口腔医学研究

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (7): 647-650.DOI: 10.13701/j.cnki.kqyxyj.2019.07.008

• 牙周病学研究 • 上一篇    下一篇

复方米诺环素奥硝唑温敏凝胶治疗慢性牙周炎的效果评价

王莉1, 杨晓艳2*   

  1. 1. 武汉科技大学附属天佑医院口腔科 湖北 武汉 430064;
    2. 武汉科技大学附属天佑医院药剂科 湖北 武汉 430064
  • 收稿日期:2018-11-20 出版日期:2019-07-25 发布日期:2019-07-24
  • 通讯作者: 杨晓艳,E-mail:321973499@qq.com
  • 作者简介:王莉(1976~ ),女,河南人,硕士,主治医师,研究方向:口腔医学

Evaluation on Efficacy of Thermosensitive Minocycline and Omidazole Complex Gel in Treatment of Chronic Periodontitis

WANG Li1, YANG Xiaoyan2*   

  1. 1. Department of Stomatology, Affiliated Tianyou Hospital of Wuhan University of Science and Technology, Wuhan 430064, China;
    2. Department of Pharmacy, Affiliated Tianyou Hospital of Wuhan University of Science and Technology, Wuhan 430064, China.
  • Received:2018-11-20 Online:2019-07-25 Published:2019-07-24

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摘要： 目的:评价复方米诺环素奥硝唑温敏凝胶治疗慢性牙周炎的临床效果。方法:选择慢性牙周炎患者132例,随机分为观察组和对照组,治疗组口腔局部使用复方米诺环素奥硝唑温敏凝胶;对照组局部使用米诺环素软膏,比较两组患者治疗效果、牙周炎指数变化情况、炎症因子水平和药物不良反应情况。结果:观察组总有效率为95.45%,对照组总有效率为83.33%,观察组牙周炎指数变化情况、炎症因子水平和药物不良反应均低于对照组,两两相比具有明显差异(P＜0.05)。结论:比较对慢性牙周炎患者局部应用复方米诺环素奥硝唑温敏凝胶和米诺环素的治疗效果后发现,复方米诺环素奥硝唑温敏凝胶可有效改善患者临床症状,值得临床推广

关键词: 慢性牙周炎, 米诺环素, 奥硝唑, 效果评价

Abstract: Objective: To evaluate the clinical effect of thermosensitive minocycline and omidazole complex gel on chronic periodontitis. Methods: A total of 132 patients with chronic periodontitis were recruited in this prospective study and were randomly divided into observation group (n=66) and control group (n=66). Patients in control group were given minocycline ointment and patients in observation group were given thermosensitive minocycline and omidazole complex gel. The therapeutic effect, changes of periodontitis index, inflammatory factor level, and adverse reaction in two groups were compared. Results: The total effective rates were 95.45% and 83.33% in observation and control groups, respectively; the changes of periodontitis index, inflammatory factor level, and adverse reaction in the observation group were lower than those in the control group (P＜0.05). Conclusion: The local application of thermosensitive minocycline and omidazole complex gel can effectively improve the clinical symptoms of patients with chronic periodontitis.

Key words: chronic periodontitis, minocycline, omidazole , efficacy evaluation