口腔医学研究

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (9): 854-857.DOI: 10.13701/j.cnki.kqyxyj.2019.09.009

• 牙周病学研究 • 上一篇    下一篇

2型糖尿病患者慢性牙周炎和种植体周围炎的炎症基因表达

吴鹏, 高承志*   

  1. 北京大学人民医院口腔科 北京 100044
  • 收稿日期:2019-04-09 出版日期:2019-09-28 发布日期:2019-09-25
  • 通讯作者: 高承志,E-mail:1318641216@qq.com
  • 作者简介:吴鹏(1981~ ),男,北京人,硕士,主治医师,研究方向:口腔种植修复。
  • 基金资助:
    北京市自然科学基金(编号:7182172)

Inflammatory Gene Expression in Chronic Periodontitis and Peri-implantitis in Patients with Type 2 Diabetes

WU Peng, GAO Chengzhi*   

  1. Department of Stomatology, Peking University People's Hospital, Beijing 100044, China
  • Received:2019-04-09 Online:2019-09-28 Published:2019-09-25

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摘要： 目的:2型糖尿病(diabetes mellitus,DM)患者代谢变化对炎症因子的影响及其在慢性牙周炎(chronic periodontitis,CP)和种植体周围炎(peri-implantitis,P-IM)的基因表达。方法:选择2016年6月~2018年12月我院口腔种植科治疗的143例牙周病患者作为研究对象,并选择同期牙周健康者24例作为对照组。比较牙周病暴露因素、临床指标、牙周及种植体周围肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)等炎症因子mRNA的表达及各炎症因子的相关性分析。结果:与对照组比较,年龄大、空腹血糖水平高、糖化血红蛋白(glycosylated hemoglobin,HbA1c)水平高及有吸烟史为CP及P-IM疾病暴露因素;牙周病患者菌斑指数(plaque index,PLI)、牙龈指数(gingival index,GI)、探诊出血(bleeding on probing,BOP)指数、探诊深度(probing depth,PD)、附着丧失(attachment loss,AL)及牙槽骨丧失(bone loss,BL)百分比均高于对照组;血糖控制不良患者GI、PD、AL及BL均明显高于血糖控制良好患者;合并DM患者中TNF-α在P-IM患者中表达更明显, IL-6及IL-8在CP患者中表达更明显;TNF-α、IL-6及IL-8在血糖控制不良患者中处于高表达状态;TNF-α、IL-6及IL-8与PLI、GI、BOP、PD、AL及BL呈正相关(P＜0.05)。结论:不合并DM患者中,P-IM中炎症反应较CP严重;合并DM患者可通过影响体内炎症因子的表达,加重CP及P-IM疾病的进展,且DM患者体内高血糖状态对GI、PD、AL及BL影响较大,治疗上应积极控制血糖。

关键词: 2型糖尿病, 慢性牙周炎, 种植体周围炎, 基因表达

Abstract: Objective: To investigate the effects of metabolic changes on inflammatory factors and monocyte chemotactic in patients with type 2 diabetes mellitus (DM), as well as to study their gene expression levels in chronic periodontitis (CP) and peri-implantitis (P-IM). Methods: 143 patients with periodontal disease and 24 healthy individuals (control group) in our hospital from June 2016 to December 2018 were selected. The disease exposure factors were compared. The clinical indicators of different types of patients were compared. The mRNA expression levels of inflammatory factors such as tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8) in the periodontal and implants were detected. The correlation of inflammatory factors among different patients was determined. Results: The age, high fasting blood glucose, high glycosylated hemoglobin (HbA1c) level, and smoking history were risk factors for CP and P-IM diseases. The percentage of plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), attachment loss (AL), and bone loss (BL) in patients with periodontal disease were higher than those in control group. GI, PD, AL, and BL in patients with poor blood sugar control were significantly higher than those in patients with good blood sugar control. Among patients with DM, the expression of TNF-α was more obvious in patients with P-IM, and the expression of IL-6 and IL-8 was more obvious in patients with CP. TNF-α, IL-6, and IL-8 were highly expressed in patients with poor blood sugar control. TNF-α, IL-6, and IL-8 were positively correlated with the severity of CP and P-IM diseases among patients with poor blood sugar control (P<0.05). Conclusion: Among DM free patients, inflammatory response in P-IM is more serious than that in CP, while DM can aggravate the progression of CP and P-IM diseases by affecting the expression of inflammatory factors in vivo.In addition, the hyperglycemia status in DM patients has a greater impact on GI, PD, AL, and BL.

Key words: diabetes mellitus, chronic periodontitis, peri-implantitis, Gene expression