慢性牙周炎与阿尔茨海默病相关性的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.05.002

摘要/Abstract

摘要： 慢性牙周炎是由菌斑微生物始发,宿主免疫炎症反应及其他多种因素共同导致的牙齿支持组织破坏性疾病,其发生发展与全身系统性疾病密切相关。而阿尔茨海默病是较常见的进行性神经认知障碍。近年来研究发现,慢性牙周炎与阿尔茨海默病具有双向相关关系。本文就慢性牙周炎与阿尔茨海默病的相关性及其如何参与并促进阿尔茨海默病进展做一综述。

关键词: 慢性牙周炎, 阿尔茨海默病, 牙龈卟啉单胞菌, 促炎因子, β-淀粉样蛋白

Abstract: Chronic periodontitis is a destructive disease of dental support tissues which originated by dental plaque and generated by host immune-inflammatory responses and other factors. Its occurrence and development are closely associated with general systemic disease. Alzheimer's disease is one of the most common progressive neurocognitive disorder diseases. Recently, studies have found that chronic periodontitis is mutually associated with Alzheimer's disease. In this review, we conclude the correlation between chronic periodontitis and Alzheimer's disease, and summarize the mechanisms how chronic periodontitis participates in and promotes the progression of Alzheimer's disease.

Key words: Chronic periodontitis, Alzheimer’s disease, Porphyromonas gingivalis, Proinflammatory cytokine, Amyloid β-protein

聂然, 周延民. 慢性牙周炎与阿尔茨海默病相关性的研究进展[J]. 口腔医学研究, 2019, 35(5): 419-422.

NIE Ran, ZHOU Yan-min. Research Progress on Relationship between Chronic Periodontitis and Alzheimer’s Disease.[J]. Journal of Oral Science Research, 2019, 35(5): 419-422.

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