吸收。PTH对骨代谢的双重影响主要取决于其给药剂量、给药方式及机体自身的PTH水平,间歇性低剂量PTH在口腔疾病治疗中发挥着积极作用。本文将对PTH调节颅颌面骨代谢的机制及其在口腔领域中的应用研究进行综述,为PTH在口腔治疗中的应用提供理论依据和参考。

关键词: 甲状旁腺素, 颅颌面骨代谢, 口腔治疗, 应用

Abstract: Parathyroid hormone (PTH) is an important regulator of calcium and phosphorus homeostasis. It has dual regulatory effects on bone metabolism, which can promote bone formation and can accelerate bone absorption. The dual effects of PTH on bone metabolism mainly depend on its dosage, mode of administration, and physical body's PTH level. Intermittent low-dose PTH plays an active role in the treatment of oral diseases. In the essay, the regulation mechanism of PTH on craniomaxillofacial bone and the analysis of PTH application in oral therapy are comprehensively summarized, which provides theory foundation and reference for PTH application on oral therapy.

Key words: parathyroid hormone, craniomaxillofacial bone metabolism, oral therapy, application

张耀元, 王林. 甲状旁腺素在口腔治疗应用中的研究进展[J]. 口腔医学研究, 2020, 36(8): 719-722.

ZHANG Yaoyuan, WANG Lin. Research Progress of Parathyroid Hormone in Oral Therapy[J]. Journal of Oral Science Research, 2020, 36(8): 719-722.

