天然药物治疗口腔黏膜下纤维性变的研究进展

doi:10.13701/j.cnki.kqyxyj.2026.02.001

摘要/Abstract

摘要： 口腔黏膜下纤维性变(oral submucous fibrosis,OSF)是一种慢性口腔黏膜疾病,目前缺乏有效的治疗手段。本文回顾了天然药物治疗OSF的研究进展,包括姜黄素、丹参酮、黄连素、黄芩苷、芦荟和甘草等。这些药物通过抗炎、抗氧化、抗纤维化等多种机制,影响OSF的发生发展。且部分研究聚焦于中西药联合应用,取得了较好成效。然而,目前研究多处于实验阶段,存在机制未完全阐明、临床应用安全性和有效性有待验证等局限性。未来应加强临床研究,探索最佳用药方案,寻找更有效的天然药物。

关键词: 口腔黏膜下纤维化, 治疗, 中医药, 丹参

Abstract: Oral submucous fibrosis (OSF) is a chronic oral mucosal disease, and there is currently a lack of specific treatment methods. This article reviews the research progress of natural compounds in the treatment of OSF, including curcumin, tanshinone, berberine, baicalin, aloe vera, and licorice. These drugs target the development and progression of OSF through various mechanisms such as anti-inflammatory, antioxidant, and antifibrotic effects. Moreover, some studies have focused on the combined application of Chinese and Western medicine and have achieved good results. However, most of the current studies are in the experimental stage, and there are limitations such as incomplete elucidation of the mechanism and the need to verify the safety and effectiveness of clinical applications. Future research should strengthen clinical studies, explore the optimal medication regimen, and search for more effective natural compounds.

Key words: oral submucous fibrosis, treatment, Chinese medicine, salvia miltiorrhiza

唐湘哲, 邓智元. 天然药物治疗口腔黏膜下纤维性变的研究进展[J]. 口腔医学研究, 2026, 42(2): 89-92.

TANG Xiangzhe, DENG Zhiyuan. Research Progress in Treatment of Oral Submucous Fibrosis with Natural Compounds[J]. Journal of Oral Science Research, 2026, 42(2): 89-92.

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