口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (11): 1129-1132.

• 临床研究论著 • 上一篇    下一篇

新型骨修复材料修复种植牙骨缺损的前瞻性临床研究

陈冬1,白轶1,李蓉1,张玉峰1,夏海斌1,施斌1*,童昕2,邓春富3,尹力强4   

  1. 1. 武汉大学口腔医学院种植科 湖北 武汉 430079;
    2. 南京大学医学院附属口腔医院 江苏 南京 210008;
    3. 中国医科大学口腔医院种植中心 辽宁 沈阳 110002;
    4. 烟台正海生物技术有限公司 山东 烟台 264000
  • 收稿日期:2015-02-09 出版日期:2015-11-28 发布日期:2016-03-21
  • 通讯作者: 施斌,电话:(027)87686600
  • 作者简介:陈冬(1981~),男,湖北人,主治医师,博士,主要从事口腔种植学研究。

Prospective Clinical Research of A New Bone Substitutes in Repairing Alveolar Bone Defects.

CHEN Dong1, BAI Yi1, LI Rong1, ZHANG Yu-feng1, XIA Hai-bin1, SHI Bin1*, TONG Xin2, DENG Chun-fu3, YIN Li-qiang4.   

  1. 1. Hospital of Stomatology,Wuhan University, Wuhan430079, China;2. Nanjing Stomatological Hospital,Medical School of Nanjing University,Nanjing 210008, China; 3. Impantation Center, Stomatology Hospital,China Medical University,Shenyang 110002, China; 4. Yantai Zhenghai Biotechnology Company,Yantai 264000, China
  • Received:2015-02-09 Online:2015-11-28 Published:2016-03-21

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摘要： 目的:观察一种新型骨修复材料和Bio-oss骨粉修复牙种植骨缺损的早期临床疗效。方法:采用盲法、平行对照,按随机代码表分配入组患者的前瞻性临床试验设计。试验组90例接受新型骨修复材料治疗,对照组90例接受Bio-oss骨粉治疗。分别于术前、术后当天、术后6个月在选定的同一骨缺损区进行CBCT影像学检查,计算骨体积转化有效率(骨体积转化率80%的病例数/总病例数),将其作为骨缺损修复效果的判定标准。结果:术后6个月,试验组骨体积转化有效率为85.39%,对照组骨体积转化有效率为82.95%,试验组的骨体积转化有效率与对照组的骨体积转化有效率无统计学差异(P=0.0117);术后6个月与术中骨密度两组差异无统计学意义,认为两组间新生骨密度相似。结论:新型骨修复材料和Bio-oss骨粉用于种植牙骨缺损的填充修复效果均获得较好的临床疗效,并且未发生不良反应。该新型骨修复材料是一种临床可供选择使用的的骨移植修复材料。

Abstract: Objective: To compare the restoration effect of a new deproteinized mineral bovine bone and Bio-oss bone in the bone defect around dental implant. Methods: The prospective clinical trial design was blinded, random, open, and parallel control. 180 patients were divided into two groups randomly. In the experimental group, 90 patientswere treated with a new deproteinized mineral bovine bone and Bio-gide. In the control group, 90 patients were treated with Bio-oss bone dust and Bio-gide. The patients were checked by CT at pre-operation, the day of surgery, and 6 months after surgery. The effective bone turnover rate was counted asthe ratio of cases equalorgreaterthan 80% of bone turnover rate to the total cases.It was used as the criteriato evaluate the effect of bone substitutes. Results: At postoperative 6 months, the bone conversion efficiency rate of test group was 85.39%, which was higher than that of control group (82.95%, P=0.0117). However, on the time of surgery, there was no significant difference between the experimental and control groups. Conclusion: New deproteinized mineral bovine bone and Bio-oss bone dust have the same clinical effect on repairing alveolar bone defect around dental implant. Both of them have no side effect.

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