牙丧失与食管癌的相关性:一项基于病例-对照研究的Meta分析

摘要/Abstract

摘要： 目的:采用Meta分析的方法讨论牙丧失与食管癌的相关性。方法:计算机检索PubMed与CNKI数据库自建库以来至2015年1月10日期间公开发表的探究牙丧失与食管癌性关系的病例-对照研究。由2位评价员按照纳入与排除标准独立筛选文献、提取资料。Meta分析采用RevMan 5.3软件进行,并对研究的发表偏倚进行了检测。结果:最终纳入4篇符合要求的文献包含5项病例对照研究。Meta分析结果提示牙丧失使得罹患食管癌的风险性增加了1.44倍(OR=1.44,95%CI=1.23-1.68,P<0.001);亚组分析的结果同样证实了上结论,且未发现发表偏倚。结论:牙丧失可能是食管癌的是一个重要的相关危险因素。因此,牙丧失人群应高度警惕食管癌的相关症状。

Abstract: Objective: To evaluate the association between tooth loss and esophageal cancer (EC). Methods: We conducted electronic searches of PubMed and CNKI until January 10, 2015 to identify relevant case-control studies on the association between tooth loss and the risk of EC. Study selection and data extraction from eligible studies were independently performed by 2 investigators. The meta-analysis was conducted using RevMan 5.3 software. Publication bias was also investigated. Results: Four eligible publications with 5 case-control studies were included. The results of meta-analysis identified that tooth loss increased the risk of EC by 1.44 times (Odds ratio: 1.44, 95% confidence interval: 1.23-1.68, P<0.001). Subgroup analysis proved similar results and publication bias was not detected. Conclusion: Based on the current evidences, tooth loss could be considered as a significant and dependent risk factor for EC. Therefore, the population with tooth loss should be vigilant for symptoms of EC.

中图分类号:

R781.4

杨盛军,雷志敏. 牙丧失与食管癌的相关性:一项基于病例-对照研究的Meta分析[J]. 口腔医学研究, 2015, 31(11): 1125-1128.

YANG Sheng-jun, LEI Zhi-min.. Association Between Tooth Loss and Esophageal Cancer: A Meta-analysis of Case-control Studies.[J]. Journal of Oral Science Research, 2015, 31(11): 1125-1128.

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