口腔医学研究

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (2): 207-210.DOI: 10.13701/j.cnki.kqyxyj.2017.02.022

• 临床研究论著 • 上一篇    下一篇

Nrf2、HO-1在口腔鳞癌组织中的表达及其临床意义

贾宝超1, 关键1*, 戴辛鹏2, 杨键3, 王建杰4, 刘东璞5   

  1. 1. 佳木斯大学研究生部 黑龙江 佳木斯 154007;
    2. 佳木斯大学附属口腔医院 黑龙江 佳木斯 154004;
    3. 临安市人民医院 浙江 临安 311300;
    4.佳木斯大学基础医学院免疫教研室 黑龙江 佳木斯 154007;
    5. 佳木斯大学基础医学院病理教研室 黑龙江 佳木斯 大154007
  • 收稿日期:2016-08-14 出版日期:2017-02-20 发布日期:2017-02-22
  • 通讯作者: 关键,E-mail:guanjian1207@163.com
  • 作者简介:贾宝超(1991~ )男,黑龙江哈尔滨人,硕士在读,主要从事口腔颌面外科学研究。
  • 基金资助:
    佳木斯大学研究生科技创新项目(编号:LM2015_068)

Expression and Clinical Significance of Nrf2 and HO-1 in Oral Squamous Cell Carcinoma.

JIA Bao-chao1,GUAN Jian1*, DAI Xin-peng2, YANG Jian3, WANG Jian-jie4, LIU Dong-pu5   

  1. 1. Graduate Department, Jiamusi University, Jiamusi 154007, China;
    2. Department of Maxillofacial Surgery, Stomatological Hospital, Jiamusi University, Jiamusi 154004, China;
    3. People'
    s Hospital of Linan. Linan 311300, China;
    4. Department of Immunology, Basic Medical College, Jiamusi University, Jiamusi 154007, China;
    5. Department of Pathology, Basic Medical College, Jiamusi University, Jiamusi 154007, China.
  • Received:2016-08-14 Online:2017-02-20 Published:2017-02-22

摘要： 目的:探讨在口腔鳞癌(Oral squamous cell carcinomas,OSCC)的发生发展过程中核因子E2/ 相关因子 2(Nuclear related factor-E2-factor,Nrf2) 、HO-1(Heme oxygenase-1)可能存在的作用。方法:采用超敏免疫组化法Super Vision(SV)检测Nrf2、HO-1在23例癌旁正常组织和54例口腔鳞癌组织中的表达情况,并讨论两者表达是否具有相关性以及与口腔鳞癌患者的不同临床病理因素之间的关系。结果:在OSCC组织中Nrf2、HO-1的阳性表达率较癌旁正常组织高(P＜0.05);Nrf2、HO-1的阳性率与OSCC组织的性别,年龄,TNM分期,pT分期,部位,吸烟指数无明显相关性(P>0.05),Nrf2的阳性率与组织学分化程度,淋巴结转移不相关(P>0.05);HO-1的阳性率与组织学分化程度,淋巴结转移相关(P＜0.05); Nrf2、HO-1在OSCC组织中的阳性表达率呈正相关(r=0.295,P=0.032)。结论:Nrf2、HO-1对OSCC的发生发展有重要意义。

关键词: 口腔鳞癌(OSCC), Nrf2, HO-1, 免疫组化(IHC)

Abstract: Objective: To assess the potential significance of nuclear related factor-E2-factor and Heme oxygenase-1 in oral squamous cell carcinomas. Methods: Testing the expression of Nrf2 and HO-1 by immunohistochemistry,Super Vision,in 57 OSCC and 28 normal tissues,which without carcinoma cells,is to analysis the relationship between Nrf2 and HO-1 and to discuss the correlations between their expression and clinicopathological characteristics. Results: Result:Higher expression of Nrf2 and HO-1 was detected in OSCC than normal tissues(P＜0.05).Expression of Nrf2 and H0-1 was not related with age,gender,location,C-TNM,pT stage,smoking-index(P＞0.05).The expression of Nrf2 in OSCC was not related with differentiation and lymph node metastasis(P＞0.05).However,the expression of HO-1 was significantly correlated with differentiation and lymph node metastasis(P＜0.05).The expression of HO-1 was positively correlated with the expression of Nrf2 in OSCC(r=0.295,P=0.032). Conclusion: Present findings suggest that the expression of Nrf2 and HO-1 has significant role in the process of OSCC.

Key words: OSCC , Nrf2 , HO-1

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