金属离子掺杂的硅磷酸钙陶瓷在骨修复领域的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.10.004

摘要/Abstract

摘要： 因牙周疾病、肿瘤、外伤、先天畸形所致的口腔硬组织缺损给口腔功能重建带来极大困难。硅磷酸钙[Ca₅(PO₄)₂SiO₄,简称CPS]生物陶瓷因其良好的生物相容性、可降解性、骨传导性和骨诱导性,成为新一代骨缺损修复材料的研究热点。天然人体矿化组织中含有Cu²⁺、Fe³⁺、Zn²⁺、Mg²⁺、Sr²⁺等多种金属离子,具有其独特的生物特性,将这些金属离子加入到硅磷酸钙中对于材料改性有着巨大的潜力。本文概述了目前针对硅磷酸钙性能的研究进展,重点介绍了离子掺杂对生物陶瓷理化性质的影响及金属离子在抗菌、促进成骨和新血管生成等方面的作用及其可能机制,并对硅磷酸钙类材料今后的发展方向做一展望。

关键词: 硅磷酸钙, 离子掺杂, 生物陶瓷, 骨组织修复

Abstract: Oral hard tissue defects caused by periodontal diseases, tumors, trauma, and congenital malformations bring great difficulties to the reconstruction of oral function. Silicocarnotite [Ca₅(PO₄)₂SiO₄,CPS] bioceramics have become the research hotspot of new generation of bone defects restoration materials due to their good biocompatibility, degradability, osteoconductivity, and bone conductivity. Natural human mineralized tissues contain various metal ions such as Cu²⁺, Fe³⁺, Zn²⁺, Mg²⁺, Sr²⁺, etc, which have their unique biological properties, and the incorporation of these metal ions into silicocarnotite has great potential for material modification. This paper outlines the current investigations of silicocarnotite bioceramics, focusing on the effects of ion doping on the physicochemical properties of bioceramics, the role of metal ions in antibiosis and promoting osteogenesis and neoangiogenesis, and their possible mechanisms, and provides an outlook on the future development of silicocarnotite-based materials.

Key words: silicocarnotite, ion doping, bioceramics, bone tissue repair

李欣睿, 孟维艳. 金属离子掺杂的硅磷酸钙陶瓷在骨修复领域的研究进展[J]. 口腔医学研究, 2023, 39(10): 871-874.

LI Xinrui, MENG Weiyan. Research Progress of Metal Ion Doped Silicocarnotite Bioceramics in Field of Bone Repair[J]. Journal of Oral Science Research, 2023, 39(10): 871-874.

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