器官芯片在口腔疾病研究中的应用

doi:10.13701/j.cnki.kqyxyj.2026.01.002

口腔医学研究 ›› 2026, Vol. 42 ›› Issue (1): 8-11.DOI: 10.13701/j.cnki.kqyxyj.2026.01.002

器官芯片在口腔疾病研究中的应用

刘张翘楚, 黄心智^*

上海交通大学医学院上海 201318

收稿日期:2025-02-12 出版日期:2026-01-28 发布日期:2026-01-23
通讯作者: *黄心智,E-mail:jyhuangxz@shsmu.edu.cn
作者简介:刘张翘楚(2004~ ),女,辽宁人,八年制口腔专业在读,研究方向:高糖状态下干细胞功能及组织缺损的组织工程修复。

Application of Organ-on-a-chip Technology in Oral Disease Research

LIU Zhangqiaochu, HUANG Xinzhi^*

Shanghai Jiao Tong University School of Medicine, Shanghai 201318, China

Received:2025-02-12 Online:2026-01-28 Published:2026-01-23

摘要/Abstract

摘要： 口腔具有复杂的生理特性和独特的解剖环境,传统的二维体外模型难以准确模拟。器官芯片是一种在体外模拟器官生理功能和特性的新兴技术,可利用微流体灌注培养装置再现活体器官的结构和功能单元,能够真实反映口腔组织的动态生物学过程,帮助深入理解龋齿、牙周病、口腔癌等疾病的病理机制,并评估新药的效果和安全性。本文综述了器官芯片在口腔疾病研究中的应用,重点介绍牙齿芯片、黏膜芯片、口腔癌芯片和唾液腺芯片。尽管目前面临模型标准化与成本较高等问题,器官芯片未来在口腔医学研究中的作用尤为重要。

关键词: 器官芯片, 牙齿芯片, 黏膜芯片, 口腔癌芯片, 唾液腺芯片

Abstract: The oral cavity has complex physiological characteristics and unique anatomical environment, which is difficult to accurately simulate using traditional two-dimensional in vitro models. Organ-on-a-chip technology, an emerging method that mimics the physiological functions and characteristics of organs in vitro, utilizes microfluidic perfusion systems to recreate the structure and functional units of living tissues. This approach accurately reflects the dynamic biological processes of oral tissues, aiding in the understanding of the pathological mechanisms of diseases such as dental caries, periodontitis, and oral cancer, while also assessing the efficacy and safety of new drugs. This review highlights the applications of organ-on-a-chip technology in oral disease research, focusing on dental chips, mucosal chips, oral cancer chips, and salivary gland chips. Despite current challenges such as model standardization and high costs, organ-on-a-chip technology is poised to play a significant role in future oral medical research.

Key words: organ-on-a-chip, tooth-on-a-chip, mucosa-on-a-chip, oral cancer-on-a-chip, salivary gland-on-a-chip

刘张翘楚, 黄心智. 器官芯片在口腔疾病研究中的应用[J]. 口腔医学研究, 2026, 42(1): 8-11.

LIU Zhangqiaochu, HUANG Xinzhi. Application of Organ-on-a-chip Technology in Oral Disease Research[J]. Journal of Oral Science Research, 2026, 42(1): 8-11.

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器官芯片在口腔疾病研究中的应用

Application of Organ-on-a-chip Technology in Oral Disease Research

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