自体牙本质基质在牙槽嵴保存术中的研究进展

doi:10.13701/j.cnki.kqyxyj.2026.07.003

摘要/Abstract

摘要： 自体牙本质基质(autogenous dentin matrix, ADM)作为一种来源于自体的天然骨替代材料,因其良好的生物相容性与成骨潜力,在口腔种植修复领域尤其在牙槽嵴保存术(alveolar ridge preservation, ARP)中受到广泛关注。ADM保留了天然牙本质的矿化结构和生物活性,兼具骨传导性与骨诱导性,可有效促进新骨形成并维持拔牙后骨量。本文综述了ADM的材料特性、成骨机制及在ARP中的应用现状,通过比较其与传统骨移植材料的优势,探讨了当前存在的制备标准化及长期疗效验证等问题。通过工艺优化与开展更多临床研究,未来有望进一步拓展ADM在口腔种植领域的应用前景。

关键词: 自体牙本质基质, 牙槽嵴保存术, 骨组织再生, 口腔种植修复, 骨移植材料

Abstract: Autogenous dentin matrix (ADM), derived from extracted teeth of patients, has emerged as a novel natural bone substitute with excellent biocompatibility and osteogenic potential. In recent years, ADM has attracted increasing attention in the field of oral implantology, particularly for alveolar ridge preservation (ARP). ADM retains the mineralized structure and biological activity of natural dentin, providing osteoconductive and osteoinductive properties that effectively promote new bone formation and maintain alveolar bone volume after tooth extraction. This review summarizes the material characteristics and osteogenic mechanisms of ADM, outlines its current clinical applications in ARP, and compares its performance with conventional bone graft materials. Furthermore, it discusses existing challenges such as the lack of standardized preparation protocols and limited long-term clinical evidence. With ongoing optimization of processing techniques and advances in clinical research, ADM is expected to achieve broader clinical applications in oral implantology and bone regeneration.

Key words: autogenous dentin matrix, alveolar ridge preservation, bone tissue regeneration, oral implant restoration, bone graft materials

夏洁, 杨帆. 自体牙本质基质在牙槽嵴保存术中的研究进展[J]. 口腔医学研究, 2026, 42(7): 564-568.

XIA Jie, YANG Fan. Advances on Autogenous Dentin Matrix for Alveolar Ridge Preservation[J]. Journal of Oral Science Research, 2026, 42(7): 564-568.

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