舍格伦综合征患者唾液MMP-9表达与组织病理分级相关性研究

doi:10.13701/j.cnki.kqyxyj.2017.12.016

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (12): 1302-1305.DOI: 10.13701/j.cnki.kqyxyj.2017.12.016

舍格伦综合征患者唾液MMP-9表达与组织病理分级相关性研究

夏萍^1,2,张梅兮¹,穆森¹,张瑞杰³,柴琳¹,詹渊博¹,张瑞敏^1*

1. 哈尔滨医科大学附属第二医院牙周黏膜科黑龙江哈尔滨 150086;
2. 白城医学高等专科学校口腔学院吉林白城 137000;
3. 哈尔滨医科大学生物信息与科学技术学院黑龙江哈尔滨 150086

收稿日期:2017-07-03 出版日期:2017-12-20 发布日期:2018-01-03
通讯作者: 张瑞敏,电话:(0451)86297061
作者简介:夏萍(1983~ ),女,黑龙江佳木斯人,主治医师,硕士在读,主要从事口腔牙周病和黏膜病的临床研究。
基金资助:
哈尔滨市应用技术研究与开发项目(编号:2014RFXGJ100)

Correlative Study on Expression of Saliva Matrix Metalloprotase 9 in Patients with Sjogren Syndrome and Histopathologic Grading.

Xia Ping^1,2, Zhang Mei-xi¹, Mu Sen¹, Zhang Rui-jie³, Chai Lin¹, Zhan Yuan-bo¹, Zhang Rui-min^1*.

1. Department of Periodontal Mucosa, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China;
2. Department of Stomatology, Baicheng Medical College, Baicheng 137000, China;
3. Department of Biological Information and Sciencee Technology, Harbin Medical University, Harbin 150086, China.

Received:2017-07-03 Online:2017-12-20 Published:2018-01-03

摘要/Abstract

摘要： 目的: 观察基质金属蛋白酶9(MMP-9)在舍格伦综合征病人唾液中的表达情况,分析其与组织病理分级的相关性,探讨唾液中MMP-9水平作为舍格伦综合征特异性标志物的可能性。方法: 采集27例舍格伦综合征患者(实验组)和29例下唇黏液囊肿患者(对照组)的唾液,应用酶联免疫吸附试验(ELISA)检测其MMP-9的表达水平,其中实验组按照病理分级严重程度分为病理分级低的1、2级以及病理分级高的3、4级患者。结果: 实验组患者唾液中MMP-9表达水平高于对照组,两组之间表达水平结果比较差异有统计学意义;病理分级高的舍格伦综合征患者组唾液中MMP-9水平高于病理分级低的患者组,两组比较差异有统计学意义。结论: 唾液中MMP-9表达水平可能成为舍格伦综合征的一项检测指标,并为临床诊治提供参考依据。

关键词: 舍格伦综合征, 唾液, MMP-9, 病理分级

Abstract: Objective: To research the expression of matrix metalloprotase 9 (MMP-9) in the saliva and the relationship with histopathologic grading of patients with Sjogren Syndrome. Methods: The expressions of MMP-9 in the saliva of 27 Sjogren Syndrome patients (experimental group) and 29 underlip mucocele patients (control group) were detected with ELISA and the results of Sjogren Syndrome patients were pathological graded with low level (1 and 2) and high level (3 and 4). Results: In contrast to control group, the MMP-9 levels in Sjogren Syndrome patients were significantly increased (P<0.05), and the level of MMP-9 in the high pathologic grade was higher than that of low grade (P<0.05). Conclusion: The level of MMP-9 in the saliva may be a test indicator for the Sjogren Syndrome, which might provide reference for clinical diagnosis and treatment.

Key words: Sjogren syndrome, Saliva , MMP-9 , Pathological grading

中图分类号:

R780.2

夏萍,张梅兮,穆森,张瑞杰,柴琳,詹渊博,张瑞敏. 舍格伦综合征患者唾液MMP-9表达与组织病理分级相关性研究[J]. 口腔医学研究, 2017, 33(12): 1302-1305.

Xia Ping, Zhang Mei-xi, Mu Sen, Zhang Rui-jie, Chai Lin, Zhan Yuan-bo, Zhang Rui-min.. Correlative Study on Expression of Saliva Matrix Metalloprotase 9 in Patients with Sjogren Syndrome and Histopathologic Grading.[J]. Journal of Oral Science Research, 2017, 33(12): 1302-1305.

