纤维连接蛋白EDA片段的病理学研究进展

doi:10.13701/j.cnki.kqyxyj.2016.05.029

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (5): 538-540.DOI: 10.13701/j.cnki.kqyxyj.2016.05.029

纤维连接蛋白EDA片段的病理学研究进展

杨月¹ ,王海丞¹ ,彭靖¹ ,李翠英^1* ,江久汇^2*

1. 北京大学口腔医学院中心实验室北京 100081;
2. 北京大学口腔医学院正畸科北京 100081

收稿日期:2015-02-06 出版日期:2016-05-26 发布日期:2016-05-26
通讯作者: 李翠英,E-mail:licuiying_67@163.com江久汇,E-mail:drjiangw@163.com
作者简介:杨月(1989~ ),女,回族,山东泰安人,硕士在读,主要从事组织病理学的研究工作。
基金资助:
国家自然科学基金资助项目(303075717)(303075816)

Pathologic Research Progress of Fibronectin EDA.

YANG Yue¹, WANG Hai-cheng¹, PENG Jin¹, LI Cui-ying^1*, JIANG Jiu-hui^2*.

1. The Central Laboratory, Peking University School and Hospital of Stomatology, Haidian District, Beijing;
2. The Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, China

Received:2015-02-06 Online:2016-05-26 Published:2016-05-26

摘要/Abstract

摘要： 细胞外基质纤维连接蛋白基因Ⅲ型重复序列有3个可变剪接区,分别为EDA、 EDB和IIICS。在肿瘤、胚胎及创伤愈合等细胞增殖和迁移活跃的组织中, EDA+FN呈高表达,而正常组织中几乎不表达。本文就其特性、生物学功能和临床应用前景进行综述。

关键词: EDA, 纤维连接蛋白, 可变剪接

Abstract: Fibronectin is an adhesive extracellular matrix glycoprotein. Its primary gene transcription is alternatively spliced in three regions: designated EDA, EDB and IIICS. EDA is associated with a variety of cellular processes, such as embryogenesis, malignancy and wound healing. Here we discuss the biological properties and possible application of EDA.

中图分类号:

R780.2

杨月 ,王海丞 ,彭靖 ,李翠英 ,江久汇. 纤维连接蛋白EDA片段的病理学研究进展[J]. 口腔医学研究, 2016, 32(5): 538-540.

YANG Yue, WANG Hai-cheng, PENG Jin, LI Cui-ying, JIANG Jiu-hui.. Pathologic Research Progress of Fibronectin EDA.[J]. Journal of Oral Science Research, 2016, 32(5): 538-540.

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纤维连接蛋白EDA片段的病理学研究进展

Pathologic Research Progress of Fibronectin EDA.

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