Shh蛋白与慢性牙周炎炎症程度的相关性研究

doi:10.13701/j.cnki.kqyxyj.2020.02.010

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (2): 131-134.DOI: 10.13701/j.cnki.kqyxyj.2020.02.010

Shh蛋白与慢性牙周炎炎症程度的相关性研究

杨磊, 郭留云^*, 程志芬, 李碧浩

郑州大学第一附属医院口腔科河南郑州 450052

收稿日期:2019-06-18 出版日期:2020-02-28 发布日期:2020-04-24
通讯作者: 郭留云,E-mail:glyun@163.com
作者简介:杨磊(1994~ ),男,河南人,硕士在读,研究方向:牙周病病因及临床研究
基金资助:
河南省高等学校重点科研项目(编号:19A320051)

Correlation between Shh Protein and Inflammatory Degree of Chronic Periodontitis

YANG Lei, GUO Liuyun^*, CHENG Zhifen, LI Bihao

Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China

Received:2019-06-18 Online:2020-02-28 Published:2020-04-24

摘要/Abstract

摘要： 目的:探讨Sonic Hedgehog(Shh)信号通路中Shh蛋白与慢性牙周炎炎症程度的相关性。方法:选择健康对照20例(健康对照组),轻度牙周炎患者20例(轻度牙周炎组),中重度牙周炎患者20例(中重度牙周炎组),收集其龈沟液样本。采用ELISA法检测龈沟液中Shh蛋白、白细胞介素-6(IL-6)及白细胞介素-10(IL-10)的水平。结果:Shh蛋白、IL-6在慢性牙周炎组的水平均高于健康对照组(P＜0.05),且中重度慢性牙周炎组高于轻度慢性牙周炎组(P＜0.05);IL-10在轻度慢性牙周炎组的水平高于健康对照组及中重度慢性牙周炎组(P＜0.05),且健康对照组高于中重度慢性牙周炎组(P＜0.05);Shh蛋白、IL-6水平与出血指数(BI)、探诊深度(PD)均呈正相关(P＜0.05)。结论:Shh信号通路可能参与了慢性牙周炎的炎症反应过程。

关键词: 慢性牙周炎, 龈沟液, Shh蛋白, 白细胞介素-6, 白细胞介素-10

Abstract: Objective: To investigate the correlation between Sonic Hedgehog (Shh) protein and inflammatory degree of chronic periodontitis in Shh signaling pathway. Methods: The gingival crevicular fluid samples were collected from 20 healthy controls, 20 patients with mild periodontitis, and 20 patients with moderate to severe periodontitis. Gingival crevicular fluid level of Shh protein, IL-6, and IL-10 were measured by enzyme linked immunosorbent assay (ELISA). Results: The levels of Shh protein and IL-6 in gingival crevicular fluid were higher in chronic periodontitis group than those in healthy control group (P<0.05), and in moderate and severe chronic periodontitis group were higher than those in mild chronic periodontitis group (P<0.05). The level of IL-10 in mild chronic periodontitis group was higher than that in healthy control group and moderate-severe chronic periodontitis group (P<0.05), and that in healthy control group was higher than that in moderate-severe chronic periodontitis group (P<0.05). The levels of Shh protein and IL-6 were positively correlated with BI and PD (P<0.05). Conclusion: Ssh signaling pathway may be involved in the inflammatory response of chronic periodontitis.

Key words: chronic periodontitis, gingival crevicular fluid, Shh protein, IL-6, IL-10

杨磊, 郭留云, 程志芬, 李碧浩. Shh蛋白与慢性牙周炎炎症程度的相关性研究[J]. 口腔医学研究, 2020, 36(2): 131-134.

YANG Lei, GUO Liuyun, CHENG Zhifen, LI Bihao. Correlation between Shh Protein and Inflammatory Degree of Chronic Periodontitis[J]. Journal of Oral Science Research, 2020, 36(2): 131-134.

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Shh蛋白与慢性牙周炎炎症程度的相关性研究

Correlation between Shh Protein and Inflammatory Degree of Chronic Periodontitis

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