口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (10): 974-977.

• 基础研究论著 • 上一篇    下一篇

牙科用锆基非晶合金的细胞毒性及血液相容性研究

曹尤雅1,孙宇*,程翔,刘桂英,马越,孙英博,王芳   

  1. 1. 哈尔滨医科大学附属口腔医院口腔修复科 黑龙江 哈尔滨 150001;
    2. 哈尔滨工业大学 黑龙江 哈尔滨 150001
  • 收稿日期:2015-03-27 出版日期:2015-10-28 发布日期:2016-05-04
  • 通讯作者: 孙宇,E-mail:sunyu20060212@126.com
  • 作者简介:曹尤雅(1989~ ),女,黑龙江人,硕士在读,主要从事口腔修复材料的生物安全性研究。
  • 基金资助:
    黑龙江省教育厅科研课题(编号:12531322)

Cell Toxicity and Blood Compatibility of Zr Based Amorphous Alloy for Dentistry

CAO You-ya1, SUN Yu, CHENG Xiang, LIU Gui-ying, MA Yue, SUN Ying-bo, WANG Fang 1   

  1. Stomatology Hospital of Harbin Medical University, Harbin 150001, China;
    2. Harbin Institute of Technology, Harbin 150001, China
  • Received:2015-03-27 Online:2015-10-28 Published:2016-05-04

PDF (PC)

310

被引次数

1

摘要： 目的:测定高强度、高弹性模量的新型口腔种植用锆基非晶合金的细胞毒性及血液相容性。方法:通过锆基非晶合金与新鲜人血接触进行血液相容性实验并采用MTT法研究锆基非晶合金的细胞毒性。结果:细胞毒性试验显示本研究制备的锆基非晶合金的细胞毒性反应分级为0级,无细胞毒性;血液相容性试验结果锆基非晶合金溶血率低,动态凝血时间较纯钛及Ti6Al4V延长,以PT、APTT为指标的抗凝血性能与纯钛、Ti6Al4V相当,血小板粘附试验中Zr-Cu-Al-Ag较少出现血小板黏附,团聚及伪足伸出现象。结论:Zr-Cu-Al-Ag拥有良好的细胞相容性、血液相容性,可以初步满足其作为口腔种植材料的基本应用要求。

关键词: 锆基非晶合金, 血液相容性, 细胞毒性

Abstract: Objective: To evaluate the cell toxicity and hemo-compatibility of the Zr based amorphous alloy with high strength and modulus of elasticity for dentistry. Methods: Zr based amorphous alloy was performed the hemolysis test by contacting with fresh human blood. MTT method was applied to study the cytotoxicity of this alloy. Results: The level of cell toxicity of Zr based amorphous alloy was 0, which meant no cell toxicity. The Zr based amorphous alloy had low hemolytic rate, long dynamic clotting time, similar anticoagulant capability to pure titanium and Ti6Al4V. The platelet adhesion test implied that Zr-Cu-Al-Ag alloy had seldom pseudopodium phenomenon. Conclusion: Zr-Cu-Al-Ag alloy has adequate cytocompatibilty and blood compatibility, which might meet the basic need of oral implantation.

Key words: Zr based amorphous alloy, Blood compatibility, Cytotoxicity

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