口腔医学研究

口腔医学研究 ›› 2024, Vol. 40 ›› Issue (9): 843-846.DOI: 10.13701/j.cnki.kqyxyj.2024.09.017

• 研究生病例精粹——口腔黏膜病系列(9) • 上一篇    

以黏膜皮肤色素沉着为首发表现的艾迪生病1例

陈潇婕, 卢锐, 周刚*   

  1. 口颌系统重建与再生全国重点实验室,口腔生物医学教育部重点实验室, 口腔医学湖北省重点实验室,武汉大学口腔医院口腔黏膜科 湖北 武汉 430079
  • 收稿日期:2024-08-23 出版日期:2024-09-28 发布日期:2024-09-25
  • 通讯作者: *周刚,E-mail:zhougang@whu.edu.cn
  • 作者简介:陈潇婕(1990~),女,湖北宜昌人,博士,主治医师,研究方向:口腔黏膜病学。

A Case of Addison's Disease with Mucosal Skin Pigmentation as Initial Manifestation

CHEN Xiaojie, LU Rui, ZHOU Gang*   

  1. State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  • Received:2024-08-23 Online:2024-09-28 Published:2024-09-25

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摘要： 原发性肾上腺皮质功能减退症,又称艾迪生病,是一种罕见的、与自身免疫密切相关的肾上腺疾病,可伴发黏膜皮肤色素沉着等各类全身表现,甚至发生肾上腺危象而危及生命。口腔黏膜色素沉着常早于皮肤出现,易与其他色素沉着类疾病相混淆,在临床中易被误诊。本文报道了1例以黏膜皮肤色素沉着为首发表现的艾迪生病,及时诊治后口腔黏膜和皮肤色素沉着完全消失,为该病提供了具有口腔黏膜专科特色的诊疗思路。

关键词: 艾迪生病, 原发性肾上腺皮质功能减退症, 色素沉着

Abstract: Primary adrenal insufficiency, also known as Addison's disease, is a rare adrenal diseases closely related to autoimmune diseases that can be accompanied by various systemic manifestations, including mucosal and skin pigmentation, and even lead to adrenal crisis that endangers life. Pigmentation of oral mucosa often appears earlier than on the skin, which may be confused with other pigmentation related diseases and easily misdiagnosed in clinical practice. This article reports a case of Addison's disease with mucosal and skin pigmentation as the initial symptom. After timely diagnosis and treatment, the pigmentation completely disappeared, providing a specialty diagnosis and treatment approach with oral mucosal characteristics for this disease.

Key words: Addison’s disease, Primary adrenal insufficiency, pigmentation