口腔医学研究

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (5): 433-436.DOI: 10.13701/j.cnki.kqyxyj.2020.05.008

• 口腔肿瘤学研究 • 上一篇    下一篇

EpCAM 和β-catenin 在唾液腺黏液表皮样癌中的表达及意义

朱云娜1,2, 郑绘霞1, 肖虹1, 万惠丽1, 吕佳乐1,2, 梁钢1, 李宁1*   

  1. 1.山西医科大学第一医院病理科 山西 太原 030001;
    2.山西医科大学第一临床学院 山西 太原 030001
  • 收稿日期:2019-07-30 出版日期:2020-06-16 发布日期:2020-06-18
  • 通讯作者: * 李宁,E-mail:shanxiningning@126.com
  • 作者简介:朱云娜(1995~ ),女,山西临汾人,硕士在读,住院医师,研究方向:肿瘤分子病理。

Expression and Significance of EpCAM and β-catenin in Mucoepidermoid Carcinoma of Salivary Glands

ZHU Yunna1,2, ZHENG Huixia1, XIAO Hong1, WAN Huili1, LV Jiale1,2, LIANG Gang1, LI Ning1*   

  1. 1. Department of Pathology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China;
    2. First Clinical College, Shanxi Medical University, Taiyuan 030001, China
  • Received:2019-07-30 Online:2020-06-16 Published:2020-06-18

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摘要： 目的:探讨唾液腺黏液表皮样癌(mucoepidermoid carcinoma,MEC)中EpCAM 和β-catenin蛋白表达与临床病理意义。方法:免疫组化Envision法检测57例MEC和20例正常唾液腺组织中EpCAM和β-catenin的表达。结果:(1)EpCAM、β-catenin的阳性率在MEC明显高于正常组织(P=0.002,P=0.001);EpCAM在高、中、低分化MEC中阳性率分别为36.36%、61.11%、82.35%,差异有统计学意义(P=0.015),β-catenin的阳性率分别为45.45%、72.22%、88.24%,差异有统计学意义(P=0.016);(2)EpCAM表达与淋巴结转移情况相关(P=0.024),EpCAM和β-catenin表达均与患者年龄相关(P=0.004,P=0.004),与患者性别、肿物发生的部位等均无关;(3)EpCAM和β-catenin 在MEC中的表达呈正相关(R=0.48,P＜0.001)。结论:EpCAM和β-catenin表达与MEC恶性程度相关,联合检测二者有助于MEC的分级、辅助预测预后,并为MEC的靶向治疗提供依据。

关键词: 黏液表皮样癌, EpCAM, β-catenin

Abstract: Objective: To investigate the expression and clinicopathologic significance of EpCAM and β-catenin in mucoepidermoid carcinoma (MEC). Methods: The expressions of EpCAM and β-catenin in 57 cases of MEC and 20 cases of normal salivary gland tissues were detected by immunohistochemical staining (Envision method). Results: The positive expression rate of EpCAM and β-catenin in MEC was significantly higher than that in normal tissues (P=0.002, P=0.001). The positive expression rates of EpCAM in MEC with high, medium, and low differentiation were 36.36%, 61.11%, and 82.35%, respectively (P=0.015), and the positive expression rates of β-catenin were 45.45%, 72.22%, and 88.24%, respectively, with statistically significant differences (P=0.016). Both EpCAM and β-catenin expression were correlated with patient age (P=0.004, P=0.004). EpCAM was correlated with lymph node metastasis (P=0.024), and the expression of EpCAM and β-catenin was unrelated to the gender of patients and the location of tumor. The expression of EpCAM and β-catenin in MEC was positively correlated (R=0.48, P < 0.001). Conclusion: Expressions of EpCAM and β-catenin were associated with MEC malignancies. Joint tests could help to evaluate MEC, assist in predicting prognosis, and provide basis for the targeted treatment of MEC.

Key words: mucoepidermoid carcinoma, EpCAM, β-catenin