微小RNA导致腭裂发生机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.12.002

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (12): 1111-1114.DOI: 10.13701/j.cnki.kqyxyj.2019.12.002

微小RNA导致腭裂发生机制的研究进展

郭佳男^1,2, 何苇^1*

1. 遵义医科大学贵州遵义 563000;
2. 遵义医科大学附属口腔医院口腔颌面外科贵州遵义 563000

收稿日期:2018-12-06 出版日期:2019-12-28 发布日期:2019-12-23
通讯作者: 何苇,E-mail:heweichenhui@163.com
作者简介:郭佳男(1990~ ),男,湖北黄石人,硕士在读,住院医师,主要从事口腔颌面外科基础及临床的研究工作。
基金资助:
国家自然科学基金(编号:81360165)贵州省研究生创新基地项目(合同号:黔科研合CXJD字[2014]005)

Research Progress on Mechanism of Cleft Palate Caused by MicroRNA

GUO Jianan^1,2, HE Wei^1*

1. Zunyi Medical University,Zunyi 563000,China;
2. Department of Oral & Maxillofacial Surgery,Hospital of Stomatology,Zunyi Medical University,Zunyi 563000,China.

Received:2018-12-06 Online:2019-12-28 Published:2019-12-23

摘要/Abstract

摘要： 微小RNA(microRNA,miRNA)是一类长度很短的非编码RNA,通过调控其靶基因的表达参与胚胎发育过程。但很长一段时间,学者们都将目光聚焦在编码蛋白质的mRNA上,近年来随着对非编码RNA(non-coding RNA,ncRNA),尤其是miRNA研究的深入,其在腭发育中的作用机制正在逐渐被阐明。因此本文将近年来针对miRNA导致腭裂发生机制的研究进展进行综述,以期为广大唇腭裂研究者提供新的参考和视角。

关键词: 微小RNA, 腭裂, 病因学, 发病机制

Abstract: MicroRNAs are a class of small non-coding RNAs that participate in the development of embryos by regulating the expression of their target genes. For a long time, scholars have focused on protein-coding mRNA. However, in recent years, with the in-depth study of non-coding RNAs, especially miRNAs, the mechanism of their role in palatal development is gradually elucidated. Therefore, this review summarizes the recent progress on the mechanism of cleft palate caused by miRNAs, hoping to provide a new reference and perspective for the cleft lip and palate researchers.

Key words: microRNA, cleft palate, etiology, pathogenesis

郭佳男, 何苇. 微小RNA导致腭裂发生机制的研究进展[J]. 口腔医学研究, 2019, 35(12): 1111-1114.

GUO Jianan, HE Wei. Research Progress on Mechanism of Cleft Palate Caused by MicroRNA[J]. Journal of Oral Science Research, 2019, 35(12): 1111-1114.

