单侧前牙反牙合对大鼠咬肌压痛阈值影响的长程观察

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (3): 217-219.

单侧前牙反牙合对大鼠咬肌压痛阈值影响的长程观察

廖立凡, 井磊^△, 张虹云, 杨鸿旭, 万向洪, 刘晓东, 王美青^*

第四军医大学口腔医学院解剖生理教研室陕西西安 710032

收稿日期:2014-11-25 出版日期:2015-03-28 发布日期:2016-04-29
通讯作者: 王美青,电话:(029) 84776143
作者简介:廖立凡(1983~ ),女,河南人,博士在读,医师,主要研究方向为牙合学与颞下颌关节紊乱病。井磊(1984~ ),男,陕西人,博士在读,医师,主要研究方向为牙合学与颞下颌关节紊乱病。
基金资助:
国家自然科学基金资助项目(编号:81271169 )

Long-term Effects of Unilateral Anterior Crossbite on the Pressure Pain Threshold of Rats Masseters.

LIAO Li-fan, JIN Lei, ZHANG Hong-yun, et al.

Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, Xi’an 710032

Received:2014-11-25 Online:2015-03-28 Published:2016-04-29

摘要/Abstract

摘要： 目的:探讨单侧前牙反牙合所致大鼠咬肌压痛阈值随时间变化特点。方法:以金属套筒建立大鼠单侧前牙反牙合,分别在造模后4、12、16、20周处死,其中20周组造模后第1、3、5、7天,第2、4、8、12、16、20周时,4、12、16周组在造模后第1、3、5、7天以及处死前分别检测反牙合侧咬肌区压痛阈值。结果:单侧前牙反牙合可诱发大鼠咬肌疼痛阈值的下降(P<0.05)。从实验后第1天便有明显下降,于第3天达到峰值,第5、7天逐渐上升,第2周以后直至20周取材时与同龄对照相比,不再有明显差异。20周组在4、12、16周时间点的检测结果,与取材时间点的检测结果相比,未见明显差异。雌雄组之间未见明显差异。结论:单侧前牙反牙合可导致大鼠同侧咬肌出现短期、可恢复的疼痛阈值下降。

关键词: 颞下颌关节, 咬肌, 压痛阈值

Abstract: Objective: To explore the pressure pain threshold(PPT) changes of masseters induced by the unilateral anterior crossbite (UAC) prosthesison rats. Methods: UAC model was set up with metal tubes on rats which were sacrificed at weeks 4,12,16,20. And then the PPTof ipsilateral masseters of the 20w groups were observed at day1, 3, 5, 7 and week 2,4,8,12,16,20 after UAC, while the PPT of ipsilateral masseters of the 4w,12w and 16w groups were observed at day1, 3, 5, 7 and the day they were sacrificed. Resules: The UAC leaded to decreased PPT (P<0.05). And the decreased PPT was significant from the day1, and peaked at day3 after UAC. Then the value of PPT increased gradually at day5 and day7, and there was no significant difference between the control group and the UAC group from week 2 to weeks 20. The PPTs of the 20w group at 4 weeks,12 weeks and 16weeks had no significant differences with the 4w group, the 12w group and the 16w group respectively. And at the same time, there was no significant difference of PPTs between the female and male rats significantly. Conclusion: The unilateral anterior crossbite can induce the acute, short-term and restorable decrease of PPT of ipsilaterl masseters of rats.

Key words: Temporomandibular joint , Masseter , Pressure pain threshold

中图分类号:

R782.6

廖立凡, 井磊, 张虹云, 杨鸿旭, 万向洪, 刘晓东, 王美青. 单侧前牙反牙合对大鼠咬肌压痛阈值影响的长程观察[J]. 口腔医学研究, 2015, 31(3): 217-219.

LIAO Li-fan, JIN Lei, ZHANG Hong-yun, et al.. Long-term Effects of Unilateral Anterior Crossbite on the Pressure Pain Threshold of Rats Masseters.[J]. Journal of Oral Science Research, 2015, 31(3): 217-219.

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