颌骨骨髓炎中IL-17、IL-6和IL-1β的表达

doi:10.13701/j.cnki.kqyxyj.2017.10.016

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (10): 1082-1085.DOI: 10.13701/j.cnki.kqyxyj.2017.10.016

颌骨骨髓炎中IL-17、IL-6和IL-1β的表达

王俊英，撒国良，刘志康，何三纲^*

武汉大学口腔医学院口腔生物医学教育部重点实验室湖北武汉 430079

收稿日期:2017-04-27 出版日期:2017-10-20 发布日期:2017-10-24
通讯作者: 何三纲,E-mail:sangang@whu.edu.com
作者简介:王俊英(1990~ ),女,湖北人,硕士在读,主要从事口腔颌面外科学研究。
基金资助:
国家自然科学基金资助项目(编号:81371126)

Expressions of IL-17, IL-1β, and IL-6 in Osteomyelitis of Jaw

WANG Jun-ying, SA Guo-liang, LIU Zhi-kang, HE San-gang^*

Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University. Wuhan 430079, China.

Received:2017-04-27 Online:2017-10-20 Published:2017-10-24

摘要/Abstract

摘要： 目的:对化脓性及放射性下颌骨骨髓炎患者病变骨组织进行免疫组化染色,检测IL-17、IL-6和IL-1β在2种不同病因的颌骨骨髓炎中的表达情况。方法:取化脓性及放射性颌骨骨髓炎患者病变骨组织做样本,HE染色观察局部骨组织的结构,并用免疫组织化学方法检测局部组织中IL-17、IL-6和IL-1β的表达情况,与健康骨组织作对比。结果:IL-17、IL-6在化脓性颌骨骨髓炎中表达水平明显升高,而放射性颌骨骨髓炎局部组织中IL-17、IL-6的表达与正常组织无显著差异。化脓性与放射性颌骨骨髓炎局部骨组织中IL-1β的表达水平与正常骨组织相比有显著差异,而在2种骨髓炎中的表达差异不明显。结论:IL-17、IL-6在化脓性颌骨骨髓炎的成骨与破骨失衡中可能有更重要的作用,而与放射性颌骨骨髓炎关系不密切。IL-1β是颌骨骨髓炎发生的重要因素。

关键词: 化脓性颌骨骨髓炎, 放射性颌骨骨髓炎, 白细胞介素-17, 白细胞介素-6, 白细胞介素-1β

Abstract: Objective: To investigate the expression of IL-17, IL-6, and IL-1β in osteomyelitis of different etiology in patients with pyogenic and radioactive osteomyelitis of mandible. Methods: Lesion bone was obtained from patients who were diagnosed as suppurative or radioactive osteomyelitis of mandible. Hematoxylin eosin staining was used to observe the structure of local bone, and the expression levels of IL-17, IL-6, and IL-1β in local tissues were detected by immunohistochemistry. Results: IL-17 and IL-6 was significantly increased in pyogenic osteomyelitis. However, the expression of IL-17 and IL-6 was insignificant different between radiation osteomyelitis and normal bone. The expression levels of IL-1β in the local of pyogenic and radioactive osteomyelitis were both increased compared to the normal bone tissues. Conclusion: IL-17 and IL-6 may play a more important role in imbalance between bone formation and bone resorption in the suppurative osteomyelitis, whereas, it has marginal effect on the radioactive osteomyelitis. IL-1β may involve in the occurrence of osteomyelitis of jaws.

Key words: Suppurative osteomyelitis of jaw, Radioactive osteomyelitis of jaw, IL-17, IL-6, IL-1β

中图分类号:

R782.2

王俊英，撒国良，刘志康，何三纲. 颌骨骨髓炎中IL-17、IL-6和IL-1β的表达[J]. 口腔医学研究, 2017, 33(10): 1082-1085.

WANG Jun-ying, SA Guo-liang, LIU Zhi-kang, HE San-gang. Expressions of IL-17, IL-1β, and IL-6 in Osteomyelitis of Jaw[J]. Journal of Oral Science Research, 2017, 33(10): 1082-1085.

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颌骨骨髓炎中IL-17、IL-6和IL-1β的表达

Expressions of IL-17, IL-1β, and IL-6 in Osteomyelitis of Jaw

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