牙龈卟啉单胞菌抵抗固有免疫防御的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.02.002

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (2): 113-115.DOI: 10.13701/j.cnki.kqyxyj.2019.02.002

牙龈卟啉单胞菌抵抗固有免疫防御的研究进展

李雨阳,孟维艳^*

吉林大学口腔医院种植科吉林省牙发育及颌骨重塑与再生重点实验室吉林长春 130021

收稿日期:2018-02-10 出版日期:2019-02-18 发布日期:2019-02-25
通讯作者: 孟维艳,E-mail:mengsitong66@163.com
作者简介:李雨阳(1994~ ),男,江苏人,硕士在读,研究方向:口腔种植学。
基金资助:
国家自然科学基金(编号:81571007)

Research Progress of Porphyromonas Gingivalis Escaping from Defense of Innate Immune System.

LI Yu-yang, MENG Wei-yan

Department of Implant Center, Hospital of Stomatology, Jilin University, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China.

Received:2018-02-10 Online:2019-02-18 Published:2019-02-25

摘要/Abstract

摘要： 牙龈卟啉单胞菌是牙周炎的主要致病菌,其菌体结构和毒力因子可以对牙周组织造成严重的破坏。研究发现,牙龈卟啉单胞菌能逃避固有免疫系统的防御,突破黏膜屏障,抵抗吞噬细胞吞噬作用,破坏补体系统,在牙周炎的发生发展中起到了重要的作用。本文就牙龈卟啉单胞菌导致牙周炎的发生发展及其逃避固有免疫的机制进行综述。

关键词: 牙龈卟啉单胞菌, 固有免疫, 牙周炎, 毒力因子

Abstract: Porphyromonas gingivalis (P. gingivalis) is one of the major pathogenic bacterium in periodontitis and its structure and virulence factors play key roles in destroying periodontal tissues. Researchers found that it could escape from the defense of the innate immune system by breaking through mucosal barriers, resisting phagocytosis, and destroying complement systems, resulting in periodontitis. The article reviewed P.gingivalis about its leading to the development of periodontitis and the mechanism for escaping from the defense of the innate immune system.

Key words: Porphyromonas gingivalis, Innate immune, Periodontitis, Virulence factors

李雨阳,孟维艳. 牙龈卟啉单胞菌抵抗固有免疫防御的研究进展[J]. 口腔医学研究, 2019, 35(2): 113-115.

LI Yu-yang, MENG Wei-yan.. Research Progress of Porphyromonas Gingivalis Escaping from Defense of Innate Immune System.[J]. Journal of Oral Science Research, 2019, 35(2): 113-115.

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牙龈卟啉单胞菌抵抗固有免疫防御的研究进展

Research Progress of Porphyromonas Gingivalis Escaping from Defense of Innate Immune System.

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