牙髓干细胞治疗神经系统疾病的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.10.004

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (10): 925-927.DOI: 10.13701/j.cnki.kqyxyj.2019.10.004

牙髓干细胞治疗神经系统疾病的研究进展

赵哲, 赵红宇^*

郑州大学第一附属医院口腔医学中心河南郑州 450000

收稿日期:2018-11-22 出版日期:2019-10-28 发布日期:2019-10-22
通讯作者: 赵红宇, E-mail:zhongyu93@163.com
作者简介:赵哲(1993~ ),女,河南叶县人,硕士在读,研究方向:牙周病学。
基金资助:
河南省高等学校重点科研项目计划 (编号:17A320012 )

Progress in the Treatment of Nervous System Diseases with Dental Pulp Stem Cells

ZHAO Zhe, ZHAO Hongyu^*

Department of Stomatology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.

Received:2018-11-22 Online:2019-10-28 Published:2019-10-22

摘要/Abstract

摘要： 牙髓干细胞是来源于神经嵴的间充质干细胞,具有自我更新和多向分化能力,在特定条件下可以分化为骨细胞、脂肪细胞、神经细胞等。牙髓干细胞分泌多种神经营养因子并表达神经标记物,许多研究已证实其在神经修复再生方面有巨大的潜力,本文就牙髓干细胞特性、成神经分化方案、中枢神经和周围神经损伤修复的研究进行综述。

关键词: 牙髓干细胞, 成神经分化, 神经损伤

Abstract: Dental pulp stem cells (DPSCs) are mesenchymal stem cells derived from neural crest. They have the biological characteristics of self-renewal ability and multi-lineage differentiation ability, and can differentiate into bone cells, adipose cells, and nerve cells under certain conditions. DPSCs secrete a variety of neurotrophic factors and express neurological markers. Many studies have confirmed that they have great potential in nerve repair and regeneration. In this paper, the characteristics of DPSCs, neurogenic differentiation, and repair of central nervous system and peripheral nerve system are reviewed.

Key words: dental pulp stem cells, neurogenic differentiation, nerve injury

赵哲, 赵红宇. 牙髓干细胞治疗神经系统疾病的研究进展[J]. 口腔医学研究, 2019, 35(10): 925-927.

ZHAO Zhe, ZHAO Hongyu. Progress in the Treatment of Nervous System Diseases with Dental Pulp Stem Cells[J]. Journal of Oral Science Research, 2019, 35(10): 925-927.

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牙髓干细胞治疗神经系统疾病的研究进展

Progress in the Treatment of Nervous System Diseases with Dental Pulp Stem Cells

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