3D打印个性化钛网重建牙槽嵴骨缺损的实验研究

doi:10.13701/j.cnki.kqyxyj.2019.01.019

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (1): 80-83.DOI: 10.13701/j.cnki.kqyxyj.2019.01.019

3D打印个性化钛网重建牙槽嵴骨缺损的实验研究

王超, 夏荣^*, 刘芮, 肖楠楠

安徽医科大学第二附属医院口腔科安徽合肥 230601

收稿日期:2018-07-16 出版日期:2019-01-18 发布日期:2019-01-28
通讯作者: 夏荣,E-mail:xiarongqh@aliyun.com
作者简介:王超(1989~ ),男,安徽宣城人,医师,硕士在读,主要从事种植体表面改性研究。

Experimental Study on Reconstruction of Alveolar Ridge Defects with Personalized Titanium Mesh Based on 3D Printing Technology

WANG Chao, XIA Rong^*, LIU Rui, XIAO Nan-nan

Department of Dental Implantation, Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China

Received:2018-07-16 Online:2019-01-18 Published:2019-01-28

摘要/Abstract

摘要： 目的:通过体内动物实验,研究一种新型个性化钛网在牙槽嵴骨缺损美学形态重建上的优势。方法:实验选取6只比格犬,根据个性化钛网三维建模方法,虚拟切除下颌双侧前磨牙及部分牙槽骨,通过软件重建并设计出个性化钛网,并对打印成品进行理化性能检测。分别拔除比格犬双侧下颌第二、三前磨牙,设计双侧下颌骨骨缺损模型,分别进行骨粉＋常规钛网(CTM组,conventional titanium mesh)、骨粉＋个性化钛网(PTM组,personalized titanium mesh) 的重建修复,术中记录两组手术时间、膜龈暴露及术后感染情况。术后4个月,取出钛网,记录牙槽嵴高度差异,同时,通过Micro-CT扫描比较两种骨重建方法在牙槽嵴骨量和形态上的差异。结果:新型个性化钛网减少了GBR手术持续时间大约30 min;术后感染,CTM组中出现2例感染,而PTM组只有1例感染,两组的差异是16.6%;术后4月去除钛网,PTM组骨缺损可见牙槽嵴形态结构,2组间牙槽嵴高度存在统计学差异(P<0.05),骨重建效果PTM组>CTM组;Micro-CT扫描结果,发现两组钛网术后骨再生程度和形态上相差较明显,两组间比较具有统计学差异(P＜0.05)。结论:新型个性化钛网具有独特的牙槽嵴形态,具有良好的理化性能。体内实验证明新型个性化钛网具有良好的生物相容性,有利于后期骨缺损牙槽嵴的美学形态重建。

关键词: 3D打印, 钛网, 骨缺损, 引导骨再生

Abstract: Objective: To study the effect of a new type of personalized titanium mesh in the aesthetic reconstruction of alveolar ridge defects in vivo. Methods: Six beagles were selected. According to three-dimensional modeling method, the mandible premolars and part of alveolar bone were virtually resented. Corresponding personalized titanium mesh was rebuilt and designed through software, and the finished products were checked the physical and chemical properties. Bilateral mandibular second and third premolars were extracted respectively. Bilateral mandibular bone defects were designed and reconstructed with bone powder + conventional titanium mesh (CTM group) and bone powder + individualized titanium mesh (PTM group). The operation time, membrane gingival exposure, and postoperative infection were recorded. Four months after surgery, titanium mesh was taken out, and the difference in alveolar ridge height was recorded. Meanwhile, the difference of volume and morphology of alveolar ridge between two methods was compared by micro-CT scanning. Results: The new personalized titanium mesh reduced the duration of GBR surgery by about 30 minutes. There were 2 cases of infection in the CTM group, while only 1 case in the PTM group, which showed a difference of 16.6% between two groups. Four months after surgery, the bone defect in PTM group showed the morphological structure of alveolar ridge. There was a statistically significant difference in alveolar ridge height between two groups (P<0.05). Micro-CT scanning confirmed the results. Conclusion: The new type of personalized titanium mesh has unique alveolar ridge morphology and good physical and chemical properties.

Key words: 3D printing, Titanium mesh, Bone defect, Guided bone regeneration

王超, 夏荣, 刘芮, 肖楠楠. 3D打印个性化钛网重建牙槽嵴骨缺损的实验研究[J]. 口腔医学研究, 2019, 35(1): 80-83.

WANG Chao, XIA Rong, LIU Rui, XIAO Nan-nan. Experimental Study on Reconstruction of Alveolar Ridge Defects with Personalized Titanium Mesh Based on 3D Printing Technology[J]. Journal of Oral Science Research, 2019, 35(1): 80-83.

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3D打印个性化钛网重建牙槽嵴骨缺损的实验研究

Experimental Study on Reconstruction of Alveolar Ridge Defects with Personalized Titanium Mesh Based on 3D Printing Technology

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