口腔医学研究

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (12): 1137-1140.DOI: 10.13701/j.cnki.kqyxyj.2019.12.009

• 口腔肿瘤学研究 • 上一篇    下一篇

牙龈鳞状细胞癌浸润深度与淋巴结转移的相关性研究

于颖1, 曲卫国1*, 苏颖颖2, 张茜2, 冯凯1   

  1. 1. 大连市口腔医院口腔颌面外科 辽宁 大连 116021;
    2. 大连市口腔医院病理科 辽宁 大连 116021
  • 收稿日期:2019-03-09 出版日期:2019-12-28 发布日期:2019-12-23
  • 通讯作者: 曲卫国,E-mail:qwg2002521@163.com
  • 作者简介:于颖(1993~ ),女,辽宁人,硕士,医师, 研究方向:口腔颌面外科学。

Correlation between Invasive Depth of Gingival Squamous Cell Carcinoma and Lymph Node Metastasis

YU Ying1, QU Weiguo1*, SU Yingying2, ZHANG Qian2, FENG Kai1   

  1. 1.Department of Oral and Maxillofacial Surgery, Dalian Stomatological Hospital, Dalian 116021, China;
    2. Department of Pathology, Dalian Stomatological Hospital, Dalian 116021, China.
  • Received:2019-03-09 Online:2019-12-28 Published:2019-12-23

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摘要： 目的:通过测量浸润深度和淋巴结是否转移,明确浸润深度是否可作为淋巴结转移预测因素。方法:选择明确病理诊断为牙龈鳞状细胞癌的患者,同期选择性颈淋巴清扫术的30名术前淋巴结阴性(cN0)患者纳入研究。对牙龈鳞状细胞癌患者的临床因素(年龄、性别、T分类)和病理学因素(浸润深度、分化程度、侵袭方式、癌周淋巴细胞密度)进行回顾性分析。结果:单因素Logistic回归分析结果表明浸润深度和肿瘤侵袭方式与淋巴结转移相关,而性别、年龄、病理分级、cTNM分期、癌周淋巴细胞浸润密度与淋巴结转移无明显相关性。多因素Logistic回归分析结果显示只有浸润深度为颈部淋巴结转移的独立预测因子。结论:浸润深度是牙龈鳞状细胞癌颈部区域性淋巴结转移的重要相关因素,对评估区域性淋巴结转移有重要意义,可作为淋巴结转移的预测因子。

关键词: 浸润深度, 淋巴结转移, 牙龈鳞状细胞癌

Abstract: Objective: To analyze the correlation between infiltration depth and other related influencing factors and lymph node metastasis, and to determine whether the depth of invasion can be used as a predictor of lymph node metastasis. Methods: Thirty patients with gingival squamous cell carcinoma were enrolled in the study. 30 patients with preoperative lymph node negative (cN0) were enrolled in the study. The clinical factors (age, gender, T classification) and pathological factors (invasion depth, degree of differentiation, invasion mode, and peritumoral lymphocyte density) of gingival squamous cell carcinoma were reviewed. Results: Univariate logistic regression analysis showed that the depth of invasion and tumor invasion were correlated with lymph node metastasis. There was no significant correlation between gender, age, pathological grade, cTNM stage, and peritumoral lymphocyte infiltration density and lymph node metastasis. In multivariate logistic regression analysis, only the depth of invasion was an independent predictor of cervical lymph node metastasis. Conclusion: Invasion depth is an important factor in the regional lymph node metastasis of gingival squamous cell carcinoma. It is important for the evaluation of regional lymph node metastasis and can be used as a predictor of lymph node metastasis.

Key words: depth of invasion, lymph node metastasis, gingival squamous cell carcinoma