口腔微生物与消化系统癌症关系的研究进展

doi:10.13701/j.cnki.kqyxyj.2020.02.001

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (2): 93-97.DOI: 10.13701/j.cnki.kqyxyj.2020.02.001

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口腔微生物与消化系统癌症关系的研究进展

张志民^*, 程博群

吉林大学口腔医院牙体牙髓科吉林长春 130021

收稿日期:2019-05-15 出版日期:2020-02-28 发布日期:2020-04-24
作者简介:张志民,男,医学博士,教授,主任医师,博士研究生导师,吉林大学口腔医院党委书记。国际牙医师学院院士,中华口腔医学会理事,中华口腔医学会牙体牙髓专业委员会常委,吉林省口腔医学会副会长,吉林省口腔医学会牙体牙髓专业委员会主任委员,长春市医学会口腔专科委员会主任委员,《口腔医学研究》、《吉林大学学报(医学版)》等多个杂志编委,全国高等医药院校本科生统编教材《牙体牙髓病学》编委,吉林省卫生系统第二批有突出贡献中青年专业技术人才。

Research Progress on Relationship between Oral Microbes and Digestive System Cancer

ZHANG Zhimin^*, CHENG Boqun

Department of Endodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China

Received:2019-05-15 Online:2020-02-28 Published:2020-04-24

摘要/Abstract

摘要： 口腔微生物组在人类健康和疾病状态中发挥着重要作用。近年来癌症患者体内复杂的微生物群落特征,微生物和癌症之间的相互作用以及微生物参与癌症发生、预防和治疗的可能机制等引起了广泛关注。大量研究结果表明,微生物菌群失调通过多种途径导致癌症易感性。因此,本文主要通过回顾口腔微生物群对消化系统癌症(包括食管癌、胃癌、胰腺癌和结肠直肠癌)的影响,为口腔菌群与消化系统癌症关系的进一步研究以及口腔微生物与全身系统疾病的进一步探索提供参考。

关键词: 口腔微生物组, 消化系统癌症, 食管癌, 胃癌, 胰腺癌, 结直肠癌

Abstract: The human oral microbiota plays an important role in both human health and disease states. Over the past decade, the interaction between microbes and cancer has attracted much attention in understanding the various characteristics of complex microbial communities and the possible mechanisms by which microbiota participates in cancer prevention, carcinogenesis, and anticancer therapy. Numerous studies have shown that microbial disorders lead to cancer susceptibility through a variety of pathways. In this article, the effects of oral microbiota on digestive system cancers (including esophageal cancer, gastric cancer pancreatic cancer, and colorectal cancer) are reviewed to provide references for further research on the relationship between oral microbiota and digestive system cancers, as well as oral microbiota and systemic diseases and cancers.

Key words: oral microbiota, digestive system cancersConclusionesophageal cancerConclusiongastric cancerConclusionpancreatic cancerConclusioncolorectal cancer

张志民, 程博群. 口腔微生物与消化系统癌症关系的研究进展[J]. 口腔医学研究, 2020, 36(2): 93-97.

ZHANG Zhimin, CHENG Boqun. Research Progress on Relationship between Oral Microbes and Digestive System Cancer[J]. Journal of Oral Science Research, 2020, 36(2): 93-97.

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口腔微生物与消化系统癌症关系的研究进展

Research Progress on Relationship between Oral Microbes and Digestive System Cancer

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