参考文献

[1] Luo Y, Li SY, Tian FM, et al. Effects of human parathyroid hormone 1-34 on bone loss and lumbar intervertebral disc degeneration in ovariectomized rats [J]. Int Orthop, 2018, 42(5): 1183-1190.
[2] Milstrey A, Wieskoetter B, Hinze D, et al. Dose-dependent effect of parathyroid hormone on fracture healing and bone formation in mice [J]. J Surg Res, 2017, 220: 327-335.
[3] Aggarwal P, Zavras A. Parathyroid hormone and its effects on dental tissues [J]. Oral Dis, 2012, 18(1): 48-54.
[4] Chan HL, McCauley LK. Parathyroid hormone applications in the craniofacial skeleton [J]. J Dent Res, 2013, 92(1): 18-25.
[5] Runyan CM, Gabrick KS. Biology of bone formation, fracture healing, and distraction osteogenesis [J]. J Craniofac Surg, 2017, 28(5): 1380-1389.
[6] 陈嵩,陈扬熙.颅面骨生长发育及正畸治疗中的3种骨调控机制及其概念[J].华西口腔医学杂志,2009,27(5): 577-581.
[7] Andreassen TT, Cacciafesta V. Intermittent parathyroid hormone treatment enhances guided bone regeneration in rat calvarial bone defects [J]. J Craniofac Surg, 2004, 15(3): 424-427.
[8] Ishizuya T, Yokose S, Hori M, et al. Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells [J]. J Clin Invest, 1997, 99(12): 2961-2970.
[9] Choi H, Magyar CE, Nervina JM, et al. Different duration of parathyroid hormone exposure distinctively regulates primary response genes Nurr1 and RANKL in osteoblasts [J]. PLoS One, 2018, 13(12): e0208514.
[10] Yi J, Mei L, Li X, et al. Effects of continuous and intermittent parathyroid hormone administration on midpalatal suture expansion in rats [J]. Arch Oral Biol, 2019, 99:161-168.
[11] Wang L, Tran AB, Nociti FH, et al. PTH and vitamin D repress DMP1 in cementoblasts [J]. J Dent Res, 2015, 94(10):1408-1416.
[12] Li Y, Hu Z, Zhou C, et al. Intermittent parathyroid hormone (PTH) promotes cementogenesis and alleviates the catabolic effects of mechanical strain in cementoblasts [J]. BMC Cell Biol, 2017, 18(1): 19.
[13] 王生瑜.甲状旁腺素(PTH)对正畸牙根吸收后修复影响的研究[D].泸州医学院,2011.
[14] Xu Y, Lv C, Zhang J, et al. Intermittent parathyroid hormone promotes cementogenesis in a PKA- and ERK1/2-dependent manner [J]. J Periodontol, 2019, 90(9):1002-1013.
[15] Soma S, Iwamoto M, Higuchi Y, et al. Effects of continuous infusion of PTH on experimental tooth movement in rats [J]. J Bone Miner Res, 1999, 14(4): 546-554.
[16] Soma S, Matsumoto S, Higuchi Y, et al. Local and chronic application of PTH accelerates tooth movement in rats [J]. J Dent Res, 2000, 79(9): 1717-1724.
[17] Lee HS, Heo HA, Park SH, et al. Influence of human parathyroid hormone during orthodontic tooth movement and relapse in the osteoporotic rat model: A preliminary study [J]. Orthod Craniofac Res, 2018, 21(3):125-131.
[18] Li Y, Chen XY, Tang ZL, et al. Differences in accelerated tooth movement promoted by recombinant human parathyroid hormone after mandibular ramus osteotomy [J]. Am J Orthod Dentofacial Orthop, 2019, 155(5): 670-680.
[19] 韩晶,金剑,姚志勇,等.PTH对大鼠髁突发育影响的实验研究[J].口腔医学研究,2009,25(6):709-712.
[20] Liu Q, Wan Q, Yang R, et al. Effects of intermittent versus continuous parathyroid hormone administration on condylar chondrocyte proliferation and differentiation [J]. Biochem Biophys Res Commun, 2012, 424(1): 182-188.
[21] Dutra EH, O'Brien MH, Chen PJ, et al. Intermittent parathyroid hormone [1-34] augments chondrogenesis of the mandibular condylar cartilage of the temporomandibular joint [J]. Cartilage, 2019:1947603519833146.
[22] Wan Q, Li ZB. Intra-articular injection of parathyroid hormone in the temporomandibular joint as a novel therapy for mandibular asymmetry [J]. Med Hypotheses, 2010, 74(4): 685-687.
[23] Kuroshima S, Kovacic BL, Kozloff KM, et al. Intra-oral PTH administration promotes tooth extraction socket healing [J]. J Dent Res, 2013, 92(6): 553-559.
[24] Kuroshima S, Mecano RB, Tanoue R, et al. Distinctive tooth-extraction socket healing: bisphosphonate versus parathyroid hormone therapy [J]. J Periodontol, 2014, 85(1): 24-33.
[25] Ali MN, Kobayashi T, Tanaka M, et al. Effects of intermittent parathyroid hormone treatment on new bone formation during distraction osteogenesis in the rat mandible [J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012, 114(1): e36-e42.
[26] Gallagher KK, Deshpande S, Tchanque-Fossuo CN, et al. Role of parathyroid hormone therapy in reversing radiation-induced nonunion and normalization of radiomorphometrics in a murine mandibular model of distraction osteogenesis [J]. Head Neck, 2013, 35(12): 1732-1737.
[27] Kang SY, Deshpande SS, Zheutlin AR, et al. Role of parathyroid hormone in regeneration of irradiated bone in a murine model of mandibular distraction osteogenesis [J]. Head Neck, 2017, 39(3): 464-470.
[28] Tang ZL, Bai S, Zhu PN, et al. An examination of differences in the new bone formation promoted by different doses of recombinant human parathyroid hormone during mandibular distraction osteogenesis [J]. Plast Reconstr Surg, 2016, 137(2): 347e-354e.
[29] Ye B, Li Y, Zhu S, et al. Effects of intermittent low-dose parathyroid hormone treatment on rapid mandibular distraction osteogenesis in rabbits [J]. J Oral Maxillofac Surg, 2017, 75(8): 1722-1731.
[30] 孙智慧,郑宇,王俐杰,等.局部应用重组人甲状旁腺激素(1-34)对即刻种植骨整合的作用[J].中国组织工程研究,2017,21(26):4210-4216.
[31] Park S, Heo HA, Kim KW, et al. Intermittent parathyroid hormone improves bone formation around titanium implants in osteoporotic rat maxillae [J]. Int J Oral Maxillofac Implants, 2017, 32(1): 204-209.
[32] 王烟岚,王萧萧,陈天宇,等.牙周膜干细胞与牙周膜细胞甲状旁腺激素受体表达的比较[J].中国组织工程研究,2015,19(10):1562-1569.
[33] Wolf M, Lossdorfer S, Marciniak J, et al. CD8⁺ T cells mediate the regenerative PTH effect in hPDL cells via Wnt10b signaling [J]. Innate Immun, 2016, 22(8): 674-681.
[34] Tokunaga K, Seto H, Ohba H, et al. Topical and intermittent application of parathyroid hormone recovers alveolar bone loss in rat experimental periodontitis [J]. J Periodontal Res, 2011, 46(6): 655-662.
[35] 庄颖,庞希瑶,蔡琴,等.rhPTH(1-34)间断刺激对人根尖牙乳头干细胞增殖及成牙成骨分化的影响[J].口腔生物医学,2018,9(3):125-128.
[36] Otawa M, Tanoue R, Kido H, et al. Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice [J]. J Endod, 2015, 41(5): 646-651.

甲状旁腺素在口腔治疗应用中的研究进展

Research Progress of Parathyroid Hormone in Oral Therapy

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 6

编辑推荐

Metrics

[1]	何孔炎, 陈艳, 缪颖, 缪海梅. 改良不翻瓣微创种植术的临床应用观察[J]. 口腔医学研究, 2018, 34(2): 181-185.
[2]	陈温霞, 林捷. 陶瓷还是复合树脂？CAD/CAM树脂基陶瓷材料的研究进展[J]. 口腔医学研究, 2018, 34(10): 1042-1044.
[3]	刘艳丽. 口腔种植修复中附着龈重建的回顾性分析[J]. 口腔医学研究, 2018, 34(10): 1102-1104.
[4]	刘洪，颜成东，蒋尚飞. 甲状旁腺素相关肽核定位序列和C-末端缺失对小鼠下颌骨发育的影响[J]. 口腔医学研究, 2017, 33(10): 1044-1047.
[5]	王丹丹, 秦珊, 吴再辉, 郭燕川. 三氧化矿物聚合物的研究现状[J]. 口腔医学研究, 2016, 32(7): 771-775.
[6]	潘小萌,黄谢山,余海,翦新春,石小田,刘德裕,陈尧卉,白真玉,韩静欣. 耳后肌筋膜骨膜瓣设计和血管网的应用解剖学研究[J]. 口腔医学研究, 2016, 32(11): 1168-1170.