N6-甲基腺嘌呤RNA甲基化在口腔发育及相关疾病中的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.09.003

口腔医学研究 ›› 2023, Vol. 39 ›› Issue (9): 775-779.DOI: 10.13701/j.cnki.kqyxyj.2023.09.003

N6-甲基腺嘌呤RNA甲基化在口腔发育及相关疾病中的研究进展

黄璟, 周毅^*

口颌系统重建与再生全国重点实验室,口腔生物医学教育部重点实验室,口腔医学湖北省重点实验室,武汉大学口腔医(学)院湖北武汉 430079

收稿日期:2022-12-05 出版日期:2023-09-28 发布日期:2023-09-25
通讯作者: *周毅,E-mail:dryizhou@whu.edu.cn
作者简介:黄璟(1991~ ),男,江西抚州人,博士,主治医师,研究方向:牙周炎、口腔再生医学。
基金资助:
湖北省自然科学基金(编号:2022CFB115);国家自然科学基金(编号:82001014,82071090)

Advances of N6-methyladenine RNA Methylation in Oral Development and Diseases

HUANG Jing, ZHOU Yi^*

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

Received:2022-12-05 Online:2023-09-28 Published:2023-09-25

摘要/Abstract

摘要： 表观遗传调控是指在遗传物质序列不变的情况下,通过表观遗传修饰方式调节基因表达水平。N6-甲基腺嘌呤(N6-methyladenosine,m6A)RNA甲基化是其中的一种,由甲基转移酶、去甲基化酶和识别蛋白作用于目标RNA,调控其表达水平。本文将回顾m6A及其调节分子在口腔发育及再生、口腔炎症性疾病、口腔肿瘤中的作用及机制。

关键词: 表观遗传, m6A修饰, m6A调节分子, 目标RNA

Abstract: Epigenetic regulation refers to the regulation of gene expression through epigenetic modification without alteration of genetic material sequence. N6-methyladenosine (m6A) RNA methylation is one of regulation approaches. The expression level of target RNA is modified by methyltransferase, demethylase, and recognition protein. This article reviews the role and mechanism of m6A and its regulatory molecules in oral development and regeneration, oral inflammatory diseases, and oral tumor diseases.

Key words: epigenetics, m6A modification, m6A regulators, target RNA

黄璟, 周毅. N6-甲基腺嘌呤RNA甲基化在口腔发育及相关疾病中的研究进展[J]. 口腔医学研究, 2023, 39(9): 775-779.

HUANG Jing, ZHOU Yi. Advances of N6-methyladenine RNA Methylation in Oral Development and Diseases[J]. Journal of Oral Science Research, 2023, 39(9): 775-779.

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N6-甲基腺嘌呤RNA甲基化在口腔发育及相关疾病中的研究进展

Advances of N6-methyladenine RNA Methylation in Oral Development and Diseases

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