口腔医学研究

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (6): 558-562.DOI: 10.13701/j.cnki.kqyxyj.2020.06.013

• 口腔颌面外科学研究 • 上一篇    下一篇

口颌面部孤立性纤维性肿瘤的临床分析及手术探讨

王丹妮1, 孙国文1*, 田美1, 陈昊亮1, 翟一伟1, 张磊2   

  1. 1.南京大学医学院附属口腔医院,南京市口腔医院口腔颌面外科 210008;
    2.南京大学医学院附属口腔医院,南京市口腔医院病理科 210008
  • 收稿日期:2019-09-18 出版日期:2020-07-03 发布日期:2020-07-06
  • 通讯作者: *孙国文,E-mail:238957@sina.com
  • 作者简介:王丹妮(1994~ ),女,安徽黄山人,硕士在读,研究方向:口腔颌面外科。
  • 基金资助:
    江苏省卫生厅课题项目(编号:H201441);南京市科技发展计划项目(编号:201503038)

Clinical Analysis and Treatment of Solitary Fibrous Tumors in Oral and Maxillofacial Region

WANG Dani1, SUN Guowen1*, TIAN Mei1, CHEN Haoliang1, ZHAI Yiwei1, ZHANG Lei2   

  1. 1. Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital affiliated to Nanjing University, Nanjing 210008, China;
    2. Department of Pathology, Nanjing Stomatological Hospital Affiliated to Nanjing University, Nanjing 210008, China
  • Received:2019-09-18 Online:2020-07-03 Published:2020-07-06

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摘要： 目的: 通过对口颌面部孤立性纤维性肿瘤的临床病例回顾性分析及手术探讨,以提高该疾病的临床诊疗水平。方法: 对2015年6月~2019年6月间收入南京大学附属南京市口腔医院病理数据库的颌面部孤立性纤维性肿瘤病例进行回顾性分析,分析患者的临床病史,影像、病理资料,治疗方法及随访资料。结果: 共有8例患者依靠术后病理确诊为孤立性纤维性肿瘤。2例术后病理为低度恶性的肿瘤患者,1例外院术后复发,于本院行手术后随访未见复发,1例术后随访发现复发。结论: 手术完整切除是治疗颌面部孤立性纤维性肿瘤的首选方法,当发现颌面部孤立性纤维性肿瘤好发部位有软组织肿块,且影像强化明显时,应考虑有孤立性纤维性肿瘤的可能,最终确诊需依靠病理及免疫组化检查。临床上应警惕具有侵袭性或恶性的颌面部孤立性纤维性肿瘤,术后密切随访,若存在复发情况应及时手术。

关键词: 口腔颌面部肿瘤, 孤立性纤维性肿瘤, 外科手术, 回顾性分析

Abstract: Objective: To improve the level of clinical diagnosis and treatment by retrospective analyzing the clinical cases of solitary fibrous tumor in oral and maxillofacial region. Methods: A retrospective analysis was conducted on the maxillofacial solitary fibroma, which was included in the pathological database of Nanjing Stomatological Hospital affiliated to Nanjing University from June 2015 to June 2019. The clinical data, imaging data, pathological data, treatment methods, and follow-up data of the patients were analyzed. Results: A total of 8 patients were diagnosed as solitary fibrous tumor in oral and maxillofacial region by postoperative pathology. Of the 2 patients whose postoperative pathology was low grade malignant tumor, 1 had recurrence in other hospital, but no recurrence was found in our hospital at present, and 1 patient had recurrence in postoperative follow-up. Conclusion: Complete resection is the first choice for the treatment of solitary fibroma of maxillofacial region. When it is found that solitary fibroma of the maxillofacial area is prone to soft tissue masses and the imaging enhancement is obvious, the possibility of solitary fibroma should be considered, and the final diagnosis should rely on pathological and immunohistochemical examination. Clinically, patients should be alerted to the invasive or malignant solitary fibroma of the maxillofacial region. Patients should be followed up closely after surgery, and timely surgery should be carried out if recurrence exists.

Key words: oral and maxillofacial tumor, solitary fibrous tumor, surgical procedures, retrospective analysis