不同类型牙周炎患者唾液中8-OHdG含量的比较

doi:10.13701/j.cnki.kqyxyj.2017.08.024

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (8): 898-900.DOI: 10.13701/j.cnki.kqyxyj.2017.08.024

不同类型牙周炎患者唾液中8-OHdG含量的比较

张孟钧¹, 栾庆先^2*

1. 北京大学口腔医院门诊部牙周科北京 100034;
2. 北京大学口腔医院牙周科北京 100081

收稿日期:2017-01-16 出版日期:2017-08-20 发布日期:2017-08-28
通讯作者: 栾庆先,E-mail:kqluanqx@126.com
作者简介:张孟钧(1985~ ),女,河北人,住院医师,硕士,主要从事牙周病学临床治疗工作。

Comparison of 8-OHdG in Whole Unstimulated Saliva Obtained from Patients with Different Types of Periodontitis.

ZHANG Meng-jun, LUAN Qing-xian^*.

Department of Periodontics, Outpatient Department of Peking University School of Stomatology, Beijing 100034, China.

Received:2017-01-16 Online:2017-08-20 Published:2017-08-28

摘要/Abstract

摘要： 目的:检测不同类型牙周炎患者非刺激性全唾液中8-OHdG的含量并评价其与PD,CAL等临床指标的关系。方法:留取10名侵袭性牙周炎,10名慢性牙周炎和10名健康对照非刺激性全唾液,并记录全口PD,CAL,PLI,BI。ELLISA试剂盒检测唾液中8-OHdG含量。结果:8-OHdG含量在3组间存在统计学差异,AgP组:(3.8 ±1.0) μg/L, CP组:(2.37±0.7) μg/L,H组:(1.0±0.6) μg/L。PD,BI,PLI,CAL与8-OHdG含量存在相关关系,慢性与侵袭组中8-OHdG含量与平均CAL, CAL>5mm位点所占百分比,CAL>7 mm位点所占百分比相关。结论:唾液中8-OHdG含量可以反映牙周组织的破坏程度并与牙周炎类型存在相关关系。

关键词: 8-OHdG, 唾液, 牙周炎

Abstract: Objective: To evaluate the content of 8-hydroxydeoxyguanosine (8-OHdG) in whole unstimulated saliva from patients with different types of periodontitis and the relationship between 8-OHdG and clinical parameters. Methods: Whole unstimulated saliva samples were collected from 10 healthy control subjects (H), 10 chronic periondontitis (CP) and 10 aggressive periodontitis (AgP) patients. To determine the clinical condition of each subject, the plaque index (PLI), sulcus bleeding index (BI), clinical attachment level (CAL), and probing depth (PD) were measured. The salivary 8-OHdG level was measured using ELISA method. Results: Higher salivary 8-OHdG level was found among three groups (P<0.05). The results showed that the 8-OHdG levels were in the rank of Agp group > CP group > H group. The 8-OHdG has a relationship with all clinical parameters. In the CP and AgP groups the 8-OHdG has a relationship with CAL. Conclusion: The level of 8-OHdG in salivary indicates the periodontal status and has a relationship with peridontitis type.

Key words: 8-OHdG , Salivary, Periodontitis

中图分类号:

R781.4

张孟钧, 栾庆先. 不同类型牙周炎患者唾液中8-OHdG含量的比较[J]. 口腔医学研究, 2017, 33(8): 898-900.

ZHANG Meng-jun, LUAN Qing-xian.. Comparison of 8-OHdG in Whole Unstimulated Saliva Obtained from Patients with Different Types of Periodontitis.[J]. Journal of Oral Science Research, 2017, 33(8): 898-900.

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不同类型牙周炎患者唾液中8-OHdG含量的比较

Comparison of 8-OHdG in Whole Unstimulated Saliva Obtained from Patients with Different Types of Periodontitis.

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