变异链球菌双组分信号传导系统的研究进展

doi:10.13701/j.cnki.kqyxyj.2018.08.004

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (8): 815-817.DOI: 10.13701/j.cnki.kqyxyj.2018.08.004

变异链球菌双组分信号传导系统的研究进展

赵新元¹, 崔力^2*

1. 南方医科大学口腔医院牙体牙髓科广东广州 510280;
2. 加州大学洛杉矶分校牙医学院加州 90095

收稿日期:2017-10-24 出版日期:2018-08-28 发布日期:2018-08-23
通讯作者: 崔力,E-mail: zsucllj@ucla.edu
作者简介:赵新元(1989~ ),女,安徽六安人,硕士,主治医师,主要从事牙体牙髓病的分子生物学与组织工程学研究。
基金资助:
广东省医学科研基金(编号:B2014411),南方医科大学口腔医院院级基金课题(编号:PY2017011)

Research Progress of Stress Response-related Two Component Signal Transduction Systems of Streptococcus Mutans

ZHAO Xin-yuan¹, CUI Li^2*

1. Department of Endodontics, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China;
2. School of Dentistry, University of California, Los Angeles, California 90095, USA

Received:2017-10-24 Online:2018-08-28 Published:2018-08-23

摘要/Abstract

摘要： 龋病是一种细菌感染性疾病,变异链球菌是主要致龋菌。变异链球菌的双组分信号传导系统由膜相关组氨酸蛋白激酶和胞内反式作用因子两个基本成分组成。双组分信号传导系统可以使变异链球菌感应外界环境变化和调节内部基因表达,这对于维持细菌的生存和毒力调整有重要作用。本文就与变异链球菌应激应答密切相关的双组分信号传导系统研究现状作一综述。

关键词: 双组分信号传导系统, 应激应答, VicRK, LiaRS, CiaRH, ComDE

Abstract: Streptococcus mutans (S. mutans) is considered one of the primary etiological agents of dental caries. The two component signal transduction pathways network of S. mutans is comprised of histidine protein kinase and response regulator protein. Two component systems (TCSs) enable S. mutans to sense the environments changes and regulate the expression of important genes, which are essential for the survival and virulence adjustment of S. mutans. This article comprehensively reviews the current progress of the TCSs systems closely associated with stress response of S. mutans.

Key words: Two component signal transduction systems, Stress response, VicRK, LiaRS, CiaRH, ComDE

赵新元, 崔力. 变异链球菌双组分信号传导系统的研究进展[J]. 口腔医学研究, 2018, 34(8): 815-817.

ZHAO Xin-yuan, CUI Li. Research Progress of Stress Response-related Two Component Signal Transduction Systems of Streptococcus Mutans[J]. Journal of Oral Science Research, 2018, 34(8): 815-817.

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变异链球菌双组分信号传导系统的研究进展

Research Progress of Stress Response-related Two Component Signal Transduction Systems of Streptococcus Mutans

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