生物力学信号诱导骨髓间充质干细胞分化的现状

doi:10.13701/j.cnki.kqyxyj.2018.01.024

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (1): 94-96.DOI: 10.13701/j.cnki.kqyxyj.2018.01.024

生物力学信号诱导骨髓间充质干细胞分化的现状

孙凌璐¹, 苏雪莲^2,3, 何晓兰¹, 包广洁^2,3, 康宏^1*

1. 兰州大学口腔医学院研究所甘肃兰州 730000;
2. 西北民族大学甘肃省口腔疾病研究重点实验室甘肃兰州 730030;
3. 西北民族大学口腔医学国家民委重点实验室甘肃兰州 730030

收稿日期:2017-02-04 出版日期:2018-01-28 发布日期:2018-01-26
通讯作者: 康宏,E-mail:kanghong@lzu.edu.cn
作者简介:孙凌璐(1989~ ),女,青海省人,硕士,主要从事颞下颌关节盘组织工程研究。
基金资助:
国家自然基金(编号:81660189);中央高校重大培育项目(编号:31920150006)

Research Status and Perspectives of Biomechanical Signals for Differentiation of Bone Marrow Mesenchymal Stem Cells

SUN Ling-lu¹, SU Xue-lian^2,3, HE Xiao-lan¹, BAO Guang-jie^2,3, KANG Hong^1*

1. School of Stomatology, Lanzhou University, Lanzhou 730000,China;
2. Key Lab of Oral Disease of Gansu Province, Northwest University for Nationalities, Lanzhou 730000, China;
3. Key Lab of Stomatology of State Ethnic Affairs Commission, Northwest University for Nationalities, Lanzhou 730000, China.

Received:2017-02-04 Online:2018-01-28 Published:2018-01-26

摘要/Abstract

摘要： 骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)因多向分化潜能,被认为是组织工程种子细胞的重要来源,如何诱导其定向分化一直是组织工程的一大难题。生物力学信号可影响BMSCs分化,但应力加载种类、强度、频率、时间长短不同,BMSCs分化方向及分化程度不同,细胞在受力过程中,细胞-细胞外基质相互作用、细胞骨架、整合素信号通路、离子通道、黏附斑形成等均发生不同程度改建和变化,并影响BMSCs的力学信号传导。本文通过回顾体外加载不同的力学信号诱导BMSCs定向分化方式和途径、力学作用对BMSCs细胞骨架相关力学信号的转导以及相关特定蛋白基因表达的影响,对生物力学信号影响BMSCs分化的研究现状和未来趋势进行综述。

关键词: 生物力学信号, 分化, 骨髓间充质干细胞, 细胞骨架

Abstract: Because of multidirectional differentiating potentials, bone marrow mesenchymal stem cells (BMSCs) are considered as an important source of seed cells in tissue engineering. However, how to induce BMSCs into the target cells is challenging. Biomechanical signals can affect the differentiation of BMSCs by multiple ways such as loading types, intensity, frequency, and duration time of stress. The degree and directions of differentiation of MSCs are dependent on the interaction of BMSCs-extracellular matrix (ECM), cytoskeleton reorganization and reconstruction, integrin signal pathway and ion channels change, and focal adhesion formation in the process of cell transduction.

Key words: Biomechanical signals, Differentiation, Bone marrow mesenchymal stemells, Cytoskeleton

中图分类号:

R782.6

孙凌璐, 苏雪莲, 何晓兰, 包广洁, 康宏. 生物力学信号诱导骨髓间充质干细胞分化的现状[J]. 口腔医学研究, 2018, 34(1): 94-96.

SUN Ling-lu, SU Xue-lian, HE Xiao-lan, BAO Guang-jie, KANG Hong. Research Status and Perspectives of Biomechanical Signals for Differentiation of Bone Marrow Mesenchymal Stem Cells[J]. Journal of Oral Science Research, 2018, 34(1): 94-96.

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生物力学信号诱导骨髓间充质干细胞分化的现状

Research Status and Perspectives of Biomechanical Signals for Differentiation of Bone Marrow Mesenchymal Stem Cells

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