小分子RNA在干细胞成骨及成软骨分化中的作用

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (8): 845-.

• • 上一篇

小分子RNA在干细胞成骨及成软骨分化中的作用

蒋少云^*,薛栋,邓嘉胤

天津医科大学口腔医院牙周科天津 300070

收稿日期:2014-03-28 出版日期:2015-08-28 发布日期:2016-05-04
通讯作者: 蒋少云,E-mail:jiangshaoyun@tmu.edu.cn
作者简介:蒋少云(1972~ ),女,湖南新宁,副教授,博士,牙周炎发病机制及牙周组织工程学。
基金资助:
国家自然科学基金(青年科学基金项目:81100758/H1405);天津市高等学校科研基金项目(编号:2010134)

Effects of MicroRNA on the Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells

JIANG Shao-yun, XUE Dong, DENG Jia-yin

Department of Periodontics, Stomatologic Hospital, Tianjin Medical University, Tianjin 300070

Received:2014-03-28 Online:2015-08-28 Published:2016-05-04

摘要/Abstract

摘要： 小分子RNA(microRNA,miRNA)是内源性非编码单链小分子RNA,具有重要的生物学功能,对基因进行转录后调控,从而参与调节细胞增殖和分化,影响个体生长发育和疾病的发生过程。近年来越来越多的研究显示miRNA对间充质干细胞的成骨和成软骨向分化起着重要的调节作用,本文就miRNA在这方面的研究进展做一综述。

关键词: 小分子RNA, 成骨, 成软骨, 分化

Abstract: MicroRNA (miRNA) is endogenous, non-coding RNA with important biological function, and regulates cell proliferation and differentiation in the post-transcriptional processes, which affects the development of body and diseases.More and more recent researches have shown that miRNA regulated osteogenic and chondrogenic differentiation of mesenchymal stem cells, which is reviewed in this article.

Key words: MicroRNA, Osteogenic, Chondrogenic, Differentiation

中图分类号:

R782.1

蒋少云,薛栋,邓嘉胤. 小分子RNA在干细胞成骨及成软骨分化中的作用[J]. 口腔医学研究, 2015, 31(8): 845-.

JIANG Shao-yun, XUE Dong, DENG Jia-yin. Effects of MicroRNA on the Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells[J]. Journal of Oral Science Research, 2015, 31(8): 845-.

参考文献

[1] Bartel DP. MicroRNAs: genomics, biogenesis, mechanism and function [J]. Cell, 2004, 116(2)∶281-297
[2] Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cell [J]. Science, 1999, 284(5411)∶143-147
[3] Yi R, Qin Y, Macara IG, et al. Exportin-5 mediates the nuclear export of pre-microRNA and short hairpin RNAs [J]. Genes Dev, 2003, 17(24)∶3011-3016
[4] Ruby JG, Jan CH, Bartel DP. Intronic microRNA precursors that bypass Drosha processing [J]. Nature, 2007, 448(7149)∶83-86
[5] Friedman RC, Farh KKH, Burge CB, et al. Most mammalian mRNA are conserved targets of microRNAs [J]. Genome Res, 2009, 19(1)∶92-105
[6] Huang Y, Shen XJ, Zou Q, et al. Biological functions of microRNAs: a review [J]. J Physicol Biochem, 2011, 67(1)∶129-139
[7] Oskowitz AZ, Lu J, Penfornis P, et al. Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression [J]. Proc Natl Acad Sci U S A, 2008, 105(47)∶18372-18377
[8] Harfe BD, McManus MT, Mansfield JH, et al. The RNaseⅢ enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb [J]. Proc Natl Acad Sci U S A, 2005, 102(31)∶10898-10903
[9] Eskildsen T, Taipaleenmaki H, Stenvang J, et al. MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo [J]. Proc Natl Acad Sci U S A, 2011, 108(15)∶6139-6144
[10] Itoch T, Ando M, Tsukamasa Y, et al. Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370 [J]. FEBS Letters, 2012, 586(12)∶1693-1701
[11] Huang J, Zhao L, Xing L, et al. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation [J]. Stem Cells, 2010, 28(2)∶357-364
[12] Inose H, Ochi H, Kimura A, et al. A microRNA regulatory mechanism of osteoblast differentiation [J]. Proc Natl Acad Sci U S A, 2009, 106(49)∶20794-20799
[13] Tomé M, López-Romero P, Albo C, et al. miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cell [J]. Cell death differ, 2011, 18(6)∶985-995
[14] Kapinas K, Kessler C, Ricks T, et al. miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop [J]. J Biol Chem, 2010, 285(33)∶25221-25231
[15] Zhang J, Tu Q, Bonewald LF, et al. Effects of miR-335-5p in modulating osteogenic differentiation by specifically down-regulating Wnt antagonist DKK1 [J]. J Bone Miner Res, 2011, 26(8)∶1953-1963
[16] Hu R, Liu W, Li H, et al. A Runx2/ miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation [J]. J Biol Chem, 2011, 286(14)∶12328-12339
[17] Li H, Li T, Wang S, et al. miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells [J]. Endocrine, 2014, 45(2)∶302-310
[18] Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis [J]. Genes Dev, 2010, 24(11)∶1173-1185
[19] Miyaki S, Nakasa T, Otsuki S, et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses [J]. Arthritis Rheum, 2009, 60(9)∶2723-2730
[20] Martinez-Sanchez A, Dudek KA, Murphy CL. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145) [J]. J Biol Chem, 2012, 287(2)∶916-924
[21] Wu T, Xie M, Wang X, et al. miR-155 modulates TNF-α-inhibited osteogenic differentiation by targeting SOCS1 expression [J]. Bone, 2012, 51(3)∶498-505

小分子RNA在干细胞成骨及成软骨分化中的作用

Effects of MicroRNA on the Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells

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