参考文献

[1] Setó-Salvia N, Stanier P. Genetics of cleft lip and/or cleft palate:association with other common anomalies [J]. Eur J Med Genet, 2014, 57(8): 381-393.
[2] Dixon MJ, Marazita ML, Beaty TH, et al. Cleft lip and palate:understanding genetic and environmental influences [J]. Nat Rev Genet, 2011, 12(3): 167-178.
[3] Bush JO, Jiang R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development [J]. Development, 2012, 139(2): 231-243.
[4] Li C, Lan Y, Jiang R. Molecular and cellular mechanisms of palate development [J]. J Dent Res, 2017, 96(11): 1184-1191.
[5] Simioni M, Araujo TK, Monlleo IL, et al. Investigation of genetic factors underlying typical orofacial clefts: mutational screening and copy number variation [J]. J Hum Genet, 2015, 60(1): 17-25.
[6] Schoen C, Aschrafi A, Thonissen M, et al. MicroRNAs in palatogenesis and cleft palate [J]. Front Physiol, 2017, 8: 165.
[7] 王鑫, 赵尔杨.腭裂相关MicroRNA与信号通路的相互作用[J].口腔医学研究, 2015, 31(5): 528-530.
[8] Carroll AP, Goodall GJ, Liu B. Understanding principles of miRNA target recognition and function through integrated biological and bioinformatics approaches [J]. Wiley Interdiscip Rev RNA, 2014, 5(3): 361-379.
[9] Mukhopadhyay P, Brock G, Pihur V, et al. Developmental microRNA expression profiling of murine embryonic orofacial tissue [J]. Birth Defects Res A Clin Mol Teratol, 2010, 88(7): 511-534.
[10] Warner DR, Mukhopadhyay P, Brock G, et al. MicroRNA expression profiling of the developing murine upper lip [J]. Dev Growth Differ, 2014, 56(6): 434-447.
[11] Ding HL, Hooper JE, Batzel P, et al. MicroRNA profiling during craniofacial development: potential roles for mir23b and mir133b [J]. Front Physiol, 2016, 7: 281.
[12] Seelan RS, Mukhopadhyay P, Warner DR, et al. Methylated microRNA genes of the developing murine palate [J]. Microrna, 2014, 3(3): 160-173.
[13] 苏艳国, 孟琰, 孙长生, 等. NSCL/P患儿异常表达miRNAs的生物信息学分析[J].实用口腔医学, 2016, 32(6): 805-809.
[14] Nie X, Wang Q, Jiao K.Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis [J]. Mech Dev, 2011, 128(3-4): 200-207.
[15] 魏安瑶, 赵鹏辉, 夏景兰, 等.MicroRNA-23a调控斑马鱼颅神经嵴细胞迁移和分化[J/CD].发育医学电子杂志, 2017,5(1): 7-13.
[16] Wang J, Bai Y, Li H, et al. MicroRNA-17-92, a direct Ap-2 transcriptional target, modulates T-box factor activity in orofacial clefting [J]. PLoS Genet, 2013, 9(9): e1003785.
[17] Li L, Shi JY, Zhu GQ, et al. MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFβ pathway in mouse palatal mesenchymal cells [J]. J Cell Biochem, 2012, 113(4): 1235-1244.
[18] 陈勇龙.miR-382在小鼠腭板发生过程中的作用机制研究[D].汕头大学, 2015.
[19] Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 [J]. Nat Cell Biol, 2008, 10(5): 593-601.
[20] Shin JO, Lee JM, Cho KW, et al. MiR-200b is involved in Tgf-b signaling to regulate mammalian palate development [J]. Histochem Cell Biol, 2012, 137(1): 67-78.
[21] Shin JO, Nakagawa E, Kim EJ, et al. miR-200b regulates cell migration via Zeb family during mouse palate development [J]. Histochem Cell Biol, 2012, 137(4): 459-470.
[22] 廖捍斯.miR-1/206靶向调控Pax7在维甲酸诱导的C2C12细胞肌向分化异常中的作用研究[D].大连医科大学,2016.
[23] Bangs F, Anderson KV. Primary cilia and mammalian hedgehog signaling [J]. Cold Spring Harb Perspect Biol, 2017, 9(5): 1-21.
[24] Hammond NL, Brookes KJ, Dixon MJ. Ectopic hedgehog signaling causes cleft palate and defective osteogenesis [J]. J Dent Res, 2018, 97(13): 1485-1493.
[25] Hudish LI, Galati DF, Ravanelli AM, et al. miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling [J]. Development, 2016, 143(13): 2292-2304.
[26] Mansini AP, Lorenzo Pisarello MJ, Thelen KM, et al. MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma [J]. Hepatology, 2018, 68(2): 561-573.
[27] 殷杰, 郭阁, 何苇, 等.小鼠胚胎腭间充质细胞的初级纤毛观察[J].武汉大学学报(医学版), 2018, 39(4): 587-590.
[28] Mathieu J, Ruohola-Baker H. Regulation of stem cell populations by microRNAs [J]. Adv Exp Med Biol, 2013, 786: 329-351.
[29] Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases [J]. Nat Rev Drug Discov, 2017, 16(3): 203-222.

微小RNA导致腭裂发生机制的研究进展

Research Progress on Mechanism of Cleft Palate Caused by MicroRNA

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