纳米载药系统靶向肿瘤相关巨噬细胞用于肿瘤治疗的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.06.001

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (6): 511-516.DOI: 10.13701/j.cnki.kqyxyj.2019.06.001

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纳米载药系统靶向肿瘤相关巨噬细胞用于肿瘤治疗的研究进展

孙宏晨^*,李杏

中国医科大学口腔医学院辽宁沈阳 110000

收稿日期:2019-04-30 出版日期:2019-06-28 发布日期:2019-06-27
作者简介:孙宏晨中国医科大学口腔医院院长,教授,博士生导师,长白山学者特聘教授,兼任中华口腔医学会口腔病理专业委员会候任主任委员。曾以国家公派访问学者身份和国家公派高级研究学者身份赴东京医科齿科大学和美国密歇根大学从事合作研究。研究方向为功能性纳米材料在骨再生和口腔癌诊疗中的应用研究。主持国家重点研发专项1项, 国家自然科学基金项目7项, 其中1项为重点项目、1项为重点国际合作项目。发表国际期刊论文80余篇。

Advances in Nanomedicine Strategies to Target Tumor-associated Macrophage

SUN Hong-chen, LI Xing

School of Stomatology, China Medical University, Shenyang 110000, China.

Received:2019-04-30 Online:2019-06-28 Published:2019-06-27

摘要/Abstract

摘要： 肿瘤相关巨噬细胞(tumor associated macrophage,TAM)是肿瘤微环境内一类重要的免疫细胞,对肿瘤的发生、发展均具有重要影响。以TAM为靶点的肿瘤免疫治疗是肿瘤治疗的前沿和研究热点。纳米载药系统由于优良的理化性质为靶向调控TAM提供了新的思路和方向。本文阐述了以TAM为靶点的肿瘤治疗及纳米材料调控TAM杀伤肿瘤细胞的新策略。

关键词: 肿瘤相关巨噬细胞, 靶向治疗, 纳米载药系统

Abstract: Tumor associated macrophage (TAM), one of the most important immune cells in tumor microenvironment, plays an important part in the occurrence and development of tumor. TAM-targeted immunotherapy is the frontier and hotspot of tumor therapy. Due to its excellent physical and chemical properties, nano-drug delivery system provides a new idea and direction for targeted regulation of TAM. In this paper, the current situation of targeted regulation of TAM by nanomaterials to kill tumor cells is reviewed.

Key words: Tumor associated macrophage, Target therapy, Nanomaterials

孙宏晨,李杏. 纳米载药系统靶向肿瘤相关巨噬细胞用于肿瘤治疗的研究进展[J]. 口腔医学研究, 2019, 35(6): 511-516.

SUN Hong-chen, LI Xing. Advances in Nanomedicine Strategies to Target Tumor-associated Macrophage[J]. Journal of Oral Science Research, 2019, 35(6): 511-516.

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纳米载药系统靶向肿瘤相关巨噬细胞用于肿瘤治疗的研究进展

Advances in Nanomedicine Strategies to Target Tumor-associated Macrophage

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