口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (4): 412-415.DOI: 10.13701/j.cnki.kqyxyj.2016.04.024

• 临床研究论著 • 上一篇    下一篇

不同时期口腔种植修复患者血清CRP与尿脱氧吡啶啉含量变化与相关性

张岩1*,杨丽丽1,张志勇2,徐杰1   

  1. 1. .沧州市人民医院口腔科 河北 沧州 061000;
    2. 河北医科大学第二医院 河北 石家庄 050000
  • 收稿日期:2015-09-01 出版日期:2016-04-28 发布日期:2016-04-28
  • 通讯作者: 张岩,电话:0317-3521095
  • 作者简介:张岩(1982~ ),男,河北人,主治医师,硕士,主要从事口腔颌面外科及口腔种植临床及基础的研究工作。

Study on Changes and Correlation of Serum CRP and Urinary DPd Content in Patients at Different Stages of Oral Implant Repair.

ZHANG Yan1*, YANG Li-li1, ZHANG Zhi-yong2, XU Jie1.   

  1. 1. Department of Stomatology, Cangzhou People Hospital, Cangzhou 061000, China;
    2. Second Hospital of Hebei Medical University, Shijiazhuang 05000, China
  • Received:2015-09-01 Online:2016-04-28 Published:2016-04-28

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摘要： 目的:测定不同时期(术前1 d、术后1月、术后半年)口腔种植修复患者血清CRP与尿脱氧吡啶啉含量,探讨其含量变化规律及上述两的检测指标的相关性。方法:收集接受单颗人工种植牙修复的患者86例,并符合本实验纳入标准。将上述患者分别于术前1 d,术后1个月、术后6个月进行血清CRP及尿DPd的检测,所得数据设定为A1组、A2组、A3组。结果:术后1月血清CRP较术前1 d所测得的血清CRP有明显升高,术后半年所测得血清CRP则呈现回落趋势(P<0.05),3组总体均数之间存在统计学差异,组间比较,术后1月血清CRP数据与另外两组存在明显统计学差异(P<0.05),术后半年血清CRP数据虽高于术前1 d组数据,但两者无统计学意义(P>0.05)。对于术前1 d、术后1月和术后半年尿DPd数据进行统计学分析,后两者均高于术前1 d尿DPd,其中以术后1月组数据最高(P<0.05),3组总体均数之间存在统计学差异,组间比较,术日术前组数据与术后1月和术后半年组均存在显著差异(P<0.05),术后两组尿DPd数据不存在统计学差异(P>0.05)。实验组不同时期检测到的血清CRP和尿DPd数据经统计学分析呈正相关。结论:在口腔种植修复过程中,牙槽骨吸收改建的活跃期,血清CRP与尿DPd含量会出现升高,且两者之间存在明显的相关性。血清CRP与尿DPd可以初步探讨作为反映牙槽骨吸收改建的检测指标。

关键词: 口腔种植修复, C-反应蛋白, 脱氧吡啶啉, 含量变化, 相关性

Abstract: Objective: To study the changes and correlation of serum CRP and urine DPd content for different periods (1 day before operation, 1 month after operation, and six months after operation). Methods: Totally 86 cases of implant restoration in patients between 25-45 years old, without periodontitis and chronic disease, were enrolled in the study. The serum CRP and urine DPd of the patients 1 day before operation (A1 group), 1 month after the operation (A2 group) and half year after the operation (A3 group) were collected. Results: Compared with A1 group, serum CRP in A2 group was significantly increased while in A3 group showed a downward trend (P<0.05). The serum CRP level in A2 group was significantly higher than the other two groups (P<0.05). Though the serum CRP level in A3 group was higher than A1 group, there was no statistical significance (P>0.05). As compared the levels of urinary DPd, A1 group was significant lower than A2 and A3 groups and the data of A2 group was the highest (P<0.05). There was statistical difference among three groups of the overall mean. Serum CRP was positively correlation with urinary DPd by statistical analysis (P<0.001). Conclusion: Serum CRP and urine DPd content would increase in the active stage of alveolar bone remodeling during the implant restoration process. There was a significant correlation between two indices. Serum CRP and urinary DPd could be regarded as an index reflecting alveolar bone resorption and remodeling

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