参考文献

[1] 王璐,李霞.舍格伦综合征口干症的研究进展[J].国际口腔医学杂志,2016,43(3)∶314-317
[2] Feltsan T, Stanko P, Mracna J. Sj gren’s syndrome in present [J]. Bratisl Lek Listy, 2012,113(8)∶514-516
[3] Baldini C, Pepe P, Quartuccio L, et al. Primary Sj gren’s syndrome as a multi-organ disease: impact of the serological profile on the clinical presentation of the disease in a large cohort of Italian patients [J]. Rheumatology (Oxford), 2014, 53(5)∶839-844
[4] 李桐,袁国华,聂敏,等.MMP-9基因敲除小鼠磨牙牙胚中釉原蛋白和成釉蛋白表达的研究[J].口腔医学研究,2016,32(11)∶1117-1121
[5] Yixuan Gong,Uma D.Roles of Matrx Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression [J]. Cancer Res,2014,6(3)∶1298-1327
[6] Fernando Llambes, Santiago Arias-Herrera, Raul Caffesse, et al. Relationship between diabetes and periodontal infection [J]. World J Diabetes,2015,6(7)∶927-935
[7] Novakovie N, Todorovic T, Rakic M, et al. Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome [J]. Periodontal Res,2014,49(1)∶129-136
[8] 俞洁,章功杰,陈松军,等.糖尿病患者唾液流率与口干相关性研究[J].口腔医学研究杂志, 2016,32(2)∶177-180
[9] Gandia M, Morales-Espinoza EM, Martin-Gonzalez RM, et al. Factors influencing dry mouth in patients with primary sj gren syndrome: usefulness of the ESSPRI index [J]. Oral Health Manaq, 2014, 13(2)∶402-407
[10] Nocturne G, Virone A, Ng WF, et al. Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sj gren’s Syndrome [J]. Arthritis Rheumatol, 2016, 68(4)∶977-985
[11] Rasmussen A, Ice JA, Li H, et al. Comparison of the American-European Consensus Group Sj gren’s syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort [J]. Ann Rheum Dis, 2014,73(1)∶31-38
[12] Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, et al. Treatment of primary Sj gren syndrome with rituximab: a randomized trial [J]. Ann Intern Med, 2014, 160(4)∶233-242
[13] Elise M,Gervais Kara A. Changs in the submandibular salivary gland epithelial cell subpopulations during progression of Sj gren’s syndrome-like disease in the NOD/Shiltj Mouse model [J]. Anat Rec,2015,298(9)∶1622-1634
[14] Yazisiz V, Behlul A, Basak ST. Expression of podoplanin in minor salivary glands increases in primary Sj gren’s syndrome [J]. J Rheumatol, 2013, 40(12)∶2100-2102

[1]	张源, 李新月. 脂多糖抑制牙周膜细胞骨唾液酸蛋白表达中微小RNA的筛选与验证[J]. 口腔医学研究, 2020, 36(5): 477-480.
[2]	邹会会, 徐文光, 尹西腾, 韩伟, 江琳琳. 基于SEER数据库分析影响大唾液腺腺样囊性癌患者预后的临床病理因素[J]. 口腔医学研究, 2020, 36(2): 167-171.
[3]	张曙光, 王玉龙, 徐文光, 尹西腾, 韩伟, 邹会会. 基于SEER数据库的唾液腺粘液表皮样癌预后因素分析[J]. 口腔医学研究, 2020, 36(10): 915-920.
[4]	连绮思, 吴红崑. 唾液在老年人群疾病诊疗中的研究进展[J]. 口腔医学研究, 2019, 35(3): 224-226.
[5]	侯雯, 苏达, 阙国鹰. 碳酸酐酶Ⅵ与4～5岁儿童龋病相关性的研究[J]. 口腔医学研究, 2018, 34(4): 363-366.
[6]	邹海啸, 杨海丽, 赵怡芳, 宋莉. 普萘洛尔对人黑色素瘤A375细胞增殖迁移和血管生成能力的影响及其机制研究[J]. 口腔医学研究, 2018, 34(2): 139-143.
[7]	李匡政,江义霞,范晓升,任倩,曹放云. CD147、MMP-9与VEGF在涎腺肿瘤组织中的表达及意义[J]. 口腔医学研究, 2018, 34(12): 1297-1301.
[8]	董子昱, 张芳. 口腔扁平苔藓唾液标记物研究现状分析[J]. 口腔医学研究, 2018, 34(11): 1168-1171.
[9]	刘鑫灿, 张德保, 刘仔龙. CD29的表达与人类唾液腺良恶性肿瘤发病关系的研究[J]. 口腔医学研究, 2018, 34(11): 1204-1207.
[10]	张孟钧, 栾庆先. 不同类型牙周炎患者唾液中8-OHdG含量的比较[J]. 口腔医学研究, 2017, 33(8): 898-900.
[11]	王辉, 库莉博, 徐国权, 赵志华, 马莉. 1H NMR代谢组学方法对牙周炎患者唾液代谢轮廓的分析[J]. 口腔医学研究, 2017, 33(4): 412-415.
[12]	苏红影, 李维善, 刘岩, 王欣荣, 张爽爽. 复发性阿弗他溃疡患者焦虑与唾液皮质醇和脱氢表雄酮水平的相关性研究[J]. 口腔医学研究, 2017, 33(2): 221-224.
[13]	王立鹤,薛龙,聂红兵,周海静,郭曼丽,康永杰,曾飒,杨兰. 益生性唾液乳酸杆菌的筛选及其抑菌物质的初步探究[J]. 口腔医学研究, 2016, 32(8): 819-822.
[14]	姜德奇,龚忠诚,林兆全,尹小朋,杜柏兴,王岳森. CT联合术中快速冰冻检查对唾液腺肿瘤病变的诊断价值分析[J]. 口腔医学研究, 2016, 32(8): 823-827.
[15]	俞洁,章功杰,陈松军,郑珉,李丽. 糖尿病患者唾液流率与口干相关性研究[J]. 口腔医学研究, 2016, 32(2): 177-180.

舍格伦综合征患者唾液MMP-9表达与组织病理分级相关性研究

Correlative Study on Expression of Saliva Matrix Metalloprotase 9 in Patients with Sjogren Syndrome and Histopathologic Grading.

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics