口腔医学研究

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (5): 530-533.DOI: 10.13701/j.cnki.kqyxyj.2017.05.016

• 临床研究论著 • 上一篇    下一篇

利用潮汕人群第一前磨牙牙本质天冬氨酸消旋化比率推断生物学年龄的研究

陈仕生1*,姚小武1,于晓军2,王典2   

  1. 1. 汕头大学医学院第二附属医院口腔颌面外科 广东 汕头 515041;
    2. 汕头大学医学院法医学教研室 广东 汕头 515041
  • 收稿日期:2017-01-24 出版日期:2017-05-20 发布日期:2017-05-26
  • 通讯作者: 陈仕生,E-mail: drocean@126.com
  • 作者简介:陈仕生,男,广西玉林人,副主任医师,硕士,主要从事口腔颌面外科的临床治疗工作。
  • 基金资助:
    广东省医学科研基金(编号:A2016565)

Age Estimation of Chaoshan Population through Aspartic Acid Racemization in Dentin of First Premolar.

CHEN Shi-sheng1, YAO Xiao-wu1, YU Xiao-jun2, Wang Dian2.   

  1. 1. Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China; 2. Department of Forensic Medicine, Shantou University Medical College, Shantou 515041, China.
  • Received:2017-01-24 Online:2017-05-20 Published:2017-05-26

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摘要： 目的:探讨潮汕人群第一前磨牙牙本质天冬氨酸消旋化比率推断年龄的准确性。方法:收集潮汕人群第一前磨牙标本60例,利用高效液相色谱法检测其牙本质内天冬氨酸消旋化(D/L)比率,并与实际年龄建立回归方程;再用3例另外收集的牙本质标本检验方程的准确性。结果:潮汕人群第一前磨牙牙本质天冬氨酸消旋化(D/L)比率与年龄高度正相关(P<0.001),相关系数r=0.967,消旋化速率k=6.0×10-4/年,推断年龄误差SE=2.60岁。3例验证标本的误差分别是-0.3岁,+1.6岁,-2.2岁。结论:潮汕人群第一前磨牙牙本质天冬氨酸消旋化(D/L)比率可以准确推断年龄。

关键词: 第一前磨牙, 天冬氨酸消旋化比率, 推断年龄

Abstract: Objective: To analyze the relationship between chronological age and the D/L aspartic acid ratio in dentin of the first premolar of Chaoshan population. Methods: Sixty first premolar teeth from living individuals of known age were retrieved. Dentin was extracted from these teeth. The D- and L-aspartic acids in dentins were separated and detected by high performance liquid chromatography (HPLC) system. Linear regression was performed between the D/L aspartic acid ratio of dentins and chronological age. Dentin from another 3 cases was employed to test the accuracy of the regression equation. Results: Linear regression analysis showed a significant correlation between the first premolar dentin D/L aspartic acid ratio and chronological age (P<0.001), the correlation coefficient (r) was 0.967, SE=2.60 years; the racemization ratio k=6.0 ×10-4/ year. The errors of 3 cases were -0.3 years, +1.6 years and -2.2 years. Conclusion: Aspartic acid racemization in the first premolar dentin can be used as an accurate method to estimate chronological age in the Chaoshan population.

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