化学交联剂对树脂牙本质粘接稳定性的影响

doi:10.13701/j.cnki.kqyxyj.2020.03.003

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (3): 203-205.DOI: 10.13701/j.cnki.kqyxyj.2020.03.003

化学交联剂对树脂牙本质粘接稳定性的影响

钱鑫, 张志民^*

吉林大学口腔医院牙体牙髓病科吉林长春 130000

收稿日期:2019-09-09 出版日期:2020-05-15 发布日期:2020-05-15
通讯作者: 张志民,E-mail:zhangzm1964@sina.com
作者简介:钱鑫(1994~),女,吉林人,硕士在读,研究方向:口腔材料学。

Effect of Chemical Crosslinking Agent on Adhesive Stability of Resin-dentin Bonding

QIAN Xin, ZHANG Zhimin^*

Department of Endodontics Hospital of Stomatology, Jilin University, Changchun 130021, China

Received:2019-09-09 Online:2020-05-15 Published:2020-05-15

摘要/Abstract

摘要： 随着粘接剂的发展口腔粘接修复在临床得到广泛应用。但牙本质粘接耐久性的问题仍然不容乐观。由于口腔各种酶、细菌等多种因素会导致粘接界面胶原纤维暴露,而裸露的胶原纤维极易降解和疲劳破坏,从而影响牙本质粘接稳定性。基质金属蛋白酶介导的对胶原纤维的降解是粘接界面破坏的主要因素。抑制基质金属蛋白酶活性、增强胶原性能是延长粘接寿命的关键。为此,针对口腔牙本质粘接难点的问题,基于牙本质生物改性的概念,通过使用胶原交联剂的生物活性介导的仿生方法,改变牙本质生物理化性能来强化牙本质胶原纤维强度,增加粘接稳定性。本文主要介绍牙本质生物改性及其相关的基质成分,并对化学胶原交联剂碳化二亚胺及戊二醛进行了综述。

关键词: 牙本质生物改性, 交联剂, 碳化二亚胺, 戊二醛, 耐久性

Abstract: Oral adhesion repair has been widely used with the development of adhesives.But the problem of dentin adhesion durability is not optimistic.Various enzymes, bacteria, and other factors in the oral cavity may lead to the exposure of collagen fibers at the bonding interface, and the exposed collagen fibers are easily degraded and damaged by fatigue, thus affecting the stability of dentin bonding.Matrix metalloproteinase-mediated degradation of collagen fibers is the main factor of adhesion interface damage.Inhibition of matrix metalloproteinase activity and enhancement of collagen properties are the keys to prolong the bonding life.Therefore, in view of the difficulties in the adhesion of oral dentin, based on the concept of biological modification of dentin, the bionic method mediated by the biological activity of collagen cross-linking agent was used to change the biological and physical properties of dentin to strengthen the strength of dentin collagen fiber and increase the adhesion stability.In this paper, the role of crosslinkers in the biological modification of dentin was introduced.

Key words: dentin biomodification, cross-linking agent, carbodiimide, glutaraldehyde, durability

钱鑫, 张志民. 化学交联剂对树脂牙本质粘接稳定性的影响[J]. 口腔医学研究, 2020, 36(3): 203-205.

QIAN Xin, ZHANG Zhimin. Effect of Chemical Crosslinking Agent on Adhesive Stability of Resin-dentin Bonding[J]. Journal of Oral Science Research, 2020, 36(3): 203-205.

参考文献

[1] Mazzoni A, Angeloni V, Sartori N, et al. Substantivity of carbodiimide inhibition on dentinal enzyme activity over time[J]. J Dent Res, 2017, 96(8):902-908.
[2] Parise Gré C, Pedrollo Lise D, Ayres AP,et al. Do collagen cross-linkers improve dentin’s bonding receptiveness?[J]. Dent Mater, 2018, 34(11):1679-1689.
[3] Chiang YS, Chen YL, Chuang SF, et al. Riboflavin-ultraviolet-A-induced collagen cross-linking treatments in improving dentin bonding[J]. Dent Mater, 2013, 29(6):682-692.
[4] Singh P, Nagpal R, Singh UP, et al. Effect of carbodiimide on the structural stability of resin/dentin interface[J]. J Conserv Dent, 2016, 19(6):501-509.
[5] Pashley DH, Tay FR, Yiu C, et al. Collagen degradation by host-derived enzymes during aging[J]. J Dent Res, 2004, 83(3):216-221.
[6] 贾玲玲, 万乾炳. 基质金属蛋白酶抑制剂的研究进展[J]. 华西口腔医学杂志, 2008, 35(2):219-226.
[7] Hass V, de Paula AM, Parreiras S, et al. Degradation of dentin-bonded interfaces treated with collagen cross-linking agents in a cariogenic oral environment: An in situ study[J]. J Dent, 2016, 49:60-67.
[8] De Munck J, Van den Steen PE, Mine A, et al. Inhibition of enzymatic degradation of adhesive-dentin interfaces[J]. J Dent Res, 2009, 88(12):1101-1106.
[9] Tjäderhane L, Nascimento FD, Breschi L, et al. Strategies to prevent hydrolytic degradation of the hybrid layer-A review[J]. Dent Mater, 2013, 29(10):999-1011.
[10] Bedranrusso AK, Vidal CM, Dos Santos PH, et al. Long-term effect of carbodiimide on dentin matrix and resin-dentin bonds[J]. J Biomed Mater Res B Appl Biomater, 2010, 94(1):250-255.
[11] Al-Ammar A, Drummond JL, Bedran-Russo AK. The use of collagen cross-linking agents to enhance dentin bond strength[J]. J Biomed Mater Res B Appl Biomater, 2010, 91(1):419-424.
[12] Scheffel D, Delgado C, Soares DG, et al. Increased durability of resin-dentin bonds following cross-linking treatment[J]. Oper Dent, 2015, 40(5):533-539.
[13] Shafiei F, Yousefipour B, Mohammadi-Bassir M. Effect of carbodiimide on bonding durability of adhesive-cemented fiber posts in root canals[J]. Oper Dent, 2016, 41(4):432-440.
[14] Hass V, Luque-Martinez IV, Gutierrez MF, et al. Collagen cross-linkers on dentin bonding: Stability of the adhesive interfaces, degree of conversion of the adhesive, cytotoxicity and in situ MMP inhibition[J]. Dent Mater, 2016, 32(6):732-741.
[15] Mazzoni A, Angeloni V, Comba A, et al. Cross-linking effect on dentin bond strength and MMPs activity[J]. Dental Materials, 2017, 34(2):288-295.
[16] Scheffel DL, Hebling J, Scheffel RH, et al. Stabilization of dentin matrix after cross-linking treatments, in vitro[J]. Dent Mater, 2014, 30(2):227-233.
[17] Scheffel DL, Bianchi L, Soares DG, et al. Transdentinal cytotoxicity of carbodiimide (EDC) and glutaraldehyde on odontoblast-like cells[J]. Oper Dent, 2015, 40(1):44-54.
[18] Zhang Z, Beitzel D, Majd H, et al. Fatigue resistance of dentin bonds prepared with two- vs. three-step adhesives: effect of carbodiimide[J]. Dent Mater, 2017, 33(12):1340-1350.
[19] Tang L, Zhang Y, Liu Y, et al. Influence of EDC on dentin-resin shear bond strength and demineralized dentin thermal properties[J]. Materials (Basel), 2016, 9(11). pii: E920.
[20] Ryou H, Turco G, Breschi L, et al. On the stiffness of demineralized dentin matrices[J]. Dental Materials, 2016, 32(2):161-170.
[21] Bowes JH, Cater CW. The interaction of aldehydes with collagen[J]. Biochimica Et Biophysica Acta, 1968, 168(2):341-352.
[22] Sung HW, Chang Y, Chiu CT, et al. Crosslinking characteristics and mechanical properties of a bovine pericardium fixed with a naturally occurring crosslinking agent[J]. J Biomed Mater Res, 2015, 47(2):116-126.
[23] Macedo GV, Yamauchi M, Bedranrusso AK. Effects of chemical cross-linkers on caries-affected dentin bonding[J]. J Dent Res, 2009, 88(12):1096-1100.
[24] Sato K, Taguchi H, Maeda T, et al. The primary cytotoxicity in ultraviolet-a-irradiated riboflavin solution is derived from hydrogen peroxide[J]. J Invest Dermatol, 1995, 105(4):608-612.
[25] Khor E. Methods for the treatment of collagenous tissues for bioprostheses[J]. Biomaterials, 1997, 18(2):95-105.
[26] Scheffel DL, Soares DG, Basso FG, et al. Transdentinal cytotoxicity of glutaraldehyde on odontoblast-like cells[J]. J Dent, 2015, 43(8):997-1006.
[27] Bedran-Russo AK, Pashley DH, Agee K, et al. Changes in stiffness of demineralized dentin following application of collagen crosslinkers[J]. J Biomed Mater Res B Appl Biomater, 2008, 86(2):330-334.
[28] Farias D, Miguez PA, Swift EJ Jr. Critical appraisal: Cross-linkers and the dentin matrix[J]. J Esthet Restor Dent, 2014, 26(1):72-76.

化学交联剂对树脂牙本质粘接稳定性的影响

Effect of Chemical Crosslinking Agent on Adhesive Stability of Resin-dentin Bonding

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 2

编辑推荐

Metrics

[1]	刘雯, 刘敏, 邓婷, 王雯, 郑月梅, 郭玲, 谢翠柳. 原花青素对不同深度牙本质粘接耐久性的影响[J]. 口腔医学研究, 2020, 36(4): 372-376.
[2]	王丽霞, 赵寰, 靳淑凤, 申静, 丁一. EDC交联离子化胶原支架材料的生物学表征[J]. 口腔医学研究, 2015, 31(4): 343-348.