以牙龈病变为首发症状的非霍奇金淋巴瘤

doi:10.13701/j.cnki.kqyxyj.2017.08.018

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (8): 874-876.DOI: 10.13701/j.cnki.kqyxyj.2017.08.018

以牙龈病变为首发症状的非霍奇金淋巴瘤

孙维克¹, 巩雪梅¹, 董大群¹, 周卉卉^2*

1. 滨州医学院口腔医学院山东烟台 264003;
2. 青岛医学院附属烟台毓璜顶医院病理科山东烟台 264003

收稿日期:2017-05-08 出版日期:2017-08-20 发布日期:2017-08-28
通讯作者: 周卉卉,E-mail:yhdyypathology@163.com
作者简介:孙维克(1979~ ),女,山东威海人,硕士,讲师,主要从事口腔组织病理学、口腔医学教育研究。
基金资助:
山东省医药卫生科技发展计划项目(编号:2013WS0039)

Gingival Lesions Presenting as the First Symptom: Clinicopathologic Characteristics of Gingival non-Hodgkin’s Lymphoma.

SUN Wei-ke¹, GONG Xue-mei¹, DONG Da-qun¹, ZHOU Hui-hui^2*.

1. School of Stomatology, Binzhou Medical College. Yantai 264003, China;
2. Department of Pathology, Yuhuangding Hospital affiliated to Qingdao Medical College. Yantai, 264003, China.

Received:2017-05-08 Online:2017-08-20 Published:2017-08-28

摘要/Abstract

摘要： 目的:探讨以牙龈病变为首发症状的淋巴瘤临床病理分析及预后转归情况。方法:回顾2011~2017年4例以牙龈病变为首发症状的非霍奇金淋巴瘤,结合国内外关于牙龈的淋巴瘤的相关文献报道,分析其临床特点及组织病理学类型,并随访其治疗情况及预后。结果:4例牙龈淋巴瘤患者男1例,女3例,平均年龄59岁。发生部位上颌牙龈3例,下颌牙龈1例。其中弥漫大B细胞淋巴瘤2例,均为生发中心起源,间变大细胞淋巴瘤1例及浆细胞瘤1例。结论:牙龈淋巴瘤非常罕见,几乎均为非霍奇金淋巴瘤,以弥漫大B细胞淋巴瘤为主,牙龈淋巴瘤的确诊依赖病理活检,免疫标记对明确诊断、分型及鉴别诊断具有一定的诊断价值。

关键词: 牙龈, 淋巴瘤, 临床病理, 免疫组化

Abstract: Objective: To investigate the clinicopathologic characteristics and prognosis of gingival non-Hodgkin’s lympahoma (NHL). Methods: Four cases of NHL whose first symptoms were gingival lesions were analyzed. The clinicopathologic and immunohistochemical characteristics were retrospectively studied and the relevant literatures were reviewed. Results: The median age of 4 patients was 59 (43-69). They were 1 male and 3 females. Three cases occurred in maxillary gingival and one case occurred in mandibular gingival. Two cases were diffused large B cell lymphoma (DLBCL), 1 case was anaplastic large cell lymphoma, ALK-negative (ALCL, ALK-negative), and the last one was plasma cell neoplasms. Conclusion: Lymphoma of gingival is very rare and almost NHL, predominated by DLBCL. The diagnosis of gingival lymphoma depends on pathological biopsy. Immunohistochemistry is conducive to diagnosis, typing, and differential diagnosis.

Key words: Gingival lymphoma , Clinical pathological, Immunohistochemistry

中图分类号:

R739.8

孙维克, 巩雪梅, 董大群, 周卉卉. 以牙龈病变为首发症状的非霍奇金淋巴瘤[J]. 口腔医学研究, 2017, 33(8): 874-876.

SUN Wei-ke, GONG Xue-mei, DONG Da-qun, ZHOU Hui-hui.. Gingival Lesions Presenting as the First Symptom: Clinicopathologic Characteristics of Gingival non-Hodgkin’s Lymphoma.[J]. Journal of Oral Science Research, 2017, 33(8): 874-876.

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以牙龈病变为首发症状的非霍奇金淋巴瘤

Gingival Lesions Presenting as the First Symptom: Clinicopathologic Characteristics of Gingival non-Hodgkin’s Lymphoma.

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