重组人骨形态发生蛋白-2与去蛋白牛骨基质在上颌窦底外提升中联合应用研究

doi:10.13701/j.cnki.kqyxyj.2026.03.007

摘要/Abstract

摘要： 目的:探究重组人骨形态发生蛋白-2(recombinant bone morphogenetic proteinrh-2,rhBMP-2)、去蛋白牛骨基质(deproteinized bovine bone mineral, DBBM)联合应用于上颌窦底外提升术(external sinus floor elevation,ESFE)的临床效果。方法:2019年2月~2023年9月间将符合条件的34例患者随机分组,A组使用DBBM,B组使用rhBMP-2+DBBM进行ESFE。于ESFE后6个月进行种植手术,种植术中钻取种植窝骨柱进行后续微计算机断层扫描(micro-computed tomography,micro-CT)及组织学分析。种植术后3个月、6个月复查记录种植体稳定系数(implant stability quotient,ISQ)。结果:Micro-CT分析结果显示两组间骨体积/组织体积及材料体积/组织体积差异有统计学意义(P＜0.05);骨组织切片分析结果显示两组间新生骨占比差异有统计学意义(P＜0.05);两组间种植后3个月时ISQ差异有统计学意义(P＜0.05)。结论:ESFE术中联合应用rhBMP-2与DBBM较单独应用DBBM更有利于新生骨的形成,可为后续种植手术的开展创造更有利的骨条件。

关键词: 上颌窦底外提升, 重组人骨形态发生蛋白-2, 去蛋白牛骨基质, 口腔种植

Abstract: Objective: To evaluate the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with deproteinized bovine bone mineral (DBBM) used in external sinus floor elevation (ESFE). Methods: From February 2019 to September 2023, 34 eligible patients were randomly divided into group A using DBBM in ESFE, group B using rhBMP-2+DBBM in ESFE. Implant surgeries were performed at 6 months after ESFE. Bone blocks in implant osteotomy sites were harvested for subsequent micro-computed tomography (micro-CT) scans and histological analysis. Implant stability quotients (ISQ) were recorded at 3 and 6 months after implant surgeries. Results: Micro-CT analysis showed statistically significant differences in bone volume/tissue volume and material volume/tissue volume between the two groups (P<0.05); analysis of bone biopsies showed statistically significant differences in new bone percentage between the two groups (P<0.05); and the difference in ISQ between the two groups was statistically significant (P<0.05) at 3 months after the implant surgeries. Conclusion: The combined application of rhBMP-2 and DBBM in ESFE is more favorable to the formation of new bone than DBBM alone, which can create more favorable bone conditions for subsequent implant surgery.

Key words: external sinus floor elevation, recombinant human bone morphogenetic protein-2, deproteinized bovine bone mineral, oral implantology

汤正婷, 杨德钊, 李光成, 孟凡文. 重组人骨形态发生蛋白-2与去蛋白牛骨基质在上颌窦底外提升中联合应用研究[J]. 口腔医学研究, 2026, 42(3): 213-218.

TANG Zhengting, YANG Dezhao, LI Guangcheng, MENG Fanwen. Study on rhBMP-2 Combined with DBBM Used in External Sinus Floor Elevation[J]. Journal of Oral Science Research, 2026, 42(3): 213-218.

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