口腔医学研究

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (8): 810-813.DOI: 10.13701/j.cnki.kqyxyj.2019.08.021

• 口腔黏膜学研究 • 上一篇    下一篇

化疗诱发口腔黏膜炎的危险因素分析

李庆福1, 李锡清2, 姜丽3, 马欣1*   

  1. 1. 河南省人民医院口腔医学中心 河南 郑州 450003;
    2. 河南省人民医院肿瘤内科 河南 郑州 450003;
    3. 河南省人民医院血液内科 河南 郑州 450003
  • 收稿日期:2019-01-07 出版日期:2019-08-28 发布日期:2019-08-22
  • 通讯作者: 马欣,E-mail:13607698462@163.com
  • 作者简介:李庆福(1981~ ),男,河南南阳,硕士,主治医师,主要研究方向为口腔牙周病和黏膜病的病因及防治。
  • 基金资助:
    河南省科技厅项目(编号:142300410371)

Analysis of Risk Factors of Chemotherapy-induced Oral Mucositis

LI Qingfu1, LI Xiqing2, JIANG Li3, MA Xin1*   

  1. 1. Center of Stomatology, Henan Provincial People’s Hospital, Zhengzhou 450003, China;
    2. Department of Oncology, Henan Provincial People’s Hospital, Zhengzhou 450003, China;
    3. Department of Hematology, Henan Provincial People’s Hospital, Zhengzhou 450003, China
  • Received:2019-01-07 Online:2019-08-28 Published:2019-08-22

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摘要： 目的:探讨化疗诱发口腔黏膜炎的危险因素。方法:通过对205例恶性肿瘤需行化疗的患者的临床资料进行回顾分析,探讨患者的年龄、性别、肿瘤类型、含氟尿嘧啶(5-FU)的化疗方式、化疗强度、化疗周期、口腔急慢性疾病、口腔卫生状况、中性粒细胞数、血红蛋白水平、和是否伴有糖尿病等因素与化疗性口炎发生的相关性。结果:单因素结果分析显示化疗方式、化疗强度、化疗周期、口腔急慢性疾病、口腔卫生状况和中性粒细胞水平的比较差异具有统计学意义。进一步多因素分析显示化疗药物的强度(β=1.099,P＜0.05)、化疗周期(β=0.964,P＜0.05)、化疗方式(β=1.100,P＜0.05)、口腔急慢性疾病(β=1.180,P＜0.05)、中性粒细胞数(β=1.050,P＜0.05)是导致化疗性口炎的主要因素。结论:化疗药物的强度和周期、化疗方式、口腔急慢性疾病和中性粒细胞水平是导致化疗性口炎的危险因素。

关键词: 化疗, 口腔黏膜炎, 危险因素, 回顾性研究

Abstract: Objective: To explore the risk factors of oral mucositis induced by chemotherapy. Methods: Through retrospective analyzing the clinical data of 205 cases of malignant tumor patients who performed chemotherapy, we discussed the correlation between chemotherapy stomatitis and patient’s age, sex, tumor type, containing fluorouracil (5-FU) way of chemotherapy, the strength of chemotherapy, chemotherapy cycle, oral acute or chronic disease, oral hygiene status, the number of neutrophils, hemoglobin level, and whether associated with diabetes. Results: Univariate analysis showed that there were statistically significant differences in chemotherapy, intensity of chemotherapy, duration of chemotherapy, oral diseases, oral hygiene, and neutrophil levels. Further multivariate analysis showed that the intensity of chemotherapy drugs (β=1.099, P<0.05), duration of chemotherapy (β=0.964, P<0.05), mode of chemotherapy (β=1.100, P<0.05), acute and chronic diseases of the oral cavity (β=1.180, P<0.05), and number of neutrophils (β=1.050, P<0.05) were the main factors leading to chemotherapeutic stomatitis. Conclusion: The intensity and cycle of chemotherapeutic drugs, chemotherapy regimens, oral acute and chronic diseases, and neutrophil levels were risk factors for chemotherapeutic stomatitis.

Key words: chemotherapy, oral mucositis, risk factors, retrospective study