口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (5): 494-496.DOI: 10.13701/j.cnki.kqyxyj.2016.05.017

• 临床研究论著 • 上一篇    下一篇

淀粉样变性55例口腔临床病理观察

徐刚1* ,崔全才2 ,杜德顺1   

  1. 1. 中国医学科学院·北京协和医学院·北京协和医院口腔科 北京 100032;
    2. 中国医学科学院·北京协和医学院·北京协和医院病理科 北京 100730
  • 收稿日期:2015-09-18 出版日期:2016-05-26 发布日期:2016-05-26
  • 通讯作者: 徐刚,E-mail:xugang8140@sina.com
  • 作者简介:暋徐刚(1974~ ),男,黑龙江齐齐哈尔人,硕士,主治医师,主要从事口腔科的临床治疗工作。

Clinicopathological Observation of Oral Tissue of 55 Amyloidosis Cases.

XU Gang1, CUI Quan-cai2, DU De-shun1.   

  1. 1. Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science &Peking Union Medical College, Beijing 100032, China;
    2. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science &Peking Union Medical College, Beijing 100730, China
  • Received:2015-09-18 Online:2016-05-26 Published:2016-05-26

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摘要： 目的:探讨淀粉样变性在口腔颌面部的临床病理特点及口腔组织活检于淀粉样变性诊断的意义。方法:回顾性分析55例淀粉样变性的口腔临床特点和活检切片的HE染色,刚果红特染,光镜和偏光镜观察,免疫组织化学染色和一淀粉样变性肾组织活检的电镜检查。结果:在总计55例中,46例口腔组织(牙龈、舌、下唇、唇腺)活检切片可见淀粉样物质沉积。口腔组织的活检阳性率为84%。口腔组织切片检查可见黏膜基底膜下、舌肌间粉红均质淀粉样物质沉积,刚果红特染呈砖红色。透色电镜观察淀粉样蛋白为排列不规则,不均匀的絮状结构。结论:淀粉样变性在口腔组织表现主要呈舌体增大、质硬、溃疡。口腔组织活检可提供淀粉样变性病诊断重要依据。

关键词: 淀粉样变性, 病理, 刚果红

Abstract: Objective: To investigate the clinicopathological characteristics of amyloidosis in the oral and maxillofacial region and evaluate the value of oral tissue biopsy to the diagnosis of amyloidosis. Methods: The clinical data of 55 amyloidosis cases from May 2010 to December 2014 were retrospectively analyzed. Oral tissue biopsy was applied for all of the patients by the authors and was analyzed by HE staining, alkaline Congo red staining and immunohistochemical staining. All sections were examined by transmitted and polarized light microscopy. One kidney biopsy tissue was observed via transmitted electron microscopy (TEM). Results: 46 oral tissue biopsy (gingival, glossa, lip and gland) presented positive outcome of amyloidosis with the positive rate of 84%. The amyloidosis was characterized as pink amyloid protein deposition under the basement membrane and in the wall of blood vessles, and was presented brick-like red by alkaline Congo red staining. The TEM results showed that the amyloid protein appeared like irregular and uneven flocculent structure. Conclusion: The amyloidosis in the oral and maxillofacial region mainly manifests enlargement, solidness and ulceration of the tongue. Oral tissue biopsy can provide an important evidence for amyloidosis disease diagnosis.

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