糖尿病与根尖周炎相关关系研究进展

doi:10.13701/j.cnki.kqyxyj.2024.04.001

摘要/Abstract

摘要： 糖尿病是以高血糖为特征的慢性代谢性疾病。根尖周炎是一种以牙周组织破坏为特征的感染性疾病,是根管系统微生物群、微生物毒性因子和宿主免疫应答之间复杂相互作用的结果。糖尿病和根尖周炎是两种生物学相关的疾病,糖尿病和根尖周炎的双向关系一直是研究的重点。本文综述了糖尿病和根尖周炎两种疾病近年来在根管治疗效果、血糖水平、炎症反应等因素之间存在的关联。深入了解糖尿病与根尖周炎之间的关系对阐明其双向机制具有重要意义,将为临床更好更准确治疗糖尿病伴根尖周炎患者产生积极影响。

关键词: 糖尿病, 根尖周炎, 根管治疗, 血糖水平

Abstract: Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia. Apical inflammation is an infectious disease characterized by the destruction of periodontal tissue. It is the result of complex interaction between microbiota, microbial virulence factors, and host immune response in the root canal system. Diabetes mellitus and apical inflammation are two biologically related diseases. The bidirectional relationship between diabetes and apical inflammation has been the focus of in-depth research. This article reviews the relationship between effects of root canal treatment, blood glucose level, and inflammatory response of diabetes mellitus and apical inflammation in recent years. A thorough understanding of the relationship between diabetes and apical inflammation is of great significance to elucidate the bidirectional mechanism, and will have a positive impact on better and more accurate treatment of diabetes patients with apical inflammation.

Key words: diabetes mellitus, apical inflammation, root canal treatment, blood glucose level

刘月华, 田宇. 糖尿病与根尖周炎相关关系研究进展[J]. 口腔医学研究, 2024, 40(4): 283-286.

LIU Yuehua, TIAN Yu. Research Progress on Relationship between Diabetes Mellitus and Apical Periodontitis[J]. Journal of Oral Science Research, 2024, 40(4): 283-286.

参考文献

[1] Portes J, Bullón B, Quiles JL, et al. Diabetes mellitus and periodontitis share intracellular disorders as the main meeting point [J]. Cells, 2021, 10(9):2411.
[2] Pan S, Hu B, Sun J, et al. Identification of cross-talk pathways and ferroptosis-related genes in periodontitis and type 2 diabetes mellitus by bioinformatics analysis and experimental validation [J]. Front Immunol, 2022, 13:1015491.
[3] Gu M, Wang P, Xiang S, et al. Effects of type 2 diabetes and metformin on salivary microbiota in patients with chronic periodontitis [J]. Microb Pathog, 2021, 161(Pt B):105277.
[4] Bian Y, Liu C, Fu Z. Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes [J]. Head Face Med, 2021, 17(1):12.
[5] De la Torre-Luna R, Domínguez-Pérez RA, Guillén-Nepita AL, et al. Prevalence of Candida albicans in primary endodontic infections associated with a higher frequency of apical periodontitis in type two diabetes mellitus patients [J]. Eur J Clin Microbiol Infect Dis, 2020, 39(1):131-138.
[6] 崔晓宁.血糖控制方法对根管治疗应用效果影响分析[J].糖尿病新世界,2021,24(18):57-60.
[7] Tang B, Yan C, Shen X, et al. The bidirectional biological interplay between microbiome and viruses in periodontitis and type-2 diabetes mellitus [J]. Front Immunol, 2022, 13:885029.
[8] Vázquez-Ramos VR, Pérez-Serrano RM, García-Solís P, et al. Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients [J]. J Appl Oral Sci, 2023, 30:e20220362.
[9] Mathew JE, Jacob JJ, Kalra S. Periodontitis management in diabetes care [J]. J Pak Med Assoc, 2021, 71(8):2097-2099.
[10] Budreikait K, Varoneckait M, Oleinikait D, et al. Association between apical periodontitis and root canal treatment in patients with type Ⅱ diabetes. A systematic review [J]. Stomatologija, 2022, 24(4):100-103.
[11] Niazi SA, Bakhsh A. Association between endodontic infection, its treatment and systemic health: A narrative review [J]. Medicina (Kaunas), 2022, 58(7):931.
[12] 史艳霞,孟晓慧,李亮,等.光动力疗法对伴糖尿病根尖周炎患者的根管治疗效果[J].口腔材料器械杂志,2023,32(1):69-72.
[13] Juncar RI, Precup AI, Juncar M. Odontogenic inflammatory lesions in patients with type 2 diabetes mellitus: A prospective study of 128 cases [J]. Niger J Clin Pract, 2020, 23(3):298-303.
[14] Claudino M, Nunes IS, Gennaro G, et al. Diabetes triggers the loss of tooth structure associated to radiographical and histological dental changes and its evolution to progressive pulp and periapical lesions in rats [J]. Arch Oral Biol, 2015, 60(11):1690-1698.
[15] 衣晓伟,黄定明,张岚.糖尿病患者牙髓根尖周病的发病机制及临床管理[J].国际口腔医学杂志,2018,45(2):214-218.
[16] Wang H, Chang X, Ma Q, et al. Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration [J]. Bioact Mater, 2022, 21:324-339.
[17] Loureiro C, Buzalaf MAR, Pessan JP, et al. Proteomic analysis of infected root canals with apical periodontitis in patients with type 2 diabetes mellitus: A cross-sectional study [J]. Int Endod J, 2022, 55(9):910-922.
[18] Gupta A, Aggarwal V, Mehta N, et al. Diabetes mellitus and the healing of periapical lesions in root filled teeth: a systematic review and meta-analysis [J]. Int Endod J, 2020, 53(11):1472-1484.
[19] 吴欣星,鲁娟,穆晓娟.糖尿病与非糖尿病孕妇根尖周炎根管治疗效果分析[J].中国妇幼保健,2020,35(24):4729-4732.
[20] 匡蕾.根尖周炎伴糖尿病患者根管治疗的效果分析与研究[J].糖尿病新世界,2020,23(14):23-25.
[21] Martinho JP, Coelho A, Oliveiros B, et al. Impairment of the angiogenic process may contribute to lower success rate of root canal treatments in diabetes mellitus [J]. Int Endod J, 2021, 54(10):1687-1698.
[22] Segura-Egea JJ, Cabanillas-Balsera D, Jiménez-Sénchez MC, et al. Endodontics and diabetes: association versus causation [J]. Int Endod J, 2019, 52(6):790-802.
[23] Yip N, Liu C, Wu D, et al. The association of apical periodontitis and type 2 diabetes mellitus: A large hospital network cross-sectional case-controlled study [J]. J Am Dent Assoc, 2021, 152(6):434-443.
[24] Sarmento EB, Gomes CC, Pires FR, et al. Immunoexpression of bone resorption biomarkers in apical periodontitis in diabetics and normoglycaemics [J]. Int Endod J, 2020, 53(8):1025-1032.
[25] Angst PDM, Finger Stadler A, Mendez M, et al. Supportive periodontal therapy in moderate-to-severe periodontitis patients: A two-year randomized clinical trial [J]. J Clin Periodontol, 2019, 46(11):1083-1093.
[26] Stys LPA, Böttcher DE, Scarparo RK, et al. Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings [J]. Aust Endod J, 2022, 48(1):105-115.
[27] 黎炽炎.根管治疗术对老年糖尿病患者根尖周炎的临床疗效分析[J].中国卫生标准管理,2022,13(22):96-100.
[28] Sisli SN. Evaluation of the relationship between type Ⅱ diabetes mellitus and the prevalence of apical periodontitis in root-filled teeth using cone beam computed tomography: An observational cross-sectional study [J]. Med Princ Pract, 2019, 28(6):533-538.
[29] Luong A, Tawfik AN, Islamoglu H, et al. Periodontitis and diabetes mellitus co-morbidity: A molecular dialogue [J]. J Oral Biosci, 2021, 63(4):360-369.
[30] Romano F, Perotto S, Mohamed SEO, et al. Type 2 diabetes mellitus and periodontitis: Are diabetic patients aware about this bidirectional association? [J]. Acta Diabetol, 2021, 58(9):1277-1280.
[31] Saleh W, Xue W, Katz J. Diabetes mellitus and periapical abscess: A cross-sectional study [J]. J Endod, 2020, 46(11):1605-1609.
[32] 孙熹,张旗.巨噬细胞极化在糖尿病合并根尖周炎中作用的研究[J].口腔医学研究,2021,37(5):412-417.
[33] 张木强, 糖尿病伴发牙周炎患者牙周病变程度与血糖水平的关系研究[J].中国实用医药,2020,15(18):97-98.
[34] Limeira FIR, Arantes DC, de Souza Oliveira C, et al. Root canal treatment and apical periodontitis in a Brazilian population with type 1 diabetes mellitus: A cross-sectional paired study [J]. J Endod, 2020, 46(6):756-762.