颌面部溶骨症的临床研究

doi:10.13701/j.cnki.kqyxyj.2017.12.018

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (12): 1310-1313.DOI: 10.13701/j.cnki.kqyxyj.2017.12.018

颌面部溶骨症的临床研究

曲禄瑶,蔡协艺^*

上海交通大学医学院附属第九人民医院口腔外科,上海市口腔医学重点实验室,国家口腔疾病临床研究中心上海 200011

收稿日期:2017-07-17 出版日期:2017-12-20 发布日期:2018-01-03
通讯作者: 蔡协艺,E-mail:caixieyi27@126.com
作者简介:曲禄瑶(1993~ ),女,辽宁大连人,硕士在读,主要从事口腔外科学研究。

Clinical Study of Gorham Disease in Maxillofacial Region.

QU Lu-yao, CAI Xie-yi^*.

Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine;Shanghai Key Laboratory of Stomatology;National Clinical Research Center of Stomatology. Shanghai 200011, China.

Received:2017-07-17 Online:2017-12-20 Published:2018-01-03

摘要/Abstract

摘要： 目的: 回顾分析于本院就诊的颌面部溶骨症患者的临床和影像学表现,以及应用双磷酸盐药物的治疗效果,从而增进对颌面部溶骨症的了解。方法: 回顾2010年1月~2016年5月就诊于上海交通大学医学院附属第九人民医院口腔外科被诊断为颌面部溶骨症的患者,分析其发病年龄、发生部位、临床表现、影像学检查、实验室检查、治疗手段及治疗效果。结果: 共收集到4例患者,其中男女各2例。平均就诊年龄40岁,发生于下颌骨2例,下颌骨颞骨2例。4例均行CT检查,表现为病变部位骨质吸收,软组织萎缩。4例患者口服阿仑膦酸钠片治疗。其中4例服用后溶骨无明显加剧。结论: 颌面部的溶骨症可发生于颌面诸骨,可单发,也可多发。患者多为中青年。诊断主要依靠影像学手段,实验室检查无特殊性。阿仑膦酸钠片可作为一种治疗手段,疗效较为稳定。

关键词: 溶骨症, 下颌骨, 影像学, 阿仑膦酸钠

Abstract: Objective: To investigate the clinical features, imaging examination and treatment of the patients with Gorham disease in maxillofacial region. Methods: The medical records of the patients with Gorham Disease who were referred to Shanghai Ninth People's Hospital from January 2010 to 2016 May were reviewed. Their ages, lesion location, imaging results, laboratory examination results, and treatment and therapeutic effects were analyzed. Results: A total of 4 cases were included (2 male and 2 female). The average onset age was 40 year olds. Gorham disease attacked the mandible in 2 cases, and mandible and temporal bone in other 2 cases. All cases were examined by CT, which showed bone resorption and atrophy of soft tissue. Four patients were given alendronate to treat Gorham disease. All of them had not significant bone resorption after the treatment. Conclusion: Gorham disease can affect any maxillofacial bone, whether single bone or multiple bones. The patients are mostly young and middle-aged. The diagnosis mainly depends on the imaging methods and the laboratory examination has not special meaning. Alendronate can be used and the effect is certain.

Key words: Gorham disease, Mandibular, Imaging examination, Alendronate

中图分类号:

R782.2

曲禄瑶,蔡协艺. 颌面部溶骨症的临床研究[J]. 口腔医学研究, 2017, 33(12): 1310-1313.

QU Lu-yao, CAI Xie-yi.. Clinical Study of Gorham Disease in Maxillofacial Region.[J]. Journal of Oral Science Research, 2017, 33(12): 1310-1313.

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颌面部溶骨症的临床研究

Clinical Study of Gorham Disease in Maxillofacial Region